KEGG   Homo sapiens (human): 4544Help
Entry
4544              CDS       T01001                                 

Gene name
MTNR1B, FGQTL2, MEL-1B-R, MT2
Definition
(RefSeq) melatonin receptor 1B
  KO
K04286  melatonin receptor type 1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04713  Circadian entrainment
Disease
H00409  Type II diabetes mellitus
Drug target
Agomelatine: D02578
Melatonin: D08170
Ramelteon: D02689
Tasimelteon: D09388
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4544 (MTNR1B)
 09150 Organismal Systems
  09159 Environmental adaptation
   04713 Circadian entrainment
    4544 (MTNR1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4544 (MTNR1B)
G protein-coupled receptors [BR:hsa04030]
 Class A. Rhodopsin family
  Pineal gland hormone
   Melatonin
    4544 (MTNR1B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 4544
NCBI-ProteinID: NP_005950
OMIM: 600804
HGNC: 7464
Ensembl: ENSG00000134640
Vega: OTTHUMG00000167364
Pharos: P49286(Tclin)
UniProt: P49286
Position
11q14.3
AA seq 362 aa AA seqDB search
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
NT seq 1089 nt NT seq  +upstreamnt  +downstreamnt
atgtcagagaacggctccttcgccaactgctgcgaggcgggcgggtgggcagtgcgcccg
ggctggtcgggggctggcagcgcgcggccctccaggacccctcgacctccctgggtggct
ccagcgctgtccgcggtgctcatcgtcaccaccgccgtggacgtcgtgggcaacctcctg
gtgatcctctccgtgctcaggaaccgcaagctccggaacgcaggtaatttgttcttggtg
agtctggcattggctgacctggtggtggccttctacccctacccgctaatcctcgtggcc
atcttctatgacggctgggccctgggggaggagcactgcaaggccagcgcctttgtgatg
ggcctgagcgtcatcggctctgtcttcaatatcactgccatcgccattaaccgctactgc
tacatctgccacagcatggcctaccaccgaatctaccggcgctggcacacccctctgcac
atctgcctcatctggctcctcaccgtggtggccttgctgcccaacttctttgtggggtcc
ctggagtacgacccacgcatctattcctgcaccttcatccagaccgccagcacccagtac
acggcggcagtggtggtcatccacttcctcctccctatcgctgtcgtgtccttctgctac
ctgcgcatctgggtgctggtgcttcaggcccgcaggaaagccaagccagagagcaggctg
tgcctgaagcccagcgacttgcggagctttctaaccatgtttgtggtgtttgtgatcttt
gccatctgctgggctccacttaactgcatcggcctcgctgtggccatcaacccccaagaa
atggctccccagatccctgaggggctatttgtcactagctacttactggcttatttcaac
agctgcctgaatgccattgtctatgggctcttgaaccaaaacttccgcagggaatacaag
aggatcctcttggccctttggaacccacggcactgcattcaagatgcttccaagggcagc
cacgcggaggggctgcagagcccagctccacccatcattggtgtgcagcaccaggcagat
gctctctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (4)   
   KEGG DRUG (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (13)   
   RefSeq(nuc) (3)   
   GenBank (5)   
   EMBL (5)   
Protein domain (4)   
   Pfam (4)   
All databases (59)   

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