KEGG   Homo sapiens (human): 4486
Entry
4486              CDS       T01001                                 
Symbol
MST1R, CD136, CDw136, NPCA3, PTK8, RON, SEA, p185-Ron
Name
(RefSeq) macrophage stimulating 1 receptor
  KO
K05100  macrophage-stimulating 1 receptor [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
Network
nt06528  Calcium signaling
  Element
N01641  RTK-PLCG-ITPR signaling pathway
Disease
H00054  Nasopharyngeal cancer
Drug target
Merestinib: D11763
Narnatumab: D10074
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    4486 (MST1R)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4486 (MST1R)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    4486 (MST1R)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     4486 (MST1R)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  MET family
   4486 (MST1R)
CD molecules [BR:hsa04090]
 Proteins
  4486 (MST1R)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase TIG Sema PSI Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 4486
NCBI-ProteinID: NP_002438
OMIM: 600168
HGNC: 7381
Ensembl: ENSG00000164078
UniProt: Q04912
Structure
Position
3:complement(49887002..49903873)
AA seq 1400 aa
MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVT
YEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDT
KVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVAS
PLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPK
HLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDC
RFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGV
GPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNT
SCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSL
NYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAW
HFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSG
LVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVT
NMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVN
GTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCG
YINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAG
NLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTV
GGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLG
ILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSG
LALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERV
VTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNH
PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA
EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQ
TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM
QQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQF
SPMPGNVRRPRPLSEPPRPT
NT seq 4203 nt   +upstreamnt  +downstreamnt
atggagctcctcccgccgctgcctcagtccttcctgttgctgctgctgttgcctgccaag
cccgcggcgggcgaggactggcagtgcccgcgcaccccctacgcggcctctcgcgacttt
gacgtgaagtacgtggtgcccagcttctccgccggaggcctggtacaggccatggtgacc
tacgagggcgacagaaatgagagtgctgtgtttgtagccatacgcaatcgcctgcatgtg
cttgggcctgacctgaagtctgtccagagcctggccacgggccctgctggagaccctggc
tgccagacgtgtgcagcctgtggcccaggaccccacggccctcccggtgacacagacaca
aaggtgctggtgctggatcccgcgctgcctgcgctggtcagttgtggctccagcctgcag
ggccgctgcttcctgcatgacctagagccccaagggacagccgtgcatctggcagcgcca
gcctgcctcttctcagcccaccataaccggcccgatgactgccccgactgtgtggccagc
ccattgggcacccgtgtaactgtggttgagcaaggccaggcctcctatttctacgtggca
tcctcactggacgcagccgtggctgccagcttcagcccacgctcagtgtctatcaggcgt
ctcaaggctgacgcctcgggattcgcaccgggctttgtggcgttgtcagtgctgcccaag
catcttgtctcctacagtattgaatacgtgcacagcttccacacgggagccttcgtatac
ttcctgactgtacagccggccagcgtgacagatgatcctagtgccctgcacacacgcctg
gcacggcttagcgccactgagccagagttgggtgactatcgggagctggtcctcgactgc
agatttgctccaaaacgcaggcgccggggggccccagaaggcggacagccctaccctgtg
ctgcgggtggcccactccgctccagtgggtgcccaacttgccactgagctgagcatcgcc
