KEGG   Homo sapiens (human): 4620
Entry
4620              CDS       T01001                                 
Symbol
MYH2, CMYO6, CMYP6, IBM3, MYH2A, MYHSA2, MYHas8, MYPOP, MyHC-2A, MyHC-IIa
Name
(RefSeq) myosin heavy chain 2
  KO
K24220  myosin heavy chain 1/2/3/4/8/13/7B/15
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
Network
nt06539  Cytoskeleton in muscle cells
  Element
N01817  Myosin thick filament
N01818  Actin thin filament, muscle contraction
Disease
H01229  Inclusion body myopathy 3
H01810  Congenital myopathy
Drug target
Sevasemten: D12902
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    4620 (MYH2)
   04820 Cytoskeleton in muscle cells
    4620 (MYH2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4620 (MYH2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     4620 (MYH2)
SSDB
Motif
Pfam: Myosin_head Myosin_tail_1 Myosin_N Crescentin IQ AAA_22 AAA_16
Other DBs
NCBI-GeneID: 4620
NCBI-ProteinID: NP_001093582
OMIM: 160740
HGNC: 7572
Ensembl: ENSG00000125414
UniProt: Q9UKX2
Position
17:complement(10521148..10549658)
AA seq 1941 aa
MSSDSELAVFGEAAPFLRKSERERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKV
TVKTEGGATLTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSG
LFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE
SGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTLEDQIISANPLLEAFGNAKTVR
NDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAERSYHIFYQITSNKKPEL
IEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNEEKVSIYKLTGAVM
HYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTV
EQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYAGVVDYNITGWLEKN
KDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGKKKGSSFQTVSALFREN
LNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRIL
YADFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLE
EMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFF
KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE
AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI
DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE
DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ
QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEK
QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK
KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED
QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE
LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK
YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER
TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ
LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE
EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL
KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV
ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI
SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ
LRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQT
EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE
SQVNKLRVKSREVHTKVISEE
NT seq 5826 nt   +upstreamnt  +downstreamnt
atgagttcagactcagaattggctgtttttggggaggctgctcctttcctccgaaagtct
