KEGG   Homo sapiens (human): 4126Help
Entry
4126              CDS       T01001                                 

Gene name
MANBA, MANB1
Definition
(RefSeq) mannosidase beta
  KO
K01192  beta-mannosidase [EC:3.2.1.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00511  Other glycan degradation
hsa04142  Lysosome
Disease
H00140  beta-Mannosidosis
H00422  Glycoproteinoses
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00511 Other glycan degradation
    4126 (MANBA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    4126 (MANBA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.25  beta-mannosidase
     4126 (MANBA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ig_mannosidase Mannosidase_ig Glyco_hydro_2_C Glyco_hydro_2_N
Motif
Other DBs
NCBI-GeneID: 4126
NCBI-ProteinID: NP_005899
OMIM: 609489
HGNC: 6831
Ensembl: ENSG00000109323
Vega: OTTHUMG00000131123
Pharos: O00462(Tchem)
UniProt: O00462
Position
4q24
AA seq 879 aa AA seqDB search
MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQD
SYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETD
NMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNF
VRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFD
VVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTG
YNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPA
DSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACA
LYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKD
YVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDC
WNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAG
LHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLN
DIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSV
RVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHE
LLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFS
DNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY
NT seq 2640 nt NT seq  +upstreamnt  +downstreamnt
atgcgcctccacctgctcctgctgctcgcgctgtgcggtgcaggcaccaccgccgcggag
ctcagttacagcttgcgtggcaactggagcatctgcaatgggaacggctcgctggagctg
cccggggcggtccctggctgcgtgcacagcgccttgttccagcagggcctgatccaggat
tcttactacagatttaatgaccttaactacagatgggtctctttggataactggacctat
agcaaagaatttaaaatcccctttgaaattagcaaatggcaaaaagtaaatttgattctt
gagggagtggatacggtttcaaaaatcctgttcaatgaagtcactattggggaaacagac
aatatgttcaatagatatagctttgatattaccaacgtggtcagggacgtgaactccatt
gagctgcgtttccagtcagcggtgttgtatgcagcacagcagagcaaagctcacactcgc
taccaggttcccccagactgccctccacttgtgcagaagggtgaatgccatgtcaacttt
gttcggaaggagcaatgttcctttagttgggactgggggccttcctttcctacccaggga
atctggaaagatgttagaattgaagcctataatatttgtcacctgaactacttcacattt
tccccaatatatgataagagtgcccaggagtggaatctggaaatagagtctacatttgat
gttgtcagctcaaagccagttggtggtcaagtgatcgtagccatccctaagttgcaaaca
caacagacatacagcattgaacttcaacctgggaaaaggattgttgagctatttgtgaac
attagcaagaatattactgtagaaacttggtggcctcatggacatggaaaccagactggg
tacaacatgactgttctttttgaactggatggaggcttaaatattgaaaaatcagctaag
gtttattttaggacagtggaacttatagaagagcctataaaagggtctcctggtttgagt
ttctatttcaaaattaatggatttcccatatttctaaaaggctcaaactggatcccagca
gattcattccaggaccgagtaacctctgagttgttacggctccttttacagtctgttgtg
gatgctaatatgaatactcttcgggtttggggaggaggaatttatgagcaggatgaattc
tatgaactctgtgatgaactaggaataatggtatggcaggattttatgtttgcctgtgcc
ctttatccaactgatcagggcttcctggattcagtgacagcagaagttgcctaccagatc
aagagactgaaatctcatccttctatcatcatatggagtggcaataatgaaaatgaggag
gcgctgatgatgaattggtatcatatcagtttcactgaccggccaatctacatcaaggac
tatgtgacactctatgtgaaaaacatcagagagctcgtactggcaggagacaagagtcgt
ccttttattacgtccagtcctacaaatggggctgaaactgttgcagaagcctgggtctct
caaaaccctaatagcaattattttggtgatgtacatttttatgactatatcagtgattgc
tggaactggaaagttttcccaaaagctcgatttgcatctgaatatggatatcagtcctgg
ccgtccttcagtacattagaaaaggtctcgtctacagaggactggtctttcaatagcaag
ttttcacttcatcgacaacatcacgaaggtggtaacaaacaaatgctttatcaggctgga
cttcatttcaaactcccccaaagcacagatccattacgcacatttaaagataccatctac
cttactcaggtgatgcaggcccagtgtgtcaaaacagaaactgaattctaccgccgtagt
cgcagcgagatagtggatcagcaagggcacacgatgggggcactttattggcagttgaat
gacatctggcaagctccttcctgggcttctcttgagtacggaggaaagtggaaaatgctt
cattactttgctcagaatttctttgctccactgttgccagtaggctttgagaatgaaaac
acgttctatatctatggtgtgtcagatcttcactcggattattcgatgacactcagtgtg
agagtccatacatggagctccctggagcccgtgtgctctcgtgtgactgaacgttttgtg
atgaaaggaggagaggctgtctgcctttatgaggagccagtgtctgaattgctgaggaga
tgtgggaattgcacacgggaaagctgtgtggtttccttttacctttcagctgaccatgaa
ctcctgagcccgaccaactaccacttcttgtcctcaccgaaggaggccgtggggctctgc
aaggcgcagatcactgccatcatctctcagcaaggtgacatatttgtttttgacctggag
acctcagctgtcgctccctttgtttggttggatgtaggaagcatcccagggagatttagt
gacaatggtttcctcatgactgagaagacacgaactatattattttacccttgggagccc
accagcaagaatgagttggagcaatcttttcatgtgacctccttaacagatatttactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (24)   
   RefSeq(nuc) (6)   
   GenBank (9)   
   EMBL (9)   
Protein domain (4)   
   Pfam (4)   
All databases (76)   

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