KEGG   Homo sapiens (human): 4436Help
Entry
4436              CDS       T01001                                 

Gene name
MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, hMSH2
Definition
(RefSeq) mutS homolog 2
  KO
K08735  DNA mismatch repair protein MSH2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa03430  Mismatch repair
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
Module
hsa_M00295  BRCA1-associated genome surveillance complex (BASC)
Disease
H00020  Colorectal cancer
H00027  Ovarian cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    4436 (MSH2)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    4436 (MSH2)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    4436 (MSH2)
  09176 Drug resistance: Antineoplastic
   01524 Platinum drug resistance
    4436 (MSH2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    4436 (MSH2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     4436 (MSH2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: MutS_V MutS_III MutS_II MutS_I MutS_IV AAA_27 ArdA
Motif
Other DBs
NCBI-GeneID: 4436
NCBI-ProteinID: NP_000242
OMIM: 609309
HGNC: 7325
Ensembl: ENSG00000095002
Vega: OTTHUMG00000128861
Pharos: P43246(Tbio)
UniProt: P43246
Structure
PDB: 

Position
2p21-p16.3
AA seq 934 aa AA seqDB search
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKT
QGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLA
YKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD
LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYM
KLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA
LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE
LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFS
TVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLA
QLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKD
KQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLK
GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMF
ATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV
IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMS
EENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
NT seq 2805 nt NT seq  +upstreamnt  +downstreamnt
atggcggtgcagccgaaggagacgctgcagttggagagcgcggccgaggtcggcttcgtg
cgcttctttcagggcatgccggagaagccgaccaccacagtgcgccttttcgaccggggc
gacttctatacggcgcacggcgaggacgcgctgctggccgcccgggaggtgttcaagacc
cagggggtgatcaagtacatggggccggcaggagcaaagaatctgcagagtgttgtgctt
agtaaaatgaattttgaatcttttgtaaaagatcttcttctggttcgtcagtatagagtt
gaagtttataagaatagagctggaaataaggcatccaaggagaatgattggtatttggca
tataaggcttctcctggcaatctctctcagtttgaagacattctctttggtaacaatgat
atgtcagcttccattggtgttgtgggtgttaaaatgtccgcagttgatggccagagacag
gttggagttgggtatgtggattccatacagaggaaactaggactgtgtgaattccctgat
aatgatcagttctccaatcttgaggctctcctcatccagattggaccaaaggaatgtgtt
ttacccggaggagagactgctggagacatggggaaactgagacagataattcaaagagga
ggaattctgatcacagaaagaaaaaaagctgacttttccacaaaagacatttatcaggac
ctcaaccggttgttgaaaggcaaaaagggagagcagatgaatagtgctgtattgccagaa
atggagaatcaggttgcagtttcatcactgtctgcggtaatcaagtttttagaactctta
tcagatgattccaactttggacagtttgaactgactacttttgacttcagccagtatatg
aaattggatattgcagcagtcagagcccttaacctttttcagggttctgttgaagatacc
actggctctcagtctctggctgccttgctgaataagtgtaaaacccctcaaggacaaaga
cttgttaaccagtggattaagcagcctctcatggataagaacagaatagaggagagattg
aatttagtggaagcttttgtagaagatgcagaattgaggcagactttacaagaagattta
cttcgtcgattcccagatcttaaccgacttgccaagaagtttcaaagacaagcagcaaac
ttacaagattgttaccgactctatcagggtataaatcaactacctaatgttatacaggct
ctggaaaaacatgaaggaaaacaccagaaattattgttggcagtttttgtgactcctctt
actgatcttcgttctgacttctccaagtttcaggaaatgatagaaacaactttagatatg
gatcaggtggaaaaccatgaattccttgtaaaaccttcatttgatcctaatctcagtgaa
ttaagagaaataatgaatgacttggaaaagaagatgcagtcaacattaataagtgcagcc
agagatcttggcttggaccctggcaaacagattaaactggattccagtgcacagtttgga
tattactttcgtgtaacctgtaaggaagaaaaagtccttcgtaacaataaaaactttagt
actgtagatatccagaagaatggtgttaaatttaccaacagcaaattgacttctttaaat
gaagagtataccaaaaataaaacagaatatgaagaagcccaggatgccattgttaaagaa
attgtcaatatttcttcaggctatgtagaaccaatgcagacactcaatgatgtgttagct
cagctagatgctgttgtcagctttgctcacgtgtcaaatggagcacctgttccatatgta
cgaccagccattttggagaaaggacaaggaagaattatattaaaagcatccaggcatgct
tgtgttgaagttcaagatgaaattgcatttattcctaatgacgtatactttgaaaaagat
aaacagatgttccacatcattactggccccaatatgggaggtaaatcaacatatattcga
caaactggggtgatagtactcatggcccaaattgggtgttttgtgccatgtgagtcagca
gaagtgtccattgtggactgcatcttagcccgagtaggggctggtgacagtcaattgaaa
ggagtctccacgttcatggctgaaatgttggaaactgcttctatcctcaggtctgcaacc
aaagattcattaataatcatagatgaattgggaagaggaacttctacctacgatggattt
gggttagcatgggctatatcagaatacattgcaacaaagattggtgctttttgcatgttt
gcaacccattttcatgaacttactgccttggccaatcagataccaactgttaataatcta
catgtcacagcactcaccactgaagagaccttaactatgctttatcaggtgaagaaaggt
gtctgtgatcaaagttttgggattcatgttgcagagcttgctaatttccctaagcatgta
atagagtgtgctaaacagaaagccctggaacttgaggagtttcagtatattggagaatcg
caaggatatgatatcatggaaccagcagcaaagaagtgctatctggaaagagagcaaggt
gaaaaaattattcaggagttcctgtccaaggtgaaacaaatgccctttactgaaatgtca
gaagaaaacatcacaataaagttaaaacagctaaaagctgaagtaatagcaaagaataat
agctttgtaaatgaaatcatttcacgaataaaagttactacgtga

DBGET integrated database retrieval system