gaaagggagcgcattgaggcccagaataggccctttgatgccaaaacatctgtctttgtg
gcggagcccaaagaatcctttgtcaaagggaccatccagagcagagaaggaggaaaagtg
acggtgaagactgagggaggagcgactctgacagtgaaggatgatcaggtcttccccatg
aaccctcccaaatatgacaagatcgaggatatggccatgatgactcatctgcatgagcct
gctgtgctgtacaacctcaaagaacgttatgcagcctggatgatctacacctattcaggt
ctcttctgtgtcactgtcaacccctacaagtggctgcctgtgtataagcccgaggtggtg
acagcctaccgaggcaaaaagcgccaggaggccccgccccacatcttctccatctctgac
aacgcctatcagttcatgctgactgaccgagagaatcagtcaatcctgatcactggagaa
tctggtgcagggaagactgtgaacaccaagcgtgtcatccagtactttgcaacaattgca
gttactggtgagaagaagaaggaagaaattacttctggcaaaatacaggggactctggaa
gatcaaatcatcagtgccaaccccctactggaggcctttggcaacgccaagaccgtgagg
aatgacaactcctctcgctttggtaaattcatcagaatccactttggcactactggaaaa
ctggcatctgctgatattgaaacatatctgctagagaagtctagagttgttttccagctt
aaggctgagagaagttatcatattttttaccagattacatcgaataagaaaccagaactt
attgaaatgcttctgattaccacgaacccatatgattacccatttgtcagtcaaggggag
atcagtgtggccagcatcgatgatcaggaagaactgatggccacagatagtgctattgat
attttgggctttactaatgaagaaaaggtctccatttacaagctcacgggggctgtgatg
cattatgggaacctaaaatttaagcaaaagcagcgtgaggagcaagcagagccagatggc
acagaagttgctgacaaggcggcctacctccagagtctgaactctgcagatctgctcaaa
gctctctgctaccccagggtcaaggtcggcaatgagtatgtcaccaaaggccagactgta
gaacaggtgtccaacgcagtaggtgctctggccaaagccgtctacgagaagatgttcctg
tggatggttgcccgcatcaaccagcagctggacaccaagcagcccaggcagtacttcatc
ggggtcttggacattgctggttttgagatttttgatttcaacagcctggagcagctgtgc
atcaacttcaccaatgagaaactgcaacagtttttcaaccaccacatgttcgtgctggag
caggaggagtacaagaaggaaggcatcgagtggacgttcatcgacttcgggatggacctg
gctgcctgcatcgagctcatcgagaagcctatgggcatcttctccatcctggaagaggag
tgcatgttccctaaggcaacagacacctccttcaagaacaagctgtatgaccagcacctg
ggcaagtctgccaacttccagaagcccaaggtggtcaaaggcaaggccgaggcccacttc
gctctgattcactatgctggtgttgtggactacaacattactggctggctggagaagaac
aaggaccccctgaatgagaccgtggttggactgtaccagaagtctgcaatgaaaactcta
gctcagctcttctctggggctcaaactgctgaaggagagggagctggtggaggggccaag
aaaggtggtaagaagaagggctcttctttccagacagtgtctgcccttttcagagagaat
ttgaacaagctgatgaccaacctcaggagtacccatcctcactttgtgaggtgtatcatc
cccaatgagacaaaaactcctggtgccatggagcatgagcttgtcctccaccagctgagg
tgtaacggtgtgctggaaggcatccgcatctgtaggaaaggatttccaagcagaatcctt
tatgcagacttcaaacagagatacaaggtattaaatgcaagtgcaatccctgaagggcaa
ttcattgatagcaagaaggcctctgagaagctccttgcatccatcgacattgaccacacc
cagtataaatttgggcacaccaaggtctttttcaaagctggtcttctggggctcctagag
gagatgcgagatgacaagctggcccagctgattacccgaacccaggccaggtgcagaggg
ttcttggcaagagtggagtaccagaggatggtggagagaagggaggccatcttctgtatc
cagtacaatatcagatccttcatgaatgtcaagcactggccctggatgaaactcttcttc
aagatcaagcctctgttgaagagtgcagaaactgagaaggagatggccaccatgaaggaa
gaatttcagaaaattaaagacgaacttgccaagtcagaggcaaaaaggaaggaactggaa
gaaaagatggtgacgctgttgaaagaaaaaaatgacttgcagctccaagttcaggctgaa
gccgaaggcttggctgatgcagaggaaaggtgtgaccagctaatcaaaaccaaaatccag
ctagaagccaaaatcaaagaggtgactgagagagctgaggatgaggaagagatcaatgct
gagctgacagccaagaagaggaaactggaggatgaatgttcagaactcaagaaagacatt
gatgaccttgagctgacactggccaaggttgagaaggagaaacatgccacagaaaacaag
gtgaaaaacctcacagaagagatggcaggtctggatgaaaccattgctaagctgaccaag
gagaagaaggctctccaggaggcccaccagcagaccctggatgacctgcaggcagaggag
