KEGG   Homo sapiens (human): 4157
Entry
4157              CDS       T01001                                 

Gene name
MC1R, CMM5, MSH-R, SHEP2
Definition
(RefSeq) melanocortin 1 receptor
  KO
K04199  melanocortin 1 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04916  Melanogenesis
Disease
H00168  Oculocutaneous albinism
Drug target
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4157 (MC1R)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    4157 (MC1R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4157 (MC1R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4157 (MC1R)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx 7TM_GPCR_Srx Pox_A14
Other DBs
NCBI-GeneID: 4157
NCBI-ProteinID: NP_002377
OMIM: 155555
HGNC: 6929
Ensembl: ENSG00000258839
Vega: OTTHUMG00000171163
Pharos: Q01726(Tclin)
UniProt: Q01726 Q1JUL4
Position
16q24.3
AA seq 317 aa
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
NT seq 954 nt   +upstreamnt  +downstreamnt
atggctgtgcagggatcccagagaagacttctgggctccctcaactccacccccacagcc
atcccccagctggggctggctgccaaccagacaggagcccggtgcctggaggtgtccatc
tctgacgggctcttcctcagcctggggctggtgagcttggtggagaacgcgctggtggtg
gccaccatcgccaagaaccggaacctgcactcacccatgtactgcttcatctgctgcctg
gccttgtcggacctgctggtgagcgggagcaacgtgctggagacggccgtcatcctcctg
ctggaggccggtgcactggtggcccgggctgcggtgctgcagcagctggacaatgtcatt
gacgtgatcacctgcagctccatgctgtccagcctctgcttcctgggcgccatcgccgtg
gaccgctacatctccatcttctacgcactgcgctaccacagcatcgtgaccctgccgcgg
gcgcggcgagccgttgcggccatctgggtggccagtgtcgtcttcagcacgctcttcatc
gcctactacgaccacgtggccgtcctgctgtgcctcgtggtcttcttcctggctatgctg
gtgctcatggccgtgctgtacgtccacatgctggcccgggcctgccagcacgcccagggc
atcgcccggctccacaagaggcagcgcccggtccaccagggctttggccttaaaggcgct
gtcaccctcaccatcctgctgggcattttcttcctctgctggggccccttcttcctgcat
ctcacactcatcgtcctctgccccgagcaccccacgtgcggctgcatcttcaagaacttc
aacctctttctcgccctcatcatctgcaatgccatcatcgaccccctcatctacgccttc
cacagccaggagctccgcaggacgctcaaggaggtgctgacatgctcctggtga

KEGG   Homo sapiens (human): 4159
Entry
4159              CDS       T01001                                 

Gene name
MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL
Definition
(RefSeq) melanocortin 3 receptor
  KO
K04201  melanocortin 3 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H02106  Genetic obesity
Drug target
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4159 (MC3R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4159 (MC3R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4159 (MC3R)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 4159
NCBI-ProteinID: NP_063941
OMIM: 155540
HGNC: 6931
Ensembl: ENSG00000124089
Vega: OTTHUMG00000032785
Pharos: P41968(Tchem)
UniProt: P41968
Position
20q13.2
AA seq 323 aa
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
NT seq 972 nt   +upstreamnt  +downstreamnt
atgaatgcttcgtgctgcctgccctctgttcagccaacactgcctaatggctcggagcac
ctccaagcccctttcttcagcaaccagagcagcagcgccttctgtgagcaggtcttcatc
aagcccgaggttttcctgtctctgggcatcgtcagtctgctggaaaacatcctggttatc
ctggccgtggtcaggaacggcaacctgcactccccgatgtacttctttctctgcagcctg
gcggtggccgacatgctggtaagtgtgtccaatgccctggagaccatcatgatcgccatc
gtccacagcgactacctgaccttcgaggaccagtttatccagcacatggacaacatcttc
gactccatgatctgcatctccctggtggcctccatctgcaacctcctggccatcgccgtc
gacaggtacgtcaccatcttttacgcgctccgctaccacagcatcatgaccgtgaggaag
gccctcaccttgatcgtggccatctgggtctgctgcggcgtctgtggcgtggtgttcatc
gtctactcggagagcaaaatggtcattgtgtgcctcatcaccatgttcttcgccatgatg
ctcctcatgggcaccctctacgtgcacatgttcctctttgcgcggctgcacgtcaagcgc
atagcagcactgccacctgccgacggggtggccccacagcaacactcatgcatgaagggg
gcagtcaccatcaccattctcctgggcgtgttcatcttctgctgggcccccttcttcctc
cacctggtcctcatcatcacctgccccaccaacccctactgcatctgctacactgcccac
ttcaacacctacctggtcctcatcatgtgcaactccgtcatcgacccactcatctacgct
ttccggagcctggaattgcgcaacacctttagggagattctctgtggctgcaacggcatg
aacttgggatag

