KEGG   Homo sapiens (human): 4317Help
Entry
4317              CDS       T01001                                 

Gene name
MMP8, CLG1, HNC, MMP-8, PMNL-CL
Definition
(RefSeq) matrix metallopeptidase 8
  KO
K01402  matrix metalloproteinase-8 (neutrophil collagenase) [EC:3.4.24.34]
Organism
hsa  Homo sapiens (human)
Drug target
Cipemastat: D03517
Rebimastat: D03800
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4317 (MMP8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.34  neutrophil collagenase
     4317 (MMP8)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M10
   4317 (MMP8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_M10 Hemopexin PG_binding_1 Reprolysin_3 Reprolysin_5 Reprolysin_4 DUF4953
Motif
Other DBs
NCBI-GeneID: 4317
NCBI-ProteinID: NP_002415
OMIM: 120355
HGNC: 7175
Ensembl: ENSG00000118113
Vega: OTTHUMG00000167587
Pharos: P22894(Tclin)
UniProt: P22894
Structure
PDB: 

Position
11q22.2
AA seq 467 aa AA seqDB search
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
NT seq 1404 nt NT seq  +upstreamnt  +downstreamnt
atgttctccctgaagacgcttccatttctgctcttactccatgtgcagatttccaaggcc
tttcctgtatcttctaaagagaaaaatacaaaaactgttcaggactacctggaaaagttc
taccaattaccaagcaaccagtatcagtctacaaggaagaatggcactaatgtgatcgtt
gaaaagcttaaagaaatgcagcgattttttgggttgaatgtgacggggaagccaaatgag
gaaactctggacatgatgaaaaagcctcgctgtggagtgcctgacagtggtggttttatg
ttaaccccaggaaaccccaagtgggaacgcactaacttgacctacaggattcgaaactat
accccacagctgtcagaggctgaggtagaaagagctatcaaggatgcctttgaactctgg
agtgttgcatcacctctcatcttcaccaggatctcacagggagaggcagatatcaacatt
gctttttaccaaagagatcacggtgacaattctccatttgatggacccaatggaatcctt
gctcatgcctttcagccaggccaaggtattggaggagatgctcattttgatgccgaagaa
acatggaccaacacctccgcaaattacaacttgtttcttgttgctgctcatgaatttggc
cattctttggggctcgctcactcctctgaccctggtgccttgatgtatcccaactatgct
ttcagggaaaccagcaactactcactccctcaagatgacatcgatggcattcaggccatc
tatggactttcaagcaaccctatccaacctactggaccaagcacacccaaaccctgtgac
cccagtttgacatttgatgctatcaccacactccgtggagaaatacttttctttaaagac
aggtacttctggagaaggcatcctcagctacaaagagtcgaaatgaattttatttctcta
ttctggccatcccttccaactggtatacaggctgcttatgaagattttgacagagacctc
attttcctatttaaaggcaaccaatactgggctctgagtggctatgatattctgcaaggt
tatcccaaggatatatcaaactatggcttccccagcagcgtccaagcaattgacgcagct
gttttctacagaagtaaaacatacttctttgtaaatgaccaattctggagatatgataac
caaagacaattcatggagccaggttatcccaaaagcatatcaggtgcctttccaggaata
gagagtaaagttgatgcagttttccagcaagaacatttcttccatgtcttcagtggacca
agatattacgcatttgatcttattgctcagagagttaccagagttgcaagaggcaataaa
tggcttaactgtagatatggctga

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