gacaaagtcaacaccctgaccaaagctaaaatcaaacttgaacaacaagtggatgatctt
gaagggtccttggagcaagaaaagaaacttcgcatggacctagaaagggctaagaggaaa
cttgagggtgacttgaagttggcccaagaatccataatggacattgaaaatgagaaacag
caacttgatgaaaagctcaaaaagaaagagtttgaaatcagcaatctgcaaagcaagatt
gaagatgaacaggcacttggcattcaattgcagaagaaaattaaagaattgcaagcccgc
attgaggagctggaggaggaaatcgaggcagagcgggcctcccgggccaaagcagagaag
cagcgctctgacctctcccgggagctggaggagatcagcgagaggctggaagaagccggt
ggggccacttcagcccagattgagatgaacaagaagcgggaggctgagttccagaaaatg
cgcagggacctggaggaggccaccctacagcatgaagccacagcggccaccctgaggaag
aagcatgcagatagtgtggccgagcttggggagcagattgacaacctgcagcgagtgaag
cagaagctggagaaggagaagagtgagatgaagatggagattgatgaccttgctagtaat
gtagaaacggtctccaaagccaagggaaacctagagaaaatgtgccggactctagaggac
caactgagtgaactgaaatcaaaggaagaggagcagcagcggctgatcaatgacctgact
gcgcagagggggcgcctgcagactgaatctggtgagttttcacgccagcttgatgaaaag
gaagctctggtgtctcagttatcaagaggcaaacaagcctttactcaacagattgaagaa
ttaaagaggcaacttgaagaggagataaaagccaagaacgccctggcgcatgccctgcag
tcttcccgccacgactgtgacctgctgcgggaacagtatgaggaggagcaggaatccaag
gccgagctgcagagagcactgtccaaggccaacaccgaggttgcccaatggaggaccaaa
tacgagacggacgccatccagcgcacagaggagctggaggaggccaagaagaagctggcc
cagcggctgcaggcagctgaggaacatgtagaagctgtgaacgccaaatgtgcttccctc
gaaaagacgaagcagcggctgcagaatgaggtcgaggacctcatgcttgatgtggagagg
acaaatgccgcctgtgccgcccttgacaaaaagcaaaggaacttcgataagatcctggca
gaatggaaacagaaatgtgaggaaacgcatgctgagcttgaggcctcccagaaggaggcc
cgttcccttggcactgagctgttcaagataaagaatgcctatgaggaatctttggatcag
ctagaaaccctgaagcgagagaacaaaaacttacagcaggagatttctgacctcacggaa
cagattgcagaaggagggaaacgtatccatgaactggagaaaataaagaaacaagtggaa
caagaaaagtgtgaacttcaggctgctttagaagaagcagaggcatctcttgaacatgaa
gagggaaagatcctgcgcatccagcttgagttgaaccaagtcaagtctgaggttgatagg
aaaattgctgaaaaagatgaggaaattgaccagctgaagagaaaccacattagaatcgtg
gagtccatgcagagcacgctggatgctgagatcaggagtaggaatgatgccattaggctc
aagaagaagatggagggagacctcaatgaaatggaaatccagctgaaccatgccaaccgc
atggctgctgaggccctgaggaactacaggaacacccaaggcatcctcaaggatacccag
atccacctggatgatgctctccggagccaggaggacctgaaggaacagctggccatggtg
gagcgcagagccaacctgctgcaggctgagatcgaggagctgcgggccactctggaacag
acagagaggagcagaaaaatcgcagaacaggagctcctggatgccagtgagcgtgttcag
ctactgcacacccagaacaccagcctgatcaacaccaagaagaagctggagacagatatt
tcccaaatgcaaggagagatggaggacattctccaggaagcccgcaatgcagaagaaaag
gccaagaaggccatcactgatgccgccatgatggctgaggagctgaagaaggagcaggac
accagcgcccacctggagcggatgaagaagaacatggagcagaccgtgaaggatctgcag
ctccgtctggatgaggctgagcagctggccctgaagggtgggaagaagcagatccagaaa
ctggaggccagggtacgggagctggaaggagaggttgagagtgagcaaaagcgtaatgct
gaggctgtcaaaggtctgcgcaaacatgagaggcgagtgaaggaactcacttaccagacg
gaagaagatagaaagaatattctcaggcttcaagatttggtagataaacttcaggcaaaa
gtgaaatcttataagagacaagctgaggaggctgaggaacaatccaacaccaatctagct
aaattccgcaagctccagcatgagctggaggaggccgaggaacgggctgacattgctgag
tcccaggtgaacaaactgcgggtgaagagccgggaggttcacacaaaagtcataagtgaa
gagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (24)   
   RefSeq(nuc) (2)   
   GenBank (11)   
   EMBL (11)   
Protein domain (7)   
   Pfam (7)   
All databases (63)   

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