KEGG   Homo sapiens (human): 4160Help
Entry
4160              CDS       T01001                                 

Gene name
MC4R
Definition
(RefSeq) melanocortin 4 receptor
  KO
K04202  melanocortin 4 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H02106  Genetic obesity
Drug target
Alsactide: D07417
Bremelanotide: D06569
Giractide (DG01344): D09801 D09937
Seractide acetate: D05827
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4160 (MC4R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4160 (MC4R)
G protein-coupled receptors [BR:hsa04030]
 Class A. Rhodopsin family
  Pituitary hormone
   Melanocortin
    4160 (MC4R)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7tm_4 7TM_GPCR_Srsx 7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID: 4160
NCBI-ProteinID: NP_005903
OMIM: 155541
HGNC: 6932
Ensembl: ENSG00000166603
Vega: OTTHUMG00000132766
Pharos: P32245(Tchem)
UniProt: P32245
Position
18q21.32
AA seq 332 aa AA seqDB search
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
NT seq 999 nt NT seq  +upstreamnt  +downstreamnt
atggtgaactccacccaccgtgggatgcacacttctctgcacctctggaaccgcagcagt
tacagactgcacagcaatgccagtgagtcccttggaaaaggctactctgatggagggtgc
tacgagcaactttttgtctctcctgaggtgtttgtgactctgggtgtcatcagcttgttg
gagaatatcttagtgattgtggcaatagccaagaacaagaatctgcattcacccatgtac
tttttcatctgcagcttggctgtggctgatatgctggtgagcgtttcaaatggatcagaa
accattgtcatcaccctattaaacagtacagatacggatgcacagagtttcacagtgaat
attgataatgtcattgactcggtgatctgtagctccttgcttgcatccatttgcagcctg
ctttcaattgcagtggacaggtactttactatcttctatgctctccagtaccataacatt
atgacagttaagcgggttgggatcatcataagttgtatctgggcagcttgcacggtttca
ggcattttgttcatcatttactcagatagtagtgctgtcatcatctgcctcatcaccatg
ttcttcaccatgctggctctcatggcttctctctatgtccacatgttcctgatggccagg
cttcacattaagaggattgctgtcctccccggcactggtgccatccgccaaggtgccaat
atgaagggagcgattaccttgaccatcctgattggcgtctttgttgtctgctgggcccca
ttcttcctccacttaatattctacatctcttgtcctcagaatccatattgtgtgtgcttc
atgtctcactttaacttgtatctcatactgatcatgtgtaattcaatcatcgatcctctg
atttatgcactccggagtcaagaactgaggaaaaccttcaaagagatcatctgttgctat
cccctgggaggcctttgtgacttgtctagcagatattaa

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