KEGG   Homo sapiens (human): 4543Help
Entry
4543              CDS       T01001                                 

Gene name
MTNR1A, MEL-1A-R, MT1
Definition
(RefSeq) melatonin receptor 1A
  KO
K04285  melatonin receptor type 1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Drug target
Agomelatine: D02578
Melatonin: D08170
Ramelteon: D02689
Tasimelteon: D09388
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4543 (MTNR1A)
 09150 Organismal Systems
  09159 Environmental adaptation
   04713 Circadian entrainment
    4543 (MTNR1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4543 (MTNR1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Melatonin
    4543 (MTNR1A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx 7tm_4 TctB
Motif
Other DBs
NCBI-GeneID: 4543
NCBI-ProteinID: NP_005949
OMIM: 600665
HGNC: 7463
Ensembl: ENSG00000168412
Vega: OTTHUMG00000185575
Pharos: P48039(Tclin)
UniProt: P48039
Position
4q35.2
AA seq 350 aa AA seqDB search
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
NT seq 1053 nt NT seq  +upstreamnt  +downstreamnt
atgcagggcaacggcagcgcgctgcccaacgcctcccagcccgtgctccgcggggacggc
gcgcggccctcgtggctggcgtccgccctggcctgcgtcctcatcttcaccatcgtggtg
gacatcctgggcaacctcctggtcatcctgtcggtgtatcggaacaagaagctcaggaac
gcaggaaacatctttgtggtgagcttagcggtggcagacctggtggtggccatttatccg
tacccgttggtgctgatgtcgatatttaacaacgggtggaacctgggctatctgcactgc
caagtcagtgggttcctgatgggcctgagcgtcatcggctccatattcaacatcaccggc
atcgccatcaaccgctactgctacatctgccacagtctcaagtacgacaaactgtacagc
agcaagaactccctctgctacgtgctcctcatatggctcctgacgctggcggccgtcctg
cccaacctccgtgcagggactctccagtacgacccgaggatctactcgtgcaccttcgcc
cagtccgtcagctccgcctacaccatcgccgtggtggttttccacttcctcgtccccatg
atcatagtcatcttctgttacctgagaatatggatcctggttctccaggtcagacagagg
gtgaaacctgaccgcaaacccaaactgaaaccacaggacttcaggaattttgtcaccatg
tttgtggtttttgtcctttttgccatttgctgggctcctctgaacttcattggcctggcc
gtggcctctgaccccgccagcatggtgcctaggatcccagagtggctgtttgtggccagt
tactacatggcgtatttcaacagctgcctcaatgccattatatacgggctactgaaccaa
aatttcaggaaggaatacaggagaattatagtctcgctctgtacagccagggtgttcttt
gtggacagctctaacgacgtggccgatagggttaaatggaaaccgtctccactgatgacc
aacaataatgtagtaaaggtggactccgtttaa

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