gagggccaggaagtactatttggggtctttgtgactggcaaggatggtggtcctggcgtg
ggccccaactctgtcgtctgtgccttccccattgacctgctggacacactaattgatgag
ggtgtggagcgctgttgtgaatccccagtccatccaggcctccggcgaggcctcgacttc
ttccagtcgcccagtttttgccccaacccgcctggcctggaagccctcagccccaacacc
agctgccgccacttccctctgctggtcagtagcagcttctcacgtgtggacctattcaat
gggctgttgggaccagtacaggtcactgcattgtatgtgacacgccttgacaacgtcaca
gtggcacacatgggcacaatggatgggcgtatcctgcaggtggagctggtcaggtcacta
aactacttgctgtatgtgtccaacttctcactgggtgacagtgggcagcccgtgcagcgg
gatgtcagtcgtcttggggaccacctactctttgcctctggggaccaggttttccaggta
cctatccaaggccctggctgccgccacttcctgacctgtgggcgttgcctaagggcatgg
catttcatgggctgtggctggtgtgggaacatgtgcggccagcagaaggagtgtcctggc
tcctggcaacaggaccactgcccacctaagcttactgagttccacccccacagtggacct
ctaaggggcagtacaaggctgaccctgtgtggctccaacttctaccttcacccttctggt
ctggtgcctgagggaacccatcaggtcactgtgggccaaagtccctgccggccactgccc
aaggacagctcaaaactcagaccagtgccccggaaagactttgtagaggagtttgagtgt
gaactggagcccttgggcacccaggcagtggggcctaccaacgtcagcctcaccgtgact
aacatgccaccgggcaagcacttccgggtagacggcacctccgtgctgagaggcttctct
ttcatggagccagtgctgatagcagtgcaacccctctttggcccacgggcaggaggcacc
tgtctcactcttgaaggccagagtctgtctgtaggcaccagccgggctgtgctggtcaat
gggactgagtgtctgctagcacgggtcagtgaggggcagcttttatgtgccacaccccct
ggggccacggtggccagtgtcccccttagcctgcaggtggggggtgcccaggtacctggt
tcctggaccttccagtacagagaagaccctgtcgtgctaagcatcagccccaactgtggc
tacatcaactcccacatcaccatctgtggccagcatctaacttcagcatggcacttagtg
ctgtcattccatgacgggcttagggcagtggaaagcaggtgtgagaggcagcttccagag
cagcagctgtgccgccttcctgaatatgtggtccgagacccccagggatgggtggcaggg
aatctgagtgcccgaggggatggagctgctggctttacactgcctggctttcgcttccta
cccccaccccatccacccagtgccaacctagttccactgaagcctgaggagcatgccatt
aagtttgagtatattgggctgggcgctgtggctgactgtgtgggtatcaacgtgaccgtg
ggtggtgagagctgccagcacgagttccggggggacatggttgtctgccccctgccccca
tccctgcagcttggccaggatggtgccccattgcaggtctgcgtagatggtgaatgtcat
atcctgggtagagtggtgcggccagggccagatggggtcccacagagcacgctccttggt
atcctgctgcctttgctgctgcttgtggctgcactggcgactgcactggtcttcagctac
tggtggcggaggaagcagctagttcttcctcccaacctgaatgacctggcatccctggac
cagactgctggagccacacccctgcctattctgtactcgggctctgactacagaagtggc
cttgcactccctgccattgatggtctggattccaccacttgtgtccatggagcatccttc
tccgatagtgaagatgaatcctgtgtgccactgctgcggaaagagtccatccagctaagg
gacctggactctgcgctcttggctgaggtcaaggatgtgctgattccccatgagcgggtg
gtcacccacagtgaccgagtcattggcaaaggccactttggagttgtctaccacggagaa
tacatagaccaggcccagaatcgaatccaatgtgccatcaagtcactaagtcgcatcaca
gagatgcagcaggtggaggccttcctgcgagaggggctgctcatgcgtggcctgaaccac
ccgaatgtgctggctctcattggtatcatgttgccacctgagggcctgccccatgtgctg
ctgccctatatgtgccacggtgacctgctccagttcatccgctcacctcagcggaacccc
accgtgaaggacctcatcagctttggcctgcaggtagcccgcggcatggagtacctggca
gagcagaagtttgtgcacagggacctggctgcgcggaactgcatgctggacgagtcattc
acagtcaaggtggctgactttggtttggcccgcgacatcctggacagggagtactatagt
gttcaacagcatcgccacgctcgcctacctgtgaagtggatggcgctggagagcctgcag
acctatagatttaccaccaagtctgatgtgtggtcatttggtgtgctgctgtgggaactg
ctgacacggggtgccccaccataccgccacattgacccttttgaccttacccacttcctg
gcccagggtcggcgcctgccccagcctgagtattgccctgattctctgtaccaagtgatg
cagcaatgctgggaggcagacccagcagtgcgacccaccttcagagtactagtgggggag
gtggagcagatagtgtctgcactgcttggggaccattatgtgcagctgccagcaacctac
atgaacttgggccccagcacctcgcatgagatgaatgtgcgtccagaacagccgcagttc
tcacccatgccagggaatgtacgccggccccggccactctcagagcctcctcggcccact
tga

  All links  
Disease (2)   
   OMIM (2)   
Gene (33)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (58)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (56)   
DNA sequence (87)   
   RefSeq(nuc) (59)   
   GenBank (14)   
   EMBL (14)   
3D Structure (4)   
   PDB (4)   
Protein domain (7)   
   Pfam (7)   
All databases (191)   

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