KEGG   Homo sapiens (human): 4160
Entry
4160              CDS       T01001                                 

Gene name
MC4R, BMIQ20
Definition
(RefSeq) melanocortin 4 receptor
  KO
K04202  melanocortin 4 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H02106  Genetic obesity
Drug target
Bremelanotide (DG03063): D06569 D11629<US>
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Setmelanotide (DG03132): D11927 D11928<US> D11929
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4160 (MC4R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4160 (MC4R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4160 (MC4R)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 4160
NCBI-ProteinID: NP_005903
OMIM: 155541
HGNC: 6932
Ensembl: ENSG00000166603
Vega: OTTHUMG00000132766
Pharos: P32245(Tchem)
UniProt: P32245
Position
18q21.32
AA seq 332 aa
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
NT seq 999 nt   +upstreamnt  +downstreamnt
atggtgaactccacccaccgtgggatgcacacttctctgcacctctggaaccgcagcagt
tacagactgcacagcaatgccagtgagtcccttggaaaaggctactctgatggagggtgc
tacgagcaactttttgtctctcctgaggtgtttgtgactctgggtgtcatcagcttgttg
gagaatatcttagtgattgtggcaatagccaagaacaagaatctgcattcacccatgtac
tttttcatctgcagcttggctgtggctgatatgctggtgagcgtttcaaatggatcagaa
accattgtcatcaccctattaaacagtacagatacggatgcacagagtttcacagtgaat
attgataatgtcattgactcggtgatctgtagctccttgcttgcatccatttgcagcctg
ctttcaattgcagtggacaggtactttactatcttctatgctctccagtaccataacatt
atgacagttaagcgggttgggatcatcataagttgtatctgggcagcttgcacggtttca
ggcattttgttcatcatttactcagatagtagtgctgtcatcatctgcctcatcaccatg
ttcttcaccatgctggctctcatggcttctctctatgtccacatgttcctgatggccagg
cttcacattaagaggattgctgtcctccccggcactggtgccatccgccaaggtgccaat
atgaagggagcgattaccttgaccatcctgattggcgtctttgttgtctgctgggcccca
ttcttcctccacttaatattctacatctcttgtcctcagaatccatattgtgtgtgcttc
atgtctcactttaacttgtatctcatactgatcatgtgtaattcaatcatcgatcctctg
atttatgcactccggagtcaagaactgaggaaaaccttcaaagagatcatctgttgctat
cccctgggaggcctttgtgacttgtctagcagatattaa

KEGG   Homo sapiens (human): 4161
Entry
4161              CDS       T01001                                 

Gene name
MC5R, MC2
Definition
(RefSeq) melanocortin 5 receptor
  KO
K04203  melanocortin 5 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4161 (MC5R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4161 (MC5R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4161 (MC5R)
SSDB
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 4161
NCBI-ProteinID: NP_005904
OMIM: 600042
HGNC: 6933
Ensembl: ENSG00000176136
Vega: OTTHUMG00000131720
Pharos: P33032(Tchem)
UniProt: P33032
Position
18p11.21
AA seq 325 aa
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
NT seq 978 nt   +upstreamnt  +downstreamnt
atgaattcctcatttcacctgcatttcttggatctcaacctgaatgccacagagggcaac
ctttcaggacccaatgtcaaaaacaagtcttcaccatgtgaagacatgggcattgctgtg
gaggtgtttctcactctgggtgtcatcagcctcttggagaacatcttggtcataggggcc
atagtgaagaacaaaaacctgcactcccccatgtacttcttcgtgtgcagcctggcagtg
gcggacatgctggtgagcatgtccagtgcctgggagaccatcaccatctacctactcaac
aacaagcacctagtgatagcagacgcctttgtgcgccacattgacaatgtgtttgactcc
atgatctgcatttccgtggtggcatccatgtgcagcttactggccattgcagtggatagg
tacgtcaccatcttctacgccctgcgctaccaccacatcatgacggcgaggcgctcaggg
gccatcatcgccggcatctgggctttctgcacgggctgcggcattgtcttcatcctgtac
tcagaatccacctacgtcatcctgtgcctcatctccatgttcttcgctatgctgttcctc
ctggtgtctctgtacatacacatgttcctcctggcgcggactcacgtcaagcggatcgcg
gctctgcccggggccagctctgcgcggcagaggaccagcatgcagggcgcggtcaccgtc
accatgctgctgggcgtgtttaccgtgtgctgggccccgttcttccttcatctcacttta
atgctttcttgccctcagaacctctactgctctcgcttcatgtctcacttcaatatgtac
ctcatactcatcatgtgtaattccgtgatggaccctctcatatatgccttccgcagccaa
gagatgcggaagacctttaaggagattatttgctgccgtggtttcaggatcgcctgcagc
tttcccagaagggattaa

DBGET integrated database retrieval system