KEGG   Homo sapiens (human): 4547
Entry
4547              CDS       T01001                                 
Symbol
MTTP, ABL, MTP
Name
(RefSeq) microsomal triglyceride transfer protein large subunit isoform 1 precursor
  KO
K14463  microsomal triglyceride transfer protein large subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa04975  Fat digestion and absorption
Disease
H00160  Abetalipoproteinemia
Drug target
Lomitapide (DG00362): D09637 D09638<JP/US>
Mitratapide: D05060
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    4547 (MTTP)
SSDB
Motif
Pfam: MTP_lip_bd TPR_Vitellogenin Vitellogenin_N
Other DBs
NCBI-GeneID: 4547
NCBI-ProteinID: NP_000244
OMIM: 157147
HGNC: 7467
UniProt: P55157
Structure
Position
4:99564130..99623997
AA seq 894 aa
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
NT seq 2685 nt   +upstreamnt  +downstreamnt
atgattcttcttgctgtgctttttctctgcttcatttcctcatattcagcttctgttaaa
ggtcacacaactggtctctcattaaataatgaccggctgtacaagctcacgtactccact
gaagttcttcttgatcggggcaaaggaaaactgcaagacagcgtgggctaccgcatttcc
tccaacgtggatgtggccttactatggaggaatcctgatggtgatgatgaccagttgatc
caaataacgatgaaggatgtaaatgttgaaaatgtgaatcagcagagaggagagaagagc
atcttcaaaggaaaaagcccatctaaaataatgggaaaggaaaacttggaagctctgcaa
agacctacgctccttcatctaatccatggaaaggtcaaagagttctactcatatcaaaat
gaggcagtggccatagaaaatatcaagagaggtctggctagcctatttcagacacagtta
agctctggaaccaccaatgaggtagatatctctggaaattgtaaagtgacctaccaggct
catcaagacaaagtgatcaaaattaaggccttggattcatgcaaaatagcgaggtctgga
tttacgaccccaaatcaggtcttgggtgtcagttcaaaagctacatctgtcaccacctat
aagatagaagacagctttgttatagctgtgcttgctgaagaaacacacaattttggactg
aatttcctacaaaccattaaggggaaaatagtatcgaagcagaaattagagctgaagaca
accgaagcaggcccaagattgatgtctggaaagcaggctgcagccataatcaaagcagtt
gattcaaagtacacggccattcccattgtggggcaggtcttccagagccactgtaaagga
tgtccttctctctcggagctctggcggtccaccaggaaatacctgcagcctgacaacctt
tccaaggctgaggctgtcagaaacttcctggccttcattcagcacctcaggactgcgaag
aaagaagagatccttcaaatactaaagatggaaaataaggaagtattacctcagctggtg
gatgctgtcacctctgctcagacctcagactcattagaagccattttggactttttggat
ttcaaaagtgacagcagcattatcctccaggagaggtttctctatgcctgtggatttgct
tctcatcccaatgaagaactcctgagagccctcattagtaagttcaaaggttctattggt
agcagtgacatcagagaaactgttatgatcatcactgggacacttgtcagaaagttgtgt
cagaatgaaggctgcaaactcaaagcagtagtggaagctaagaagttaatcctgggagga
cttgaaaaagcagagaaaaaagaggacaccaggatgtatctgctggctttgaagaatgcc
ctgcttccagaaggcatcccaagtcttctgaagtatgcagaagcaggagaagggcccatc
agccacctggctaccactgctctccagagatatgatctccctttcataactgatgaggtg
aagaagaccttaaacagaatataccaccaaaaccgtaaagttcatgaaaagactgtgcgc
actgctgcagctgctatcattttaaataacaatccatcctacatggacgtcaagaacatc
ctgctgtctattggggagcttccccaagaaatgaataaatacatgctcgccattgttcaa
gacatcctacgttttgaaatgcctgcaagcaaaattgtccgtcgagttctgaaggaaatg
gtcgctcacaattatgaccgtttctccaggagtggatcttcttctgcctacactggctac
atagaacgtagtccccgttcggcatctacttacagcctagacattctctactcgggttct
ggcattctaaggagaagtaacctgaacatctttcagtacattgggaaggctggtcttcac
ggtagccaggtggttattgaagcccaaggactggaagccttaatcgcagccacccctgac
gagggggaggagaaccttgactcctatgctggtatgtcagccatcctctttgatgttcag
ctcagacctgtcacctttttcaacggatacagtgatttgatgtccaaaatgctgtcagca
tctggcgaccctatcagtgtggtgaaaggacttattctgctaatagatcattctcaggaa
cttcagttacaatctggactaaaagccaatatagaggtccagggtggtctagctattgat
atttcaggtgcaatggagtttagcttgtggtatcgtgagtctaaaacccgagtgaaaaat
agggtgactgtggtaataaccactgacatcacagtggactcctcttttgtgaaagctggc
ctggaaaccagtacagaaacagaagcaggcttggagtttatctccacagtgcagttttct
cagtacccattcttagtttgcatgcagatggacaaggatgaagctccattcaggcaattt
gagaaaaagtacgaaaggctgtccacaggcagaggttatgtctctcagaaaagaaaagaa
agcgtattagcaggatgtgaattcccgctccatcaagagaactcagagatgtgcaaagtg
gtgtttgcccctcagccggatagtacttccagcggatggttttga

  All links  
Disease (2)   
   OMIM (2)   
Gene (8)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (52)   

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