KEGG   Homo sapiens (human): 4317Help
Entry
4317              CDS       T01001                                 

Gene name
MMP8, CLG1, HNC, MMP-8, PMNL-CL
Definition
(RefSeq) matrix metallopeptidase 8
  KO
K01402  matrix metalloproteinase-8 (neutrophil collagenase) [EC:3.4.24.34]
Organism
hsa  Homo sapiens (human)
Drug target
Cipemastat: D03517
Rebimastat: D03800
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4317 (MMP8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.34  neutrophil collagenase
     4317 (MMP8)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M10
   4317 (MMP8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_M10 Hemopexin PG_binding_1 Reprolysin_3 Reprolysin_5 Reprolysin_4 DUF4953
Motif
Other DBs
NCBI-GeneID: 4317
NCBI-ProteinID: NP_002415
OMIM: 120355
HGNC: 7175
Ensembl: ENSG00000118113
Vega: OTTHUMG00000167587
Pharos: P22894(Tclin)
UniProt: P22894
Structure
PDB: 

Position
11q22.2
AA seq 467 aa AA seqDB search
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
NT seq 1404 nt NT seq  +upstreamnt  +downstreamnt
atgttctccctgaagacgcttccatttctgctcttactccatgtgcagatttccaaggcc
tttcctgtatcttctaaagagaaaaatacaaaaactgttcaggactacctggaaaagttc
taccaattaccaagcaaccagtatcagtctacaaggaagaatggcactaatgtgatcgtt
gaaaagcttaaagaaatgcagcgattttttgggttgaatgtgacggggaagccaaatgag
gaaactctggacatgatgaaaaagcctcgctgtggagtgcctgacagtggtggttttatg
ttaaccccaggaaaccccaagtgggaacgcactaacttgacctacaggattcgaaactat
accccacagctgtcagaggctgaggtagaaagagctatcaaggatgcctttgaactctgg
agtgttgcatcacctctcatcttcaccaggatctcacagggagaggcagatatcaacatt
gctttttaccaaagagatcacggtgacaattctccatttgatggacccaatggaatcctt
gctcatgcctttcagccaggccaaggtattggaggagatgctcattttgatgccgaagaa
acatggaccaacacctccgcaaattacaacttgtttcttgttgctgctcatgaatttggc
cattctttggggctcgctcactcctctgaccctggtgccttgatgtatcccaactatgct
ttcagggaaaccagcaactactcactccctcaagatgacatcgatggcattcaggccatc
tatggactttcaagcaaccctatccaacctactggaccaagcacacccaaaccctgtgac
cccagtttgacatttgatgctatcaccacactccgtggagaaatacttttctttaaagac
aggtacttctggagaaggcatcctcagctacaaagagtcgaaatgaattttatttctcta
ttctggccatcccttccaactggtatacaggctgcttatgaagattttgacagagacctc
attttcctatttaaaggcaaccaatactgggctctgagtggctatgatattctgcaaggt
tatcccaaggatatatcaaactatggcttccccagcagcgtccaagcaattgacgcagct
gttttctacagaagtaaaacatacttctttgtaaatgaccaattctggagatatgataac
caaagacaattcatggagccaggttatcccaaaagcatatcaggtgcctttccaggaata
gagagtaaagttgatgcagttttccagcaagaacatttcttccatgtcttcagtggacca
agatattacgcatttgatcttattgctcagagagttaccagagttgcaagaggcaataaa
tggcttaactgtagatatggctga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (33)   
   RefSeq(nuc) (7)   
   GenBank (13)   
   EMBL (13)   
Protein domain (7)   
   Pfam (7)   
All databases (67)   

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