KEGG   Homo sapiens (human): 4160
Entry
4160              CDS       T01001                                 
Symbol
MC4R, BMIQ20
Name
(RefSeq) melanocortin 4 receptor
  KO
K04202  melanocortin 4 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H02106  Genetic obesity
Drug target
Bremelanotide (DG03063): D06569 D11629<US>
Setmelanotide (DG03132): D11927 D11928<US> D11929
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4160 (MC4R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4160 (MC4R)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Melanocortin
    4160 (MC4R)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4
Other DBs
NCBI-GeneID: 4160
NCBI-ProteinID: NP_005903
OMIM: 155541
HGNC: 6932
Ensembl: ENSG00000166603
Pharos: P32245(Tchem)
UniProt: P32245
Structure
Position
18:complement(60371062..60372775)
AA seq 332 aa
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
NT seq 999 nt   +upstreamnt  +downstreamnt
atggtgaactccacccaccgtgggatgcacacttctctgcacctctggaaccgcagcagt
tacagactgcacagcaatgccagtgagtcccttggaaaaggctactctgatggagggtgc
tacgagcaactttttgtctctcctgaggtgtttgtgactctgggtgtcatcagcttgttg
gagaatatcttagtgattgtggcaatagccaagaacaagaatctgcattcacccatgtac
tttttcatctgcagcttggctgtggctgatatgctggtgagcgtttcaaatggatcagaa
accattgtcatcaccctattaaacagtacagatacggatgcacagagtttcacagtgaat
attgataatgtcattgactcggtgatctgtagctccttgcttgcatccatttgcagcctg
ctttcaattgcagtggacaggtactttactatcttctatgctctccagtaccataacatt
atgacagttaagcgggttgggatcatcataagttgtatctgggcagcttgcacggtttca
ggcattttgttcatcatttactcagatagtagtgctgtcatcatctgcctcatcaccatg
ttcttcaccatgctggctctcatggcttctctctatgtccacatgttcctgatggccagg
cttcacattaagaggattgctgtcctccccggcactggtgccatccgccaaggtgccaat
atgaagggagcgattaccttgaccatcctgattggcgtctttgttgtctgctgggcccca
ttcttcctccacttaatattctacatctcttgtcctcagaatccatattgtgtgtgcttc
atgtctcactttaacttgtatctcatactgatcatgtgtaattcaatcatcgatcctctg
atttatgcactccggagtcaagaactgaggaaaaccttcaaagagatcatctgttgctat
cccctgggaggcctttgtgacttgtctagcagatattaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (5)   
   KEGG DRUG (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (8)   
   PDB (8)   
Protein domain (3)   
   Pfam (3)   
All databases (50)   

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