KEGG   Homo sapiens (human): 4317
Entry
4317              CDS       T01001                                 
Symbol
MMP8, CLG1, HNC, MMP-8, PMNL-CL
Name
(RefSeq) matrix metallopeptidase 8
  KO
K01402  matrix metalloproteinase-8 (neutrophil collagenase) [EC:3.4.24.34]
Organism
hsa  Homo sapiens (human)
Drug target
Cipemastat: D03517
Rebimastat: D03800
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4317 (MMP8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.34  neutrophil collagenase
     4317 (MMP8)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M10
   4317 (MMP8)
SSDB
Motif
Pfam: Peptidase_M10 Hemopexin PG_binding_1 Reprolysin_3 Reprolysin_5 Reprolysin_4 DUF4953
Other DBs
NCBI-GeneID: 4317
NCBI-ProteinID: NP_002415
OMIM: 120355
HGNC: 7175
Ensembl: ENSG00000118113
UniProt: P22894
Structure
Position
11:complement(102711796..102724954)
AA seq 467 aa
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
NT seq 1404 nt   +upstreamnt  +downstreamnt
atgttctccctgaagacgcttccatttctgctcttactccatgtgcagatttccaaggcc
tttcctgtatcttctaaagagaaaaatacaaaaactgttcaggactacctggaaaagttc
taccaattaccaagcaaccagtatcagtctacaaggaagaatggcactaatgtgatcgtt
gaaaagcttaaagaaatgcagcgattttttgggttgaatgtgacggggaagccaaatgag
gaaactctggacatgatgaaaaagcctcgctgtggagtgcctgacagtggtggttttatg
ttaaccccaggaaaccccaagtgggaacgcactaacttgacctacaggattcgaaactat
accccacagctgtcagaggctgaggtagaaagagctatcaaggatgcctttgaactctgg
agtgttgcatcacctctcatcttcaccaggatctcacagggagaggcagatatcaacatt
gctttttaccaaagagatcacggtgacaattctccatttgatggacccaatggaatcctt
gctcatgcctttcagccaggccaaggtattggaggagatgctcattttgatgccgaagaa
acatggaccaacacctccgcaaattacaacttgtttcttgttgctgctcatgaatttggc
cattctttggggctcgctcactcctctgaccctggtgccttgatgtatcccaactatgct
ttcagggaaaccagcaactactcactccctcaagatgacatcgatggcattcaggccatc
tatggactttcaagcaaccctatccaacctactggaccaagcacacccaaaccctgtgac
cccagtttgacatttgatgctatcaccacactccgtggagaaatacttttctttaaagac
aggtacttctggagaaggcatcctcagctacaaagagtcgaaatgaattttatttctcta
ttctggccatcccttccaactggtatacaggctgcttatgaagattttgacagagacctc
attttcctatttaaaggcaaccaatactgggctctgagtggctatgatattctgcaaggt
tatcccaaggatatatcaaactatggcttccccagcagcgtccaagcaattgacgcagct
gttttctacagaagtaaaacatacttctttgtaaatgaccaattctggagatatgataac
caaagacaattcatggagccaggttatcccaaaagcatatcaggtgcctttccaggaata
gagagtaaagttgatgcagttttccagcaagaacatttcttccatgtcttcagtggacca
agatattacgcatttgatcttattgctcagagagttaccagagttgcaagaggcaataaa
tggcttaactgtagatatggctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (7)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (37)   
   RefSeq(nuc) (11)   
   GenBank (13)   
   EMBL (13)   
3D Structure (25)   
   PDB (25)   
Protein domain (7)   
   Pfam (7)   
All databases (90)   

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