KEGG   Homo sapiens (human): 4547
Entry
4547              CDS       T01001                                 

Gene name
MTTP, ABL, MTP
Definition
(RefSeq) microsomal triglyceride transfer protein
  KO
K14463  microsomal triglyceride transfer protein large subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa04975  Fat digestion and absorption
Disease
H00160  Abetalipoproteinemia
Drug target
Lomitapide (DG00362): D09637 D09638<JP/US>
Mitratapide: D05060
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    4547 (MTTP)
SSDB
Motif
Pfam: MTP_lip_bd Vitellogenin_N DUF6018
Other DBs
NCBI-GeneID: 4547
NCBI-ProteinID: NP_000244
OMIM: 157147
HGNC: 7467
Ensembl: ENSG00000138823
Vega: OTTHUMG00000131023
Pharos: P55157(Tclin)
UniProt: P55157
Structure
PDB: 
6I7S

Position
4q23
AA seq 894 aa
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
NT seq 2685 nt   +upstreamnt  +downstreamnt
atgattcttcttgctgtgctttttctctgcttcatttcctcatattcagcttctgttaaa
ggtcacacaactggtctctcattaaataatgaccggctgtacaagctcacgtactccact
gaagttcttcttgatcggggcaaaggaaaactgcaagacagcgtgggctaccgcatttcc
tccaacgtggatgtggccttactatggaggaatcctgatggtgatgatgaccagttgatc
caaataacgatgaaggatgtaaatgttgaaaatgtgaatcagcagagaggagagaagagc
atcttcaaaggaaaaagcccatctaaaataatgggaaaggaaaacttggaagctctgcaa
agacctacgctccttcatctaatccatggaaaggtcaaagagttctactcatatcaaaat
gaggcagtggccatagaaaatatcaagagaggtctggctagcctatttcagacacagtta
agctctggaaccaccaatgaggtagatatctctggaaattgtaaagtgacctaccaggct
catcaagacaaagtgatcaaaattaaggccttggattcatgcaaaatagcgaggtctgga
tttacgaccccaaatcaggtcttgggtgtcagttcaaaagctacatctgtcaccacctat
aagatagaagacagctttgttatagctgtgcttgctgaagaaacacacaattttggactg
aatttcctacaaaccattaaggggaaaatagtatcgaagcagaaattagagctgaagaca
accgaagcaggcccaagattgatgtctggaaagcaggctgcagccataatcaaagcagtt
gattcaaagtacacggccattcccattgtggggcaggtcttccagagccactgtaaagga
tgtccttctctctcggagctctggcggtccaccaggaaatacctgcagcctgacaacctt
tccaaggctgaggctgtcagaaacttcctggccttcattcagcacctcaggactgcgaag
aaagaagagatccttcaaatactaaagatggaaaataaggaagtattacctcagctggtg
gatgctgtcacctctgctcagacctcagactcattagaagccattttggactttttggat
ttcaaaagtgacagcagcattatcctccaggagaggtttctctatgcctgtggatttgct
tctcatcccaatgaagaactcctgagagccctcattagtaagttcaaaggttctattggt
agcagtgacatcagagaaactgttatgatcatcactgggacacttgtcagaaagttgtgt
cagaatgaaggctgcaaactcaaagcagtagtggaagctaagaagttaatcctgggagga
cttgaaaaagcagagaaaaaagaggacaccaggatgtatctgctggctttgaagaatgcc
ctgcttccagaaggcatcccaagtcttctgaagtatgcagaagcaggagaagggcccatc
agccacctggctaccactgctctccagagatatgatctccctttcataactgatgaggtg
aagaagaccttaaacagaatataccaccaaaaccgtaaagttcatgaaaagactgtgcgc
actgctgcagctgctatcattttaaataacaatccatcctacatggacgtcaagaacatc
ctgctgtctattggggagcttccccaagaaatgaataaatacatgctcgccattgttcaa
gacatcctacgttttgaaatgcctgcaagcaaaattgtccgtcgagttctgaaggaaatg
gtcgctcacaattatgaccgtttctccaggagtggatcttcttctgcctacactggctac
atagaacgtagtccccgttcggcatctacttacagcctagacattctctactcgggttct
ggcattctaaggagaagtaacctgaacatctttcagtacattgggaaggctggtcttcac
ggtagccaggtggttattgaagcccaaggactggaagccttaatcgcagccacccctgac
gagggggaggagaaccttgactcctatgctggtatgtcagccatcctctttgatgttcag
ctcagacctgtcacctttttcaacggatacagtgatttgatgtccaaaatgctgtcagca
tctggcgaccctatcagtgtggtgaaaggacttattctgctaatagatcattctcaggaa
cttcagttacaatctggactaaaagccaatatagaggtccagggtggtctagctattgat
atttcaggtgcaatggagtttagcttgtggtatcgtgagtctaaaacccgagtgaaaaat
agggtgactgtggtaataaccactgacatcacagtggactcctcttttgtgaaagctggc
ctggaaaccagtacagaaacagaagcaggcttggagtttatctccacagtgcagttttct
cagtacccattcttagtttgcatgcagatggacaaggatgaagctccattcaggcaattt
gagaaaaagtacgaaaggctgtccacaggcagaggttatgtctctcagaaaagaaaagaa
agcgtattagcaggatgtgaattcccgctccatcaagagaactcagagatgtgcaaagtg
gtgtttgcccctcagccggatagtacttccagcggatggttttga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
Protein domain (3)   
   Pfam (3)   
All databases (63)   

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