KEGG   Homo sapiens (human): 4537Help
Entry
4537              CDS       T01001                                 

Gene name
ND3, MTND3, MT-ND3
Definition
(RefSeq) NADH dehydrogenase, subunit 3 (complex I)
  KO
K03880  NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04714  Thermogenesis
hsa04723  Retrograde endocannabinoid signaling
hsa05012  Parkinson disease
Module
hsa_M00142  NADH:ubiquinone oxidoreductase, mitochondria
Disease
H00473  Mitochondrial complex I deficiency
H01355  Kearns-Sayre syndrome
H01365  Leber hereditary optic neuropathy and dystonia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4537 (ND3)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    4537 (ND3)
  09159 Environmental adaptation
   04714 Thermogenesis
    4537 (ND3)
 09160 Human Diseases
  09164 Neurodegenerative diseases
   05012 Parkinson disease
    4537 (ND3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4537 (ND3)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of hydrons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     4537 (ND3)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    4537 (ND3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Oxidored_q4 SHP
Motif
Other DBs
NCBI-GeneID: 4537
NCBI-ProteinID: YP_003024033
OMIM: 516002
HGNC: 7458
Pharos: P03897(Tclin)
UniProt: P03897 Q7GXZ5
Structure
PDB: 

Position
MT
AA seq 115 aa AA seqDB search
MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAI
TFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWTE
NT seq 346 nt NT seq  +upstreamnt  +downstreamnt
ataaacttcgccttaattttaataatcaacaccctcctagccttactactaataattatt
acattttgactaccacaactcaacggctacatagaaaaatccaccccttacgagtgcggc
ttcgaccctatatcccccgcccgcgtccctttctccataaaattcttcttagtagctatt
accttcttattatttgatctagaaattgccctccttttacccctaccatgagccctacaa
acaactaacctgccactaatagttatgtcatccctcttattaatcatcatcctagcccta
agtctggcctatgagtgactacaaaaaggattagactgaaccgaat

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