KEGG   Homo sapiens (human): 462Help
Entry
462               CDS       T01001                                 

Gene name
SERPINC1, AT3, AT3D, ATIII, ATIII-R2, THPH7
Definition
(RefSeq) serpin family C member 1
  KO
K03911  antithrombin III
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Disease
H00223  Inherited thrombophilia
H01381  Antithrombin III deficiency
H01723  Deep vein thrombosis
Drug target
Anticoagulant heparin: D02956
Dalteparin: D03353
Danaparoid: D03644
Delparantag pentahydrochloride: D10418
Enoxaparin: D03674
Fondaparinux: D01844
Heparin (DG00150): D02112 D02980 D03673 D04427 D07510
Parnaparin: D04977
Reviparin: D03337
Sulodexide: D08547
Tinzaparin: D06398
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    462 (SERPINC1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    462 (SERPINC1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    462 (SERPINC1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other cancer cells
   462 (SERPINC1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate/Haparin
  Coagulation and fibrinolysis
   462 (SERPINC1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Serpin Dynein_attach_N
Motif
Other DBs
NCBI-GeneID: 462
NCBI-ProteinID: NP_000479
OMIM: 107300
HGNC: 775
Ensembl: ENSG00000117601
Vega: OTTHUMG00000037276
Pharos: P01008(Tclin)
UniProt: P01008 A0A024R944
Structure
PDB: 

Position
1q25.1
AA seq 464 aa AA seqDB search
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
NT seq 1395 nt NT seq  +upstreamnt  +downstreamnt
atgtattccaatgtgataggaactgtaacctctggaaaaaggaaggtttatcttttgtcc
ttgctgctcattggcttctgggactgcgtgacctgtcacgggagccctgtggacatctgc
acagccaagccgcgggacattcccatgaatcccatgtgcatttaccgctccccggagaag
aaggcaactgaggatgagggctcagaacagaagatcccggaggccaccaaccggcgtgtc
tgggaactgtccaaggccaattcccgctttgctaccactttctatcagcacctggcagat
tccaagaatgacaatgataacattttcctgtcacccctgagtatctccacggcttttgct
atgaccaagctgggtgcctgtaatgacaccctccagcaactgatggaggtatttaagttt
gacaccatatctgagaaaacatctgatcagatccacttcttctttgccaaactgaactgc
cgactctatcgaaaagccaacaaatcctccaagttagtatcagccaatcgcctttttgga
gacaaatcccttaccttcaatgagacctaccaggacatcagtgagttggtatatggagcc
aagctccagcccctggacttcaaggaaaatgcagagcaatccagagcggccatcaacaaa
tgggtgtccaataagaccgaaggccgaatcaccgatgtcattccctcggaagccatcaat
gagctcactgttctggtgctggttaacaccatttacttcaagggcctgtggaagtcaaag
ttcagccctgagaacacaaggaaggaactgttctacaaggctgatggagagtcgtgttca
gcatctatgatgtaccaggaaggcaagttccgttatcggcgcgtggctgaaggcacccag
gtgcttgagttgcccttcaaaggtgatgacatcaccatggtcctcatcttgcccaagcct
gagaagagcctggccaaggtagagaaggaactcaccccagaggtgctgcaagagtggctg
gatgaattggaggagatgatgctggtggtccacatgccccgcttccgcattgaggacggc
ttcagtttgaaggagcagctgcaagacatgggccttgtcgatctgttcagccctgaaaag
tccaaactcccaggtattgttgcagaaggccgagatgacctctatgtctcagatgcattc
cataaggcatttcttgaggtaaatgaagaaggcagtgaagcagctgcaagtaccgctgtt
gtgattgctggccgttcgctaaaccccaacagggtgactttcaaggccaacaggcctttc
ctggtttttataagagaagttcctctgaacactattatcttcatgggcagagtagccaac
ccttgtgttaagtaa

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