KEGG   Homo sapiens (human): 412
Entry
412               CDS       T01001                                 
Symbol
STS, ARSC, ARSC1, ASC, ES, SSDD, XLI
Name
(RefSeq) steryl-sulfatase isoform 1 precursor
  KO
K01131  steryl-sulfatase [EC:3.1.6.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
Disease
H00134  X-linked ichthyosis
Drug target
Irosustat: D09915
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    412 (STS)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.6  Sulfuric-ester hydrolases
    3.1.6.2  steryl-sulfatase
     412 (STS)
SSDB
Motif
Pfam: Sulfatase Sulfatase_C SGSH_C Phosphodiest
Other DBs
NCBI-GeneID: 412
NCBI-ProteinID: NP_000342
OMIM: 300747
HGNC: 11425
UniProt: P08842 A0A590UJL0
Structure
Position
X:7147290..7354641
AA seq 578 aa
MKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKL
TQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ
GYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRL
VFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMM
RNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQH
GVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYK
GGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRD
LMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATH
VCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVP
DQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
NT seq 1737 nt   +upstreamnt  +downstreamnt
atgaagatccctttcctcctactgttctttctgtgggaagccgagagccacgcagcatca
aggccgaacatcatcctggtgatggctgacgacctcggcattggagatcctgggtgctat
gggaacaaaactatcaggactcccaatatcgaccggttggccagtgggggagtgaaactc
actcagcacctggcagcatcaccgctgtgcacaccaagcagggcagccttcatgactggc
cggtaccctgtccgatcaggaatggcatcttggtcccgcactggagttttcctcttcaca
gcctcttcgggaggacttcccaccgatgagattacctttgctaagcttctgaaggatcaa
ggttattcaacagcactgatagggaaatggcaccttgggatgagctgtcacagcaagact
gacttctgtcaccaccctttacatcacggcttcaattatttctatgggatctctttgacc
aatctgagagactgcaagcccggagagggcagtgtcttcaccacgggcttcaagaggctg
gtcttcctccccctgcagatcgtcggggtcaccctccttacccttgctgcactcaattgt
ctggggctactccacgtgcctctaggcgtttttttcagccttctcttcctagcagcccta
atcctgacccttttcttgggcttccttcattacttccggcccctgaactgcttcatgatg
aggaactacgagatcattcagcagcccatgtcctatgacaatctcacccagaggctaacg
gtggaggcggcccagttcatacagcggaacactgagactccgttcctgcttgtcttgtcc
tacctccacgtgcacacagccctgttctccagcaaagactttgctggcaaaagtcaacac
ggagtctacggggatgctgttgaggaaatggactggagtgtggggcagatcttgaacctt
ctggatgagctgagattggctaatgataccctcatctacttcacatcggaccagggagca
catgtagaagaagtgtcttccaaaggagaaattcatggcggaagtaatgggatctataaa
ggaggaaaagcaaacaactgggaaggaggtatccgggttccaggcatccttcgttggccc
agggtgatacaggctggccagaagattgatgagcccactagcaacatggacatatttcct
acagtagccaagctggctggagctcccttgcctgaggacaggatcattgatggacgtgat
ctgatgcccctgcttgaaggaaaaagccaacgctccgatcatgagtttctcttccattac
tgcaacgcctacttaaatgctgtgcgctggcaccctcagaacagcacatccatctggaag
gcctttttcttcacccccaacttcaaccccgtgggttccaacggatgctttgccacacac
gtgtgcttctgtttcgggagttatgtcacccatcacgacccacctttactctttgatatt
tccaaagatcccagagagagaaacccactaactccagcatccgagccccggttttatgaa
atcctcaaagtcatgcaggaagctgcggacagacacacccagaccctgccagaggtgccc
gatcagttttcatggaacaactttctttggaagccctggcttcagctgtgctgtccttcc
accggcctgtcttgccagtgtgatagagaaaaacaggataagagactgagccgctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (25)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (70)   
   RefSeq(nuc) (8)   
   GenBank (31)   
   EMBL (31)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (4)   
All databases (114)   

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