KEGG   Homo sapiens (human): 4124
Entry
4124              CDS       T01001                                 
Symbol
MAN2A1, AMan_II, GOLIM7, MANA2, MANII
Name
(RefSeq) mannosidase alpha class 2A member 1
  KO
K01231  alpha-mannosidase II [EC:3.2.1.114]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00075  N-glycan biosynthesis, complex type
Network
nt06015  N-Glycan biosynthesis
  Element
N00820  N-Glycan biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    4124 (MAN2A1)
   00513 Various types of N-glycan biosynthesis
    4124 (MAN2A1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.114  mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
     4124 (MAN2A1)
SSDB
Motif
Pfam: Glyco_hydro_38N Glyco_hydro_38C Alpha-mann_mid Laman-like_dom Phage_tail_terminator_4 Glyco_hydro_57
Other DBs
NCBI-GeneID: 4124
NCBI-ProteinID: NP_002363
OMIM: 154582
HGNC: 6824
Ensembl: ENSG00000112893
UniProt: Q16706
Position
5:109689927..109869625
AA seq 1144 aa
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR
NT seq 3435 nt   +upstreamnt  +downstreamnt
atgaagttaagccgccagttcaccgtgttcggcagtgcgatcttctgtgtggtgattttc
tcgctctacctgatgctggaccggggtcacttagactaccccaggaacccgcgccgcgag
ggctccttccctcagggccagctctcaatgttgcaagaaaaaatagaccatttggagcgt
ttgctagctgagaataatgagatcatctcaaatattagagactcagtcatcaatttgagt
gagtctgtggaggatggtccgaaaagttcacaaagcaatttcagccaaggtgctggctca
catcttctgccctcacaattatccctctcagttgacactgcagactgtctgtttgcttca
caaagtggaagtcacaattcagatgtgcagatgttggatgtttacagtctaatttctttt
gacaatccagatggtggagtttggaagcaaggatttgacattacttatgaatctaatgaa
tgggacactgaaccccttcaagtctttgtggtgcctcattcccataacgacccaggttgg
ttgaagactttcaatgactactttagagacaagactcagtatatttttaataacatggtc
ctaaagctgaaagaagactcacggaggaagtttatttggtctgagatctcttacctttca
aagtggtgggatattatagatattcagaagaaggatgctgttaaaagtttaatagaaaat
ggtcagcttgaaattgtgacaggtggctgggttatgcctgatgaagctactccacattat
tttgccttaattgatcaactaattgaaggacatcagtggctggaaaataatataggagtg
aaacctcggtccggctgggctattgatccctttggacactcaccaacaatggcttatctt
ctaaaccgtgctggactttctcacatgcttatccagagagttcattatgcagttaaaaaa
cactttgcactgcataaaacattggagtttttttggagacagaattgggatctgggatct
gtcacagatattttatgccacatgatgcccttctacagctatgacatccctcacacttgt
ggacctgatcctaaaatatgctgccagtttgattttaaacgtcttcctggaggcagattt
ggttgtccctggggagtccccccagaaacaatacatcctggaaatgtccaaagcagggct
cggatgctactagatcagtaccgaaagaagtcaaagctttttcgtaccaaagttctcctg
gctccactaggagatgatttccgctactgtgaatacacggaatgggatttacagtttaag
aattatcagcagctttttgattatatgaattctcagtccaagtttaaagttaagatacag
tttggaactttatcagatttttttgatgcgctggataaagcagatgaaactcagagagac
aagggccaatcgatgttccctgttttaagtggagattttttcacttatgccgatcgagat
gatcattactggagtggctattttacatccagacccttttacaaacgaatggacagaatc
atggaatctcatttaagggctgctgaaattctttactatttcgccctgagacaagctcac
aaatacaagataaataaatttctctcatcatcactttacacggcactgacagaagccaga
aggaatttgggactgtttcaacatcatgatgctatcacaggaactgcaaaagactgggtg
gttgtggattatggtaccagactttttcattcgttaatggttttggagaagataattgga
aattctgcatttcttcttattttgaaggacaaactcacatacgactcttactctcctgat
accttcctggagatggatttgaaacaaaaatcacaagattctctgccacaaaaaaatata
ataaggctgagtgcggagccaaggtaccttgtggtctataatcctttagaacaagaccga
atctcgttggtctcagtctatgtgagttccccgacagtgcaagtgttctctgcttcagga
aaacctgtggaagttcaagtcagcgcagtttgggatacagcaaatactatttcagaaaca
gcctatgagatctcttttcgagcacatataccgccattgggactgaaagtgtataagatt
ttggaatcagcaagttcaaattcacatttagctgattatgtcttgtataagaataaagta
gaagatagcggaattttcaccataaagaatatgataaatactgaagaaggtataacacta
gagaactcctttgttttacttcggtttgatcaaactggacttatgaagcaaatgatgact
aaagaagatggtaaacaccatgaagtaaatgtgcaattttcatggtatggaaccacaatt
aaaagagacaaaagtggtgcctacctcttcttacctgatggtaatgccaagccttatgtt
tacacaacaccgccctttgtcagagtgacacatggaaggatttattcggaagtgacttgc
ttttttgaccatgttactcatagagtccgactataccacatacagggaatagaaggacag
tctgtggaagtttccaatattgtggacatccgaaaagtatataaccgtgagattgcaatg
aaaatttcttctgatataaaaagccaaaatagattttatactgacctaaatgggtaccag
attcaacctagaatgacactgagcaaattgcctcttcaagcaaatgtctatcccatgacc
acaatggcctatatccaggatgccaaacatcgtttgacactgctctctgctcagtcatta
ggggtttcgagtttgaatagtggtcagattgaagttatcatggatcgaagactcatgcaa
gatgataatcgtggccttgagcaaggtatccaggataacaagattacagctaatctattt
cgaatactactagaaaaaagaagtgctgttaatacggaagaagaaaagaagtcggtcagt
tatccttctctccttagccacataacttcttctctcatgaatcatccagtcattccaatg
gcaaataagttctcctcacctacccttgagctgcaaggtgaattctctccattacagtca
tctttgccttgtgacattcatctggttaatttgagaacaatacagtcaaaggtgggcaat
gggcactccaatgaggcagccttgatcctccacagaaaagggtttgattgtcggttctct
agcaaaggcacagggctgttttgttctactactcagggaaagatattggtacagaaactt
ttaaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgcattcacct
cccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagcacattccga
atccagttgaggtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (10)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (37)   
   RefSeq(nuc) (9)   
   GenBank (14)   
   EMBL (14)   
Protein domain (6)   
   Pfam (6)   
All databases (63)   

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