KEGG   Homo sapiens (human): 4126
Entry
4126              CDS       T01001                                 
Symbol
MANBA, MANB1
Name
(RefSeq) mannosidase beta
  KO
K01192  beta-mannosidase [EC:3.2.1.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00511  Other glycan degradation
hsa04142  Lysosome
Disease
H00140  beta-Mannosidosis
H00422  Glycoproteinoses
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00511 Other glycan degradation
    4126 (MANBA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    4126 (MANBA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.25  beta-mannosidase
     4126 (MANBA)
SSDB
Motif
Pfam: Glyco_hydro_2_N2 Ig_mannosidase Mannosidase_ig Glyco_hydro_2_C Glyco_hydro_2_N
Other DBs
NCBI-GeneID: 4126
NCBI-ProteinID: NP_005899
OMIM: 609489
HGNC: 6831
Ensembl: ENSG00000109323
UniProt: O00462
Position
4:complement(102630770..102760968)
AA seq 879 aa
MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQD
SYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETD
NMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNF
VRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFD
VVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTG
YNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPA
DSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACA
LYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKD
YVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDC
WNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAG
LHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLN
DIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSV
RVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHE
LLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFS
DNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY
NT seq 2640 nt   +upstreamnt  +downstreamnt
atgcgcctccacctgctcctgctgctcgcgctgtgcggtgcaggcaccaccgccgcggag
ctcagttacagcttgcgtggcaactggagcatctgcaatgggaacggctcgctggagctg
cccggggcggtccctggctgcgtgcacagcgccttgttccagcagggcctgatccaggat
tcttactacagatttaatgaccttaactacagatgggtctctttggataactggacctat
agcaaagaatttaaaatcccctttgaaattagcaaatggcaaaaagtaaatttgattctt
gagggagtggatacggtttcaaaaatcctgttcaatgaagtcactattggggaaacagac
aatatgttcaatagatatagctttgatattaccaacgtggtcagggacgtgaactccatt
gagctgcgtttccagtcagcggtgttgtatgcagcacagcagagcaaagctcacactcgc
taccaggttcccccagactgccctccacttgtgcagaagggtgaatgccatgtcaacttt
gttcggaaggagcaatgttcctttagttgggactgggggccttcctttcctacccaggga
atctggaaagatgttagaattgaagcctataatatttgtcacctgaactacttcacattt
tccccaatatatgataagagtgcccaggagtggaatctggaaatagagtctacatttgat
gttgtcagctcaaagccagttggtggtcaagtgatcgtagccatccctaagttgcaaaca
caacagacatacagcattgaacttcaacctgggaaaaggattgttgagctatttgtgaac
attagcaagaatattactgtagaaacttggtggcctcatggacatggaaaccagactggg
tacaacatgactgttctttttgaactggatggaggcttaaatattgaaaaatcagctaag
gtttattttaggacagtggaacttatagaagagcctataaaagggtctcctggtttgagt
ttctatttcaaaattaatggatttcccatatttctaaaaggctcaaactggatcccagca
gattcattccaggaccgagtaacctctgagttgttacggctccttttacagtctgttgtg
gatgctaatatgaatactcttcgggtttggggaggaggaatttatgagcaggatgaattc
tatgaactctgtgatgaactaggaataatggtatggcaggattttatgtttgcctgtgcc
ctttatccaactgatcagggcttcctggattcagtgacagcagaagttgcctaccagatc
aagagactgaaatctcatccttctatcatcatatggagtggcaataatgaaaatgaggag
gcgctgatgatgaattggtatcatatcagtttcactgaccggccaatctacatcaaggac
tatgtgacactctatgtgaaaaacatcagagagctcgtactggcaggagacaagagtcgt
ccttttattacgtccagtcctacaaatggggctgaaactgttgcagaagcctgggtctct
caaaaccctaatagcaattattttggtgatgtacatttttatgactatatcagtgattgc
tggaactggaaagttttcccaaaagctcgatttgcatctgaatatggatatcagtcctgg
ccgtccttcagtacattagaaaaggtctcgtctacagaggactggtctttcaatagcaag
ttttcacttcatcgacaacatcacgaaggtggtaacaaacaaatgctttatcaggctgga
cttcatttcaaactcccccaaagcacagatccattacgcacatttaaagataccatctac
cttactcaggtgatgcaggcccagtgtgtcaaaacagaaactgaattctaccgccgtagt
cgcagcgagatagtggatcagcaagggcacacgatgggggcactttattggcagttgaat
gacatctggcaagctccttcctgggcttctcttgagtacggaggaaagtggaaaatgctt
cattactttgctcagaatttctttgctccactgttgccagtaggctttgagaatgaaaac
acgttctatatctatggtgtgtcagatcttcactcggattattcgatgacactcagtgtg
agagtccatacatggagctccctggagcccgtgtgctctcgtgtgactgaacgttttgtg
atgaaaggaggagaggctgtctgcctttatgaggagccagtgtctgaattgctgaggaga
tgtgggaattgcacacgggaaagctgtgtggtttccttttacctttcagctgaccatgaa
ctcctgagcccgaccaactaccacttcttgtcctcaccgaaggaggccgtggggctctgc
aaggcgcagatcactgccatcatctctcagcaaggtgacatatttgtttttgacctggag
acctcagctgtcgctccctttgtttggttggatgtaggaagcatcccagggagatttagt
gacaatggtttcctcatgactgagaagacacgaactatattattttacccttgggagccc
accagcaagaatgagttggagcaatcttttcatgtgacctccttaacagatatttactga

  All links  
Disease (2)   
   OMIM (2)   
Gene (26)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (24)   
   RefSeq(nuc) (6)   
   GenBank (9)   
   EMBL (9)   
Protein domain (5)   
   Pfam (5)   
All databases (65)   

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