KEGG   Homo sapiens (human): 4361
Entry
4361              CDS       T01001                                 
Symbol
MRE11, ATLD, HNGS1, MRE11A, MRE11B
Name
(RefSeq) MRE11 double strand break repair nuclease
  KO
K10865  double-strand break repair protein MRE11
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03450  Non-homologous end-joining
hsa04218  Cellular senescence
Network
nt06506  Double-strand break repair
  Element
N01439  Double-strand break signaling
N01446  DNA end resection and RPA loading
Disease
H00094  Immunodeficiency associated with DNA repair defects
H02014  Ataxia-telangiectasia-like syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    4361 (MRE11)
   03450 Non-homologous end-joining
    4361 (MRE11)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    4361 (MRE11)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4361 (MRE11)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    4361 (MRE11)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   MRN complex
    4361 (MRE11)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    MRN(MRX) complex
     4361 (MRE11)
    BRCA1-C complex
     4361 (MRE11)
   NHEJ (non-homologous end-joining)
    MRX complex
     4361 (MRE11)
SSDB
Motif
Pfam: Mre11_DNA_bind Metallophos
Other DBs
NCBI-GeneID: 4361
NCBI-ProteinID: NP_005582
OMIM: 600814
HGNC: 7230
Ensembl: ENSG00000020922
UniProt: P49959
Structure
Position
11:complement(94415570..94512412)
AA seq 708 aa
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD
LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI
PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG
LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL
VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP
LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK
PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK
PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK
TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF
SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE
TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS
KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
NT seq 2127 nt   +upstreamnt  +downstreamnt
atgagtactgcagatgcacttgatgatgaaaacacatttaaaatattagttgcaacagat
attcatcttggatttatggagaaagatgcagtcagaggaaatgatacgtttgtaacactc
gatgaaattttaagacttgcccaggaaaatgaagtggattttattttgttaggtggtgat
ctttttcatgaaaataagccctcaaggaaaacattacatacctgcctcgagttattaaga
aaatattgtatgggtgatcggcctgtccagtttgaaattctcagtgatcagtcagtcaac
tttggttttagtaagtttccatgggtgaactatcaagatggcaacctcaacatttcaatt
ccagtgtttagtattcatggcaatcatgacgatcccacaggggcagatgcactttgtgcc
ttggacattttaagttgtgctggatttgtaaatcactttggacgttcaatgtctgtggag
aagatagacattagtccggttttgcttcaaaaaggaagcacaaagattgcgctatatggt
ttaggatccattccagatgaaaggctctatcgaatgtttgtcaataaaaaagtaacaatg
ttgagaccaaaggaagatgagaactcttggtttaacttatttgtgattcatcagaacagg
agtaaacatggaagtactaacttcattccagaacaatttttggatgacttcattgatctt
gttatctggggccatgaacatgagtgtaaaatagctccaaccaaaaatgaacaacagctg
ttttatatctcacaacctggaagctcagtggttacttctctttccccaggagaagctgta
aagaaacatgttggtttgctgcgtattaaagggaggaagatgaatatgcataaaattcct
cttcacacagtgcggcagtttttcatggaggatattgttctagctaatcatccagacatt
tttaacccagataatcctaaagtaacccaagccatacaaagcttctgtttggagaagatt
gaagaaatgcttgaaaatgctgaacgggaacgtctgggtaattctcaccagccagagaag
cctcttgtacgactgcgagtggactatagtggaggttttgaacctttcagtgttcttcgc
tttagccagaaatttgtggatcgggtagctaatccaaaagacattatccattttttcagg
catagagaacaaaaggaaaaaacaggagaagagatcaactttgggaaacttatcacaaag
ccttcagaaggaacaactttaagggtagaagatcttgtaaaacagtactttcaaaccgca
gagaagaatgtgcagctctcactgctaacagaaagagggatgggtgaagcagtacaagaa
tttgtggacaaggaggagaaagatgccattgaggaattagtgaaataccagttggaaaaa
acacagcgatttcttaaagaacgtcatattgatgccctcgaagacaaaatcgatgaggag
gtacgtcgtttcagagaaaccagacaaaaaaatactaatgaagaagatgatgaagtccgt
gaggctatgaccagggccagagcactcagatctcagtcagaggagtctgcttctgccttt
agtgctgatgaccttatgagtatagatttagcagaacagatggctaatgactctgatgat
agcatctcagcagcaaccaacaaaggaagaggccgaggaagaggtcgaagaggtggaaga
gggcagaattcagcatcgagaggagggtctcaaagaggaagagcagacactggtctggag
acttctacccgtagcaggaactcaaagactgctgtgtcagcatctagaaatatgtctatt
atagatgcctttaaatctacaagacagcagccttcccgaaatgtcactactaagaattat
tcagaggtgattgaggtagatgaatcagatgtggaagaagacatttttcctaccacttca
aagacagatcaaaggtggtccagcacatcatccagcaaaatcatgtcccagagtcaagta
tcgaaaggggttgattttgaatcaagtgaggatgatgatgatgatccttttatgaacact
agttctttaagaagaaatagaagataa

  All links  
Disease (2)   
   OMIM (2)   
Gene (23)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (37)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (35)   
DNA sequence (65)   
   RefSeq(nuc) (39)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (133)   

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