KEGG   Homo sapiens (human): 4544
Entry
4544              CDS       T01001                                 
Symbol
MTNR1B, FGQTL2, MEL-1B-R, MT2
Name
(RefSeq) melatonin receptor 1B
  KO
K04286  melatonin receptor type 1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Disease
H00409  Type 2 diabetes mellitus
Drug target
Agomelatine: D02578
Melatonin: D08170<JP>
Ramelteon: D02689<JP/US>
Tasimelteon: D09388<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4544 (MTNR1B)
 09150 Organismal Systems
  09159 Environmental adaptation
   04713 Circadian entrainment
    4544 (MTNR1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4544 (MTNR1B)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Melatonin
    4544 (MTNR1B)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4
Other DBs
NCBI-GeneID: 4544
NCBI-ProteinID: NP_005950
OMIM: 600804
HGNC: 7464
Ensembl: ENSG00000134640
UniProt: P49286
Structure
Position
11:92969651..92984960
AA seq 362 aa
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
NT seq 1089 nt   +upstreamnt  +downstreamnt
atgtcagagaacggctccttcgccaactgctgcgaggcgggcgggtgggcagtgcgcccg
ggctggtcgggggctggcagcgcgcggccctccaggacccctcgacctccctgggtggct
ccagcgctgtccgcggtgctcatcgtcaccaccgccgtggacgtcgtgggcaacctcctg
gtgatcctctccgtgctcaggaaccgcaagctccggaacgcaggtaatttgttcttggtg
agtctggcattggctgacctggtggtggccttctacccctacccgctaatcctcgtggcc
atcttctatgacggctgggccctgggggaggagcactgcaaggccagcgcctttgtgatg
ggcctgagcgtcatcggctctgtcttcaatatcactgccatcgccattaaccgctactgc
tacatctgccacagcatggcctaccaccgaatctaccggcgctggcacacccctctgcac
atctgcctcatctggctcctcaccgtggtggccttgctgcccaacttctttgtggggtcc
ctggagtacgacccacgcatctattcctgcaccttcatccagaccgccagcacccagtac
acggcggcagtggtggtcatccacttcctcctccctatcgctgtcgtgtccttctgctac
ctgcgcatctgggtgctggtgcttcaggcccgcaggaaagccaagccagagagcaggctg
tgcctgaagcccagcgacttgcggagctttctaaccatgtttgtggtgtttgtgatcttt
gccatctgctgggctccacttaactgcatcggcctcgctgtggccatcaacccccaagaa
atggctccccagatccctgaggggctatttgtcactagctacttactggcttatttcaac
agctgcctgaatgccattgtctatgggctcttgaaccaaaacttccgcagggaatacaag
aggatcctcttggccctttggaacccacggcactgcattcaagatgcttccaagggcagc
cacgcggaggggctgcagagcccagctccacccatcattggtgtgcagcaccaggcagat
gctctctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (20)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (15)   
   RefSeq(nuc) (5)   
   GenBank (5)   
   EMBL (5)   
3D Structure (5)   
   PDB (5)   
Protein domain (5)   
   Pfam (5)   
All databases (54)   

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