KEGG   Homo sapiens (human): 462Help
Entry
462               CDS       T01001                                 

Gene name
SERPINC1, AT3, AT3D, ATIII, ATIII-R2, THPH7
Definition
(RefSeq) serpin family C member 1
  KO
K03911  antithrombin III
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Disease
H00223  Inherited thrombophilia
H01381  Antithrombin III deficiency
H01723  Deep vein thrombosis (DVT)
Drug target
Anticoagulant heparin: D02956
Dalteparin: D03353
Danaparoid: D03644
Delparantag pentahydrochloride: D10418
Enoxaparin: D03674
Fondaparinux: D01844
Heparin (DG00150): D02112 D02980 D03673 D04427 D07510
Parnaparin: D04977
Reviparin: D03337
Sulodexide: D08547
Tinzaparin: D06398
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    462 (SERPINC1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    462 (SERPINC1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    462 (SERPINC1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other cancer cells
   462 (SERPINC1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate/Haparin
  Coagulation and fibrinolysis
   462 (SERPINC1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Serpin
Motif
Other DBs
NCBI-GeneID: 462
NCBI-ProteinID: NP_000479
OMIM: 107300
HGNC: 775
Ensembl: ENSG00000117601
Vega: OTTHUMG00000037276
Pharos: P01008(Tclin)
UniProt: P01008 A0A024R944
Structure
PDB: 

Position
1q25.1
AA seq 464 aa AA seqDB search
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
NT seq 1395 nt NT seq  +upstreamnt  +downstreamnt
atgtattccaatgtgataggaactgtaacctctggaaaaaggaaggtttatcttttgtcc
ttgctgctcattggcttctgggactgcgtgacctgtcacgggagccctgtggacatctgc
acagccaagccgcgggacattcccatgaatcccatgtgcatttaccgctccccggagaag
aaggcaactgaggatgagggctcagaacagaagatcccggaggccaccaaccggcgtgtc
tgggaactgtccaaggccaattcccgctttgctaccactttctatcagcacctggcagat
tccaagaatgacaatgataacattttcctgtcacccctgagtatctccacggcttttgct
atgaccaagctgggtgcctgtaatgacaccctccagcaactgatggaggtatttaagttt
gacaccatatctgagaaaacatctgatcagatccacttcttctttgccaaactgaactgc
cgactctatcgaaaagccaacaaatcctccaagttagtatcagccaatcgcctttttgga
gacaaatcccttaccttcaatgagacctaccaggacatcagtgagttggtatatggagcc
aagctccagcccctggacttcaaggaaaatgcagagcaatccagagcggccatcaacaaa
tgggtgtccaataagaccgaaggccgaatcaccgatgtcattccctcggaagccatcaat
gagctcactgttctggtgctggttaacaccatttacttcaagggcctgtggaagtcaaag
ttcagccctgagaacacaaggaaggaactgttctacaaggctgatggagagtcgtgttca
gcatctatgatgtaccaggaaggcaagttccgttatcggcgcgtggctgaaggcacccag
gtgcttgagttgcccttcaaaggtgatgacatcaccatggtcctcatcttgcccaagcct
gagaagagcctggccaaggtagagaaggaactcaccccagaggtgctgcaagagtggctg
gatgaattggaggagatgatgctggtggtccacatgccccgcttccgcattgaggacggc
ttcagtttgaaggagcagctgcaagacatgggccttgtcgatctgttcagccctgaaaag
tccaaactcccaggtattgttgcagaaggccgagatgacctctatgtctcagatgcattc
cataaggcatttcttgaggtaaatgaagaaggcagtgaagcagctgcaagtaccgctgtt
gtgattgctggccgttcgctaaaccccaacagggtgactttcaaggccaacaggcctttc
ctggtttttataagagaagttcctctgaacactattatcttcatgggcagagtagccaac
ccttgtgttaagtaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (3)   
   OMIM (2)   
Drug (15)   
   KEGG DRUG (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   PROTHERM (3)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
Protein domain (1)   
   Pfam (1)   
All databases (70)   

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