KEGG T01001: 4233

nt06110  MAPK signaling (viruses and bacteria)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06210  ERK signaling
nt06214  PI3K signaling
nt06240  Transcription
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer

Element

N00005

Mutation-activated MET to RAS-ERK signaling pathway

N00043

HGF-MET-PI3K signaling pathway

N00044

Mutation-activated MET to PI3K signaling pathway

N00143

ASPL-TFE3 fusion to transcriptional activation

N00216

HGF-MET-RAS-ERK signaling pathway

N00246

HGF-overexpression to RAS-ERK signaling pathway

N00247

HGF-overexpression to PI3K signaling pathway

N00248

MET-overexpression to RAS-ERK signaling pathway

N00249

MET-overexpression to PI3K signaling pathway

N00259

Amplified MET to RAS-ERK signaling pathway

N00260

Amplified MET to PI3K signaling pathway

N01062

Mutation-activated MET to RAS-ERK signaling pathway

N01063

Mutation-activated MET to PI3K signaling pathway

N10024

Tyrosine kinase inhibitor to MET exon 14 skipping

Disease

H00014

Non-small cell lung cancer

H00018

Gastric cancer

H00021

Renal cell carcinoma

H00046

Cholangiocarcinoma

H00048

Hepatocellular carcinoma

H00605

Deafness, autosomal recessive

H01985

Desmoplastic small round cell tumor

Drug target

Altiratinib:

D10862

Amivantamab:

D11894<US>

Amuvatinib (DG01916):

D09864 D09865

Cabozantinib (DG01670):

D10062 D10095<JP/US>

Capmatinib (DG02081):

D10696 D10891<JP/US>

Foretinib:

D09618

Glesatinib:

D11136

Golvatinib (DG01367):

Merestinib:

Onartuzumab:

Savolitinib:

Sitravatinib (DG03045):

D11140 D11541

Telisotuzumab:

D11307

Telisotuzumab vedotin:

D11344

Tepotinib (DG03087):

D11073<JP> D11717

Tivantinib:

D10173

Vebreltinib:

D12053

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4233 (MET)
   04014 Ras signaling pathway
    4233 (MET)
   04015 Rap1 signaling pathway
    4233 (MET)
   04020 Calcium signaling pathway
    4233 (MET)
   04151 PI3K-Akt signaling pathway
    4233 (MET)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    4233 (MET)
   04520 Adherens junction
    4233 (MET)
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    4233 (MET)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4233 (MET)
   05202 Transcriptional misregulation in cancer
    4233 (MET)
   05206 MicroRNAs in cancer
    4233 (MET)
   05205 Proteoglycans in cancer
    4233 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    4233 (MET)
   05230 Central carbon metabolism in cancer
    4233 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4233 (MET)
   05226 Gastric cancer
    4233 (MET)
   05218 Melanoma
    4233 (MET)
   05211 Renal cell carcinoma
    4233 (MET)
   05223 Non-small cell lung cancer
    4233 (MET)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    4233 (MET)
   05100 Bacterial invasion of epithelial cells
    4233 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    4233 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    4233 (MET)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4233 (MET)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     4233 (MET)
Protein kinases [BR:hsa01001]
Receptor tyrosine kinases (RTK)
  MET family
   4233 (MET)

Motif

Pfam:

PK_Tyr_Ser-Thr Sema TIG Pkinase PSI Pkinase_fungal Kinase-like

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P08581(Tclin)

UniProt:

P08581 A0A024R759

Structure

PDB:

4R1V 3ZCL 3F66 3DKC 3Q6U 4MXC 5HTI 6SDC 5HNI 5EOB 4XMO 3Q6W 5EYC 4AP7 4EEV 3ZXZ 3DKF 1R1W 1R0P 5EYD 4XYF 3ZZE 5YA5 5UAB 4AOI 3CCN 3DKG 6SDD 3RHK 5HO6 5HLW 4IWD 5T3Q 4R1Y 4DEG 4DEH 3U6H 3QTI 3I5N 2WGJ 2WD1 3CD8 3LQ8 4DEI 3VW8 3U6I 5HOA 2G15 3C1X 5HOR 3ZC5 3ZBX 2WKM 3EFK 2RFS 5UAD 5UAF 4GG7 3R7O 3CTH 6SD9 4KNB 3L8V 3CE3 4GG5 6SDE 3F82 3CTJ 2RFN 3A4P 5DG5 3EFJ 5LSP 4K3J 2UZX 4O3T 4O3U 6I04 1SHY 2UZY 6GCU 1SSL

Position

7q31.2

AA seq 1390 aa
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS

NT seq 4173 nt +upstreamnt +downstreamnt
atgaaggcccccgctgtgcttgcacctggcatcctcgtgctcctgtttaccttggtgcag
aggagcaatggggagtgtaaagaggcactagcaaagtccgagatgaatgtgaatatgaag
tatcagcttcccaacttcaccgcggaaacacccatccagaatgtcattctacatgagcat
cacattttccttggtgccactaactacatttatgttttaaatgaggaagaccttcagaag
gttgctgagtacaagactgggcctgtgctggaacacccagattgtttcccatgtcaggac
tgcagcagcaaagccaatttatcaggaggtgtttggaaagataacatcaacatggctcta
gttgtcgacacctactatgatgatcaactcattagctgtggcagcgtcaacagagggacc
tgccagcgacatgtctttccccacaatcatactgctgacatacagtcggaggttcactgc
atattctccccacagatagaagagcccagccagtgtcctgactgtgtggtgagcgccctg
ggagccaaagtcctttcatctgtaaaggaccggttcatcaacttctttgtaggcaatacc
ataaattcttcttatttcccagatcatccattgcattcgatatcagtgagaaggctaaag
gaaacgaaagatggttttatgtttttgacggaccagtcctacattgatgttttacctgag
ttcagagattcttaccccattaagtatgtccatgcctttgaaagcaacaattttatttac
ttcttgacggtccaaagggaaactctagatgctcagacttttcacacaagaataatcagg
ttctgttccataaactctggattgcattcctacatggaaatgcctctggagtgtattctc
acagaaaagagaaaaaagagatccacaaagaaggaagtgtttaatatacttcaggctgcg
tatgtcagcaagcctggggcccagcttgctagacaaataggagccagcctgaatgatgac
attcttttcggggtgttcgcacaaagcaagccagattctgccgaaccaatggatcgatct
gccatgtgtgcattccctatcaaatatgtcaacgacttcttcaacaagatcgtcaacaaa
aacaatgtgagatgtctccagcatttttacggacccaatcatgagcactgctttaatagg
acacttctgagaaattcatcaggctgtgaagcgcgccgtgatgaatatcgaacagagttt
accacagctttgcagcgcgttgacttattcatgggtcaattcagcgaagtcctcttaaca
tctatatccaccttcattaaaggagacctcaccatagctaatcttgggacatcagagggt
cgcttcatgcaggttgtggtttctcgatcaggaccatcaacccctcatgtgaattttctc
ctggactcccatccagtgtctccagaagtgattgtggagcatacattaaaccaaaatggc
tacacactggttatcactgggaagaagatcacgaagatcccattgaatggcttgggctgc
agacatttccagtcctgcagtcaatgcctctctgccccaccctttgttcagtgtggctgg
tgccacgacaaatgtgtgcgatcggaggaatgcctgagcgggacatggactcaacagatc
tgtctgcctgcaatctacaaggttttcccaaatagtgcaccccttgaaggagggacaagg
ctgaccatatgtggctgggactttggatttcggaggaataataaatttgatttaaagaaa
actagagttctccttggaaatgagagctgcaccttgactttaagtgagagcacgatgaat
acattgaaatgcacagttggtcctgccatgaataagcatttcaatatgtccataattatt
tcaaatggccacgggacaacacaatacagtacattctcctatgtggatcctgtaataaca
agtatttcgccgaaatacggtcctatggctggtggcactttacttactttaactggaaat
tacctaaacagtgggaattctagacacatttcaattggtggaaaaacatgtactttaaaa
agtgtgtcaaacagtattcttgaatgttataccccagcccaaaccatttcaactgagttt
gctgttaaattgaaaattgacttagccaaccgagagacaagcatcttcagttaccgtgaa
gatcccattgtctatgaaattcatccaaccaaatcttttattagtggtgggagcacaata
acaggtgttgggaaaaacctgaattcagttagtgtcccgagaatggtcataaatgtgcat
gaagcaggaaggaactttacagtggcatgtcaacatcgctctaattcagagataatctgt
tgtaccactccttccctgcaacagctgaatctgcaactccccctgaaaaccaaagccttt
ttcatgttagatgggatcctttccaaatactttgatctcatttatgtacataatcctgtg
tttaagccttttgaaaagccagtgatgatctcaatgggcaatgaaaatgtactggaaatt
aagggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaataag
agctgtgagaatatacacttacattctgaagccgttttatgcacggtccccaatgacctg
ctgaaattgaacagcgagctaaatatagagtggaagcaagcaatttcttcaaccgtcctt
ggaaaagtaatagttcaaccagatcagaatttcacaggattgattgctggtgttgtctca
atatcaacagcactgttattactacttgggtttttcctgtggctgaaaaagagaaagcaa
attaaagatctgggcagtgaattagttcgctacgatgcaagagtacacactcctcatttg
gataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaatct
gtagactaccgagctacttttccagaagatcagtttcctaattcatctcagaacggttca
tgccgacaagtgcagtatcctctgacagacatgtcccccatcctaactagtggggactct
gatatatccagtccattactgcaaaatactgtccacattgacctcagtgctctaaatcca
gagctggtccaggcagtgcagcatgtagtgattgggcccagtagcctgattgtgcatttc
aatgaagtcataggaagagggcattttggttgtgtatatcatgggactttgttggacaat
gatggcaagaaaattcactgtgctgtgaaatccttgaacagaatcactgacataggagaa
gtttcccaatttctgaccgagggaatcatcatgaaagattttagtcatcccaatgtcctc
tcgctcctgggaatctgcctgcgaagtgaagggtctccgctggtggtcctaccatacatg
aaacatggagatcttcgaaatttcattcgaaatgagactcataatccaactgtaaaagat
cttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaagttt
gtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcacagtcaaggtt
gctgattttggtcttgccagagacatgtatgataaagaatactatagtgtacacaacaaa
acaggtgcaaagctgccagtgaagtggatggctttggaaagtctgcaaactcaaaagttt
accaccaagtcagatgtgtggtcctttggcgtgctcctctgggagctgatgacaagagga
gccccaccttatcctgacgtaaacacctttgatataactgtttacttgttgcaagggaga
agactcctacaacccgaatactgcccagaccccttatatgaagtaatgctaaaatgctgg
caccctaaagccgaaatgcgcccatccttttctgaactggtgtcccggatatcagcgatc
ttctctactttcattggggagcactatgtccatgtgaacgctacttatgtgaacgtaaaa
tgtgtcgctccgtatccttctctgttgtcatcagaagataacgctgatgatgaggtggac
acacgaccagcctccttctgggagacatcatag

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