KEGG   Homo sapiens (human): 4543
Entry
4543              CDS       T01001                                 

Gene name
MTNR1A, MEL-1A-R, MT1
Definition
(RefSeq) melatonin receptor 1A
  KO
K04285  melatonin receptor type 1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Drug target
Agomelatine: D02578
Melatonin: D08170<JP>
Ramelteon: D02689<JP/US>
Tasimelteon: D09388<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4543 (MTNR1A)
 09150 Organismal Systems
  09159 Environmental adaptation
   04713 Circadian entrainment
    4543 (MTNR1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4543 (MTNR1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Melatonin
    4543 (MTNR1A)
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx 7tm_4 TctB
Other DBs
NCBI-GeneID: 4543
NCBI-ProteinID: NP_005949
OMIM: 600665
HGNC: 7463
Ensembl: ENSG00000168412
Vega: OTTHUMG00000185575
Pharos: P48039(Tclin)
UniProt: P48039
Position
4q35.2
AA seq 350 aa
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgcagggcaacggcagcgcgctgcccaacgcctcccagcccgtgctccgcggggacggc
gcgcggccctcgtggctggcgtccgccctggcctgcgtcctcatcttcaccatcgtggtg
gacatcctgggcaacctcctggtcatcctgtcggtgtatcggaacaagaagctcaggaac
gcaggaaacatctttgtggtgagcttagcggtggcagacctggtggtggccatttatccg
tacccgttggtgctgatgtcgatatttaacaacgggtggaacctgggctatctgcactgc
caagtcagtgggttcctgatgggcctgagcgtcatcggctccatattcaacatcaccggc
atcgccatcaaccgctactgctacatctgccacagtctcaagtacgacaaactgtacagc
agcaagaactccctctgctacgtgctcctcatatggctcctgacgctggcggccgtcctg
cccaacctccgtgcagggactctccagtacgacccgaggatctactcgtgcaccttcgcc
cagtccgtcagctccgcctacaccatcgccgtggtggttttccacttcctcgtccccatg
atcatagtcatcttctgttacctgagaatatggatcctggttctccaggtcagacagagg
gtgaaacctgaccgcaaacccaaactgaaaccacaggacttcaggaattttgtcaccatg
tttgtggtttttgtcctttttgccatttgctgggctcctctgaacttcattggcctggcc
gtggcctctgaccccgccagcatggtgcctaggatcccagagtggctgtttgtggccagt
tactacatggcgtatttcaacagctgcctcaatgccattatatacgggctactgaaccaa
aatttcaggaaggaatacaggagaattatagtctcgctctgtacagccagggtgttcttt
gtggacagctctaacgacgtggccgatagggttaaatggaaaccgtctccactgatgacc
aacaataatgtagtaaaggtggactccgtttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (4)   
   KEGG DRUG (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
Protein domain (5)   
   Pfam (5)   
All databases (46)   

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