KEGG   Homo sapiens (human): 4121
Entry
4121              CDS       T01001                                 

Gene name
MAN1A1, HUMM3, HUMM9, MAN9
Definition
(RefSeq) mannosidase alpha class 1A member 1
  KO
K01230  mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa01100  Metabolic pathways
hsa04141  Protein processing in endoplasmic reticulum
Module
hsa_M00073  N-glycan precursor trimming
Network
nt06015  N-Glycan biosynthesis
  Element
N00820  N-Glycan biosynthesis
N00821  B4GALT1 deficiency in N-glycan biosynthesis
N00822  MGAT2 deficiency in N-glycan biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    4121 (MAN1A1)
   00513 Various types of N-glycan biosynthesis
    4121 (MAN1A1)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    4121 (MAN1A1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4121 (MAN1A1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.113  mannosyl-oligosaccharide 1,2-alpha-mannosidase
     4121 (MAN1A1)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    4121 (MAN1A1)
SSDB
Motif
Pfam: Glyco_hydro_47 DnaB_bind AIM5
Other DBs
NCBI-GeneID: 4121
NCBI-ProteinID: NP_005898
OMIM: 604344
HGNC: 6821
Ensembl: ENSG00000111885
Vega: OTTHUMG00000015472
Pharos: P33908(Tbio)
UniProt: P33908
Position
6q22.31
AA seq 653 aa
MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIF
FLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDN
LARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI
GVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGAT
IVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEI
FRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHL
SHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLL
KAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGG
MFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEK
YYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDD
VQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKDKKEVEIREE
NT seq 1962 nt   +upstreamnt  +downstreamnt
atgcccgtggggggcctgttgccgctcttcagcagccccgcgggcggcgtcctgggcggg
gggctcggcggcggcggtggcaggaaggggtcgggccccgccgccctccgcctgacggag
aagttcgtgctgctgctggtattcagcgccttcatcacgctctgcttcggggcgatcttc
ttcctgccagactcctccaagctgctcagcggggtcctgttccactccagccccgccttg
cagccggccgccgaccacaagcccgggcccggggcgcgcgccgaggacgcggccgagggg
cgagcccggcgccgcgaggagggggcacccggggacccggaggccgccctggaggacaac
ttggccaggatccgcgaaaaccacgagcgggctctcagggaagccaaggagaccctgcag
aagctgcccgaggagatccaaagagacatcctactggagaagaagaaggtggcccaggac
cagctgcgtgacaaggcgccgttcagaggcctgcccccggtggacttcgtgcccccaatc
ggggtggagagccgggagcccgccgacgccgccatccgcgagaaaagggcaaagatcaaa
gagatgatgaaacatgcttggaataattataaaggttatgcctggggattaaatgaactc
aaacctatatcaaaaggaggccattcaagcagtttgtttggtaacatcaaaggagcaact
atagtagatgccctggatacactttttattatggaaatgaaacatgaatttgaagaagca
aaatcatgggttgaagaaaatttagattttaatgtgaatgctgaaatttctgtctttgaa
gtaaatatacgctttgttggtggactactctcagcctactatctgtctggagaagagatt
tttcgaaagaaagcagtggaacttggggtaaaattgctacctgcatttcatactccctct
ggaataccttgggcattgctgaatatgaaaagtggtattggaaggaactggccctgggcc
tctggaggcagcagtattctggcagaatttggaaccctgcatttggagtttatgcacttg
agccacttatcaggaaaccccatctttgctgaaaaggtaatgaatattcgaacagtactg
aacaaactggaaaaaccacaaggcctttatcctaactatctgaatcccagtagtggacag
tggggtcaacatcatgtatcagttggaggacttggagacagcttctatgagtatttgctg
aaggcctggttaatgtctgacaagacagatctggaagctaagaagatgtattttgatgct
gttcaggctatcgagactcatttgatccgcaagtctagcagcggactaacttatatcgca
gagtggaaagggggcctcctggagcacaagatgggccacctgacctgcttcgcggggggc
atgttcgcactcggggctgatgcagctcccgaaggcatggcccaacactaccttgaactc
ggggctgaaattgcccgtacttgtcatgaatcatataatcgaacatttatgaaactggga
ccagaagctttcagatttgatggtggtgttgaagccatcgctacaagacaaaatgaaaaa
tactacatcttacggccagaagttatggagacttacatgtatatgtggagactgactcat
gatccaaagtacaggaaatgggcctgggaagccgtagaggccttggaaaaccattgcaga
gtgaatggaggctattcaggcctaagggatgtttaccttcttcatgagagttatgatgat
gtgcagcagagtttcttcctggcagagacattgaaatatttgtacctaatattttctgac
gacgatcttcttccactggagcattggatcttcaatagcgaggcacatcttctccctatc
ctccctaaagataaaaaggaagttgaaatcagagaggaataa

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