KEGG   Homo sapiens (human): 4634
Entry
4634              CDS       T01001                                 
Symbol
MYL3, CMH8, MLC-lV/sb, MLC1SB, MLC1V, VLC1, VLCl
Name
(RefSeq) myosin light chain 3
  KO
K12749  myosin light chain 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06539  Cytoskeleton in muscle cells
  Element
N01817  Myosin thick filament
Disease
H00292  Hypertrophic cardiomyopathy
Drug target
Aficamten: D12253
Delocamten: D12949
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    4634 (MYL3)
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    4634 (MYL3)
   04820 Cytoskeleton in muscle cells
    4634 (MYL3)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4634 (MYL3)
   04261 Adrenergic signaling in cardiomyocytes
    4634 (MYL3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    4634 (MYL3)
   05414 Dilated cardiomyopathy
    4634 (MYL3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4634 (MYL3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     4634 (MYL3)
SSDB
Motif
Pfam: EF-hand_1 EF-hand_7 EF-hand_6 AIF-1 EF_EFCAB10_C DUF2267
Other DBs
NCBI-GeneID: 4634
NCBI-