KEGG   Homo sapiens (human): 4306
Entry
4306              CDS       T01001                                 

Gene name
NR3C2, MCR, MLR, MR, NR3C2VIT
Definition
(RefSeq) nuclear receptor subfamily 3 group C member 2
  KO
K08555  mineralocorticoid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04960  Aldosterone-regulated sodium reabsorption
Disease
H00243  Hyperkalemic distal renal tubular acidosis (RTA type 4)
H00603  Hypertension exacerbated in pregnancy
H01633  High blood pressure
H02310  Renal tubular acidosis
Drug target
Aldosterone: D10528
Canrenone: D03363
Desoxycortone (DG00507): D03698 D03699 D07792
Dicirenone: D03792
Drospirenone: D03917<US>
Eplerenone: D01115<JP/US>
Esaxerenone: D10892<JP>
Finerenone: D10633
Fludrocortisone (DG00506): D00986<JP/US> D07967
Mexrenoate potassium: D05020
Miricorilant: D11667
Potassium canrenoate: D01943<JP>
Prorenoate potassium: D05640
Spironolactone: D00443<JP/US>
Spiroxasone: D05912
Triamterene: D00386<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    4306 (NR3C2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4306 (NR3C2)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    4306 (NR3C2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    4306 (NR3C2)
Nuclear receptors [BR:hsa03310]
 3. Estrogen like
  3C. 3-Ketosteroid receptor
   4306 (NR3C2)
SSDB
Motif
Pfam: Hormone_recep zf-C4
Other DBs
NCBI-GeneID: 4306
NCBI-ProteinID: NP_000892
OMIM: 600983
HGNC: 7979
Ensembl: ENSG00000151623
Vega: OTTHUMG00000161455
Pharos: P08235(Tclin)
UniProt: P08235 B0ZBF6
Structure
PDB: 

Position
4q31.23
AA seq 984 aa
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
NT seq 2955 nt   +upstreamnt  +downstreamnt
atggagaccaaaggctaccacagtctccctgaaggtctagatatggaaagacggtggggt
caagtttctcaggctgtggagcgttcttccctgggacctacagagaggaccgatgagaat
aactacatggagattgtcaacgtaagctgtgtttccggtgctattccaaacaacagtact
caaggaagcagcaaagaaaaacaagaactactcccttgccttcagcaagacaataatcgg
cctgggattttaacatctgatattaaaactgagctggaatctaaggaactttcagcaact
gtagctgagtccatgggtttatatatggattctgtaagagatgctgactattcctatgag
cagcagaaccaacaaggaagcatgagtccagctaagatttatcagaatgttgaacagctg
gtgaaattttacaaaggaaatggccatcgtccttccactctaagttgtgtgaacacgccc
ttgagatcatttatgtctgactctgggagctccgtgaatggtggcgtcatgcgcgccgtt
gttaaaagccctatcatgtgtcatgagaaaagcccgtctgtttgcagccctctgaacatg
acatcttcggtttgcagccctgctggaatcaactctgtgtcctccaccacagccagcttt
ggcagttttccagtgcacagcccaatcacccagggaactcctctgacatgctcccctaat
gttgaaaatcgaggctccaggtcgcacagccctgcacatgctagcaatgtgggctctcct
ctctcaagtccgttaagtagcatgaaatcctcaatttccagccctccaagtcactgcagt
gtaaaatctccagtctccagtcccaataatgtcactctgagatcctctgtgtctagccct
gcaaatattaacaactcaaggtgctctgtttccagcccttcgaacactaataacagatcc
acgctttccagtccggcagccagtactgtgggatctatctgtagccctgtaaacaatgcc
ttcagctacactgcttctggcacctctgctggatccagtacattgcgggatgtggttccc
agtccagacacgcaggagaaaggtgctcaagaggtcccttttcctaagactgaggaagta
gagagtgccatctcaaatggtgtgactggccagcttaatattgtccagtacataaaacca
gaaccagatggagcttttagcagctcatgtctaggaggaaatagcaaaataaattcggat
tcttcattctcagtaccaataaagcaagaatcaaccaagcattcatgttcaggcacctct
tttaaagggaatccaacagtaaacccgtttccatttatggatggctcgtatttttccttt
atggatgataaagactattattccctatcaggaattttaggaccacctgtgcccggcttt
gatggtaactgtgaaggcagcggattcccagtgggtattaaacaagaaccagatgatggg
agctattacccagaggccagcatcccttcctctgctattgttggggtgaattcaggtgga
cagtccttccactacaggattggtgctcaaggtacaatatctttatcacgatcggctaga
gaccaatctttccaacacctgagttcctttcctcctgtcaatactttagtggagtcatgg
aaatcacacggcgacctgtcgtctagaagaagtgatgggtatccggtcttagaatacatt
ccagaaaatgtatcaagctctactttacgaagtgtttctactggatcttcaagaccttca
aaaatatgtttggtgtgtggggatgaggcttcaggatgccattatggggtagtcacctgt
ggcagctgcaaagttttcttcaaaagagcagtggaagggcaacacaactatttatgtgct
ggaagaaatgattgcatcattgataagattcgacgaaagaattgtcctgcttgcagactt
cagaaatgtcttcaagctggaatgaatttaggagcacgaaagtcaaagaagttgggaaag
ttaaaagggattcacgaggagcagccacagcagcagcagcccccacccccacccccaccc
ccgcaaagcccagaggaagggacaacgtacatcgctcctgcaaaagaaccctcggtcaac
acagcactggttcctcagctctccacaatctcacgagcgctcacaccttcccccgttatg
gtccttgaaaacattgaacctgaaattgtatatgcaggctatgacagctcaaaaccagat
acagccgaaaatctgctctccacgctcaaccgcttagcaggcaaacagatgatccaagtc
gtgaagtgggcaaaggtacttccaggatttaaaaacttgcctcttgaggaccaaattacc
ctaatccagtattcttggatgtgtctatcatcatttgccttgagctggagatcgtacaaa
catacgaacagccaatttctctattttgcaccagacctagtctttaatgaagagaagatg
catcagtctgccatgtatgaactatgccaggggatgcaccaaatcagccttcagttcgtt
cgactgcagctcacctttgaagaatacaccatcatgaaagttttgctgctactaagcaca
attccaaaggatggcctcaaaagccaggctgcatttgaagaaatgaggacaaattacatc
aaagaactgaggaagatggtaactaagtgtcccaacaattctgggcagagctggcagagg
ttctaccaactgaccaagctgctggactccatgcatgacctggtgagcgacctgctggaa
ttctgcttctacaccttccgagagtcccatgcgctgaaggtagagttccccgcaatgctg
gtggagatcatcagcgaccagctgcccaaggtggagtcggggaacgccaagccgctctac
ttccaccggaagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (7)   
   KEGG DISEASE (4)   
   OMIM (3)   
Drug (19)   
   KEGG DRUG (19)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (26)   
   RefSeq(nuc) (6)   
   GenBank (10)   
   EMBL (10)   
Protein domain (2)   
   Pfam (2)   
All databases (85)   

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