KEGG   Homo sapiens (human): 4598Help
Entry
4598              CDS       T01001                                 

Gene name
MVK, LRBP, MK, MVLK, POROK3
Definition
(RefSeq) mevalonate kinase
  KO
K00869  mevalonate kinase [EC:2.7.1.36]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
hsa04146  Peroxisome
Module
hsa_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Disease
H00206  Mevalonate kinase deficiency
H01933  Porokeratosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    4598 (MVK)
 Cellular Processes
  Transport and catabolism
   04146 Peroxisome
    4598 (MVK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.36  mevalonate kinase
     4598 (MVK)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: GHMP_kinases_N GHMP_kinases_C GalKase_gal_bdg
Motif
Other DBs
NCBI-GeneID: 4598
NCBI-ProteinID: NP_000422
OMIM: 251170
HGNC: 7530
Ensembl: ENSG00000110921
Vega: OTTHUMG00000169256
Pharos: Q03426(Tbio)
UniProt: Q03426 B2RDU6
Structure
PDB: 

Position
12q24.11
AA seq 396 aa AA seqDB search
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
NT seq 1191 nt NT seq  +upstreamnt  +downstreamnt
atgttgtcagaagtcctactggtgtctgctccggggaaagtcatccttcatggagaacat
gccgtggtacatggcaaggtagcactggctgtatccttgaacttgagaacattcctccgg
cttcaaccccacagcaatgggaaagtggacctcagcttacccaacattggtatcaagcgg
gcctgggatgtggccaggcttcagtcactggacacaagctttctggagcaaggtgatgtc
acaacacccacctcagagcaagtggagaagctaaaggaggttgcaggcttgcctgacgac
tgtgctgtcaccgagcgcctggctgtgctggcctttctttacttatacctgtccatctgc
cggaagcagagggccctgccgagcctggatatcgtagtgtggtcggagctgccccccggg
gcgggcttgggctccagcgccgcctactcggtgtgtctggcagcagccctcctgactgtg
tgcgaggagatcccaaacccgctgaaggacggggattgcgtcaacaggtggaccaaggag
gatttggagctaattaacaagtgggccttccaaggggagagaatgattcacgggaacccc
tccggagtggacaatgctgtcagcacctggggaggagccctccgataccatcaagggaag
atttcatccttaaagaggtcgccagctctccagatcctgctgaccaacaccaaagtccct
cgcaataccagggcccttgtggctggcgtcagaaacaggctgctcaagttcccagagatc
gtggcccccctcctgacctcaatagatgccatctccctggagtgtgagcgcgtgctggga
gagatgggggaagccccagccccggagcagtacctcgtgctggaagagctcattgacatg
aaccagcaccatctgaatgccctcggcgtgggccacgcctctctggaccagctctgccag
gtgaccagggcccgcggacttcacagcaagctgactggcgcaggcggtggtggctgtggc
atcacactcctcaagccagggctggagcagccagaagtggaggccacgaagcaggccctg
accagctgtggctttgactgcttggaaaccagcatcggtgcccccggcgtctccatccac
tcagccacctccctggacagccgagtccagcaagccctggatggcctctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (6)   
   KEGG DISEASE (2)   
   OMIM (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (30)   
   RefSeq(nuc) (6)   
   GenBank (12)   
   EMBL (12)   
Protein domain (3)   
   Pfam (3)   
All databases (80)   

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