KEGG   Homo sapiens (human): 4128
Entry
4128              CDS       T01001                                 
Symbol
MAOA, BRNRS, MAO-A
Name
(RefSeq) monoamine oxidase A
  KO
K00274  monoamine oxidase [EC:1.4.3.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00330  Arginine and proline metabolism
hsa00340  Histidine metabolism
hsa00350  Tyrosine metabolism
hsa00360  Phenylalanine metabolism
hsa00380  Tryptophan metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Module
hsa_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA
Network
nt06028  Dopamine and serotonin metabolism
nt06463  Parkinson disease
nt06544  Neuroactive ligand signaling
  Element
N01039  Mutation-inactivated PRKN to DOPAL generation
N01530  Dopamine metabolism
N01550  Adrenaline metabolism
N01551  Serotonin metabolism
N01918  Dopamine metabolism in astrocyte
N01919  Dopamine/Adrenaline metabolism in presynaptic neuron
Disease
H00548  Brunner syndrome
Drug target
Befloxatone: D02563
Brofaromine: D02560
Caroxazone: D03409
Cimoxatone: D02581
Clorgiline: D03248
Etryptamine acetate: D04092
Iproclozide: D07338
Iproniazide (DG00950): D02579 D08085
Isocarboxazid: D02580
Ladostigil tartrate: D03239
Minaprine (DG00954): D05039 D05040
Moclobemide: D02561
Nialamide: D07337
Pargyline (DG00264): D02564 D08453
Phenelzine (DG00948): D00505<US> D08349
Phentermine (DG00102): D05458 D05459<US>
Pirlindole (DG01277): D08392 D08393
Safrazine hydrochloride: D01888
Toloxatone: D02559
Tranylcypromine (DG00949): D00826<US> D08625
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    4128 (MAOA)
   00330 Arginine and proline metabolism
    4128 (MAOA)
   00340 Histidine metabolism
    4128 (MAOA)
   00350 Tyrosine metabolism
    4128 (MAOA)
   00360 Phenylalanine metabolism
    4128 (MAOA)
   00380 Tryptophan metabolism
    4128 (MAOA)
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    4128 (MAOA)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    4128 (MAOA)
   04726 Serotonergic synapse
    4128 (MAOA)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    4128 (MAOA)
  09165 Substance dependence
   05030 Cocaine addiction
    4128 (MAOA)
   05031 Amphetamine addiction
    4128 (MAOA)
   05034 Alcoholism
    4128 (MAOA)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.4  monoamine oxidase
     4128 (MAOA)
SSDB
Motif
Pfam: Amino_oxidase NAD_binding_8 DAO FAD_binding_3 Pyr_redox_2 FAD_oxidored HI0933_like Pyr_redox FAD_binding_2 Thi4 Pyr_redox_3 AlaDh_PNT_C Lycopene_cycl GIDA MurD-like_N M20_dimer MCRA NAD_binding_9
Other DBs
NCBI-GeneID: 4128
NCBI-ProteinID: NP_000231
OMIM: 309850
HGNC: 6833
Ensembl: ENSG00000189221
UniProt: P21397 Q53YE7 Q49A63
Structure
Position
X:43655006..43746817
AA seq 527 aa
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV
DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL
NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR
LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD
VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
NT seq 1584 nt   +upstreamnt  +downstreamnt
atggagaatcaagagaaggcgagtatcgcgggccacatgttcgacgtagtcgtgatcgga
ggtggcatttcaggactatctgctgccaaactcttgactgaatatggcgttagtgttttg
gttttagaagctcgggacagggttggaggaagaacatatactataaggaatgagcatgtt
gattacgtagatgttggtggagcttatgtgggaccaacccaaaacagaatcttacgcttg
tctaaggagctgggcatagagacttacaaagtgaatgtcagtgagcgtctcgttcaatat
gtcaaggggaaaacatatccatttcggggcgcctttccaccagtatggaatcccattgca
tatttggattacaataatctgtggaggacaatagataacatggggaaggagattccaact
gatgcaccctgggaggctcaacatgctgacaaatgggacaaaatgaccatgaaagagctc
attgacaaaatctgctggacaaagactgctaggcggtttgcttatctttttgtgaatatc
aatgtgacctctgagcctcacgaagtgtctgccctgtggttcttgtggtatgtgaagcag
tgcgggggcaccactcggatattctctgtcaccaatggtggccaggaacggaagtttgta
ggtggatctggtcaagtgagcgaacggataatggacctcctcggagaccaagtgaagctg
aaccatcctgtcactcacgttgaccagtcaagtgacaacatcatcatagagacgctgaac
catgaacattatgagtgcaaatacgtaattaatgcgatccctccgaccttgactgccaag
attcacttcagaccagagcttccagcagagagaaaccagttaattcagcggcttccaatg
ggagctgtcattaagtgcatgatgtattacaaggaggccttctggaagaagaaggattac
tgtggctgcatgatcattgaagatgaagatgctccaatttcaataaccttggatgacacc
aagccagatgggtcactgcctgccatcatgggcttcattcttgcccggaaagctgatcga
cttgctaagctacataaggaaataaggaagaagaaaatctgtgagctctatgccaaagtg
ctgggatcccaagaagctttacatccagtgcattatgaagagaagaactggtgtgaggag
cagtactctgggggctgctacacggcctacttccctcctgggatcatgactcaatatgga
agggtgattcgtcaacccgtgggcaggattttctttgcgggcacagagactgccacaaag
tggagcggctacatggaaggggcagttgaggctggagaacgagcagctagggaggtctta
aatggtctcgggaaggtgaccgagaaagatatctgggtacaagaacctgaatcaaaggac
gttccagcggtagaaatcacccacaccttctgggaaaggaacctgccctctgtttctggc
ctgctgaagatcattggattttccacatcagtaactgccctggggtttgtgctgtacaaa
tacaagctcctgccacggtcttga

  All links  
Disease (2)   
   OMIM (2)   
Gene (18)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (18)   
   Pfam (18)   
All databases (74)   

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