KEGG   Homo sapiens (human): 4312
Entry
4312              CDS       T01001                                 
Symbol
MMP1, CLG, CLGN
Name
(RefSeq) matrix metallopeptidase 1
  KO
K01388  matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04657  IL-17 signaling pathway
hsa04926  Relaxin signaling pathway
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05219  Bladder cancer
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
  Element
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Disease
H00028  Choriocarcinoma
H01714  Chronic obstructive pulmonary disease (COPD)
Drug target
Cipemastat: D03517
Diclofenac etalhyaluronate (DG02959): D11020<JP>
Marimastat: D03795
Rebimastat: D03800
Tanomastat: D03802
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    4312 (MMP1)
  09152 Endocrine system
   03320 PPAR signaling pathway
    4312 (MMP1)
   04926 Relaxin signaling pathway
    4312 (MMP1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4312 (MMP1)
  09162 Cancer: specific types
   05219 Bladder cancer
    4312 (MMP1)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    4312 (MMP1)
  09163 Immune disease
   05323 Rheumatoid arthritis
    4312 (MMP1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    4312 (MMP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4312 (MMP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.7  interstitial collagenase
     4312 (MMP1)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M10
   4312 (MMP1)
SSDB
Motif
Pfam: Peptidase_M10 Hemopexin PG_binding_1 Reprolysin_3 Reprolysin_5 DUF4953 Reprolysin_4 Peptidase_M54 Peptidase_M66 Metallopep FSAP_sig_propep
Other DBs
NCBI-GeneID: 4312
NCBI-ProteinID: NP_002412
OMIM: 120353
HGNC: 7155
Ensembl: ENSG00000196611
UniProt: P03956 Q53G95
Structure
Position
11:complement(102789919..102798160)
AA seq 469 aa
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
NT seq 1410 nt   +upstreamnt  +downstreamnt
atgcacagctttcctccactgctgctgctgctgttctggggtgtggtgtctcacagcttc
ccagcgactctagaaacacaagagcaagatgtggacttagtccagaaatacctggaaaaa
tactacaacctgaagaatgatgggaggcaagttgaaaagcggagaaatagtggcccagtg
gttgaaaaattgaagcaaatgcaggaattctttgggctgaaagtgactgggaaaccagat
gctgaaaccctgaaggtgatgaagcagcccagatgtggagtgcctgatgtggctcagttt
gtcctcactgaggggaaccctcgctgggagcaaacacatctgacctacaggattgaaaat
tacacgccagatttgccaagagcagatgtggaccatgccattgagaaagccttccaactc
tggagtaatgtcacacctctgacattcaccaaggtctctgagggtcaagcagacatcatg
atatcttttgtcaggggagatcatcgggacaactctccttttgatggacctggaggaaat
cttgctcatgcttttcaaccaggcccaggtattggaggggatgctcattttgatgaagat
gaaaggtggaccaacaatttcagagagtacaacttacatcgtgttgcagctcatgaactc
ggccattctcttggactctcccattctactgatatcggggctttgatgtaccctagctac
accttcagtggtgatgttcagctagctcaggatgacattgatggcatccaagccatatat
ggacgttcccaaaatcctgtccagcccatcggcccacaaaccccaaaagcgtgtgacagt
aagctaacctttgatgctataactacgattcggggagaagtgatgttctttaaagacaga
ttctacatgcgcacaaatcccttctacccggaagttgagctcaatttcatttctgttttc
tggccacaactgccaaatgggcttgaagctgcttacgaatttgccgacagagatgaagtc
cggtttttcaaagggaataagtactgggctgttcagggacagaatgtgctacacggatac
cccaaggacatctacagctcctttggcttccctagaactgtgaagcatatcgatgctgct
ctttctgaggaaaacactggaaaaacctacttctttgttgctaacaaatactggaggtat
gatgaatataaacgatctatggatccaggttatcccaaaatgatagcacatgactttcct
ggaattggccacaaagttgatgcagttttcatgaaagatggatttttctatttctttcat
ggaacaagacaatacaaatttgatcctaaaacgaagagaattttgactctccagaaagct
aatagctggttcaactgcaggaaaaattga

  All links  
Disease (1)   
   OMIM (1)   
Gene (16)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (44)   
   RefSeq(nuc) (2)   
   GenBank (21)   
   EMBL (21)   
3D Structure (15)   
   PDB (15)   
Protein domain (11)   
   Pfam (11)   
All databases (92)   

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