KEGG   Homo sapiens (human): 462
Entry
462               CDS       T01001                                 
Symbol
SERPINC1, AT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2, THPH7
Name
(RefSeq) serpin family C member 1
  KO
K03911  antithrombin III
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
  Element
N01519  Regulation of coagulation cascade, AT3
Disease
H00223  Inherited thrombophilia
H01381  Antithrombin III deficiency
H01723  Deep vein thrombosis
Drug target
Anticoagulant heparin: D02956
Dalteparin: D03353<JP/US>
Danaparoid: D03644
Delparantag pentahydrochloride: D10418
Enoxaparin: D03674<JP/US>
Fitusiran sodium: D11810<US>
Fondaparinux: D01844<JP/US>
Heparin (DG00150): D02112<JP/US> D02980 D03673 D04427<JP> D07510
Parnaparin: D04977<JP>
Reviparin: D03337
Sulodexide: D08547
Tinzaparin: D06398
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    462 (SERPINC1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    462 (SERPINC1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    462 (SERPINC1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    462 (SERPINC1)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I4: serpin family
   462 (SERPINC1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other cancer cells
   462 (SERPINC1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   462 (SERPINC1)
SSDB
Motif
Pfam: Serpin
Other DBs
NCBI-GeneID: 462
NCBI-ProteinID: NP_000479
OMIM: 107300
HGNC: 775
Ensembl: ENSG00000117601
UniProt: P01008
Structure
Position
1:complement(173903800..173917327)
AA seq 464 aa
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
NT seq 1395 nt   +upstreamnt  +downstreamnt
atgtattccaatgtgataggaactgtaacctctggaaaaaggaaggtttatcttttgtcc
ttgctgctcattggcttctgggactgcgtgacctgtcacgggagccctgtggacatctgc
acagccaagccgcgggacattcccatgaatcccatgtgcatttaccgctccccggagaag
aaggcaactgaggatgagggctcagaacagaagatcccggaggccaccaaccggcgtgtc
tgggaactgtccaaggccaattcccgctttgctaccactttctatcagcacctggcagat
tccaagaatgacaatgataacattttcctgtcacccctgagtatctccacggcttttgct
atgaccaagctgggtgcctgtaatgacaccctccagcaactgatggaggtatttaagttt
gacaccatatctgagaaaacatctgatcagatccacttcttctttgccaaactgaactgc
cgactctatcgaaaagccaacaaatcctccaagttagtatcagccaatcgcctttttgga
gacaaatcccttaccttcaatgagacctaccaggacatcagtgagttggtatatggagcc
aagctccagcccctggacttcaaggaaaatgcagagcaatccagagcggccatcaacaaa
tgggtgtccaataagaccgaaggccgaatcaccgatgtcattccctcggaagccatcaat
gagctcactgttctggtgctggttaacaccatttacttcaagggcctgtggaagtcaaag
ttcagccctgagaacacaaggaaggaactgttctacaaggctgatggagagtcgtgttca
gcatctatgatgtaccaggaaggcaagttccgttatcggcgcgtggctgaaggcacccag
gtgcttgagttgcccttcaaaggtgatgacatcaccatggtcctcatcttgcccaagcct
gagaagagcctggccaaggtagagaaggaactcaccccagaggtgctgcaagagtggctg
gatgaattggaggagatgatgctggtggtccacatgccccgcttccgcattgaggacggc
ttcagtttgaaggagcagctgcaagacatgggccttgtcgatctgttcagccctgaaaag
tccaaactcccaggtattgttgcagaaggccgagatgacctctatgtctcagatgcattc
cataaggcatttcttgaggtaaatgaagaaggcagtgaagcagctgcaagtaccgctgtt
gtgattgctggccgttcgctaaaccccaacagggtgactttcaaggccaacaggcctttc
ctggtttttataagagaagttcctctgaacactattatcttcatgggcagagtagccaac
ccttgtgttaagtaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (13)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PROTHERM (3)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (33)   
   RefSeq(nuc) (7)   
   GenBank (13)   
   EMBL (13)   
3D Structure (27)   
   PDB (27)   
Protein domain (1)   
   Pfam (1)   
All databases (85)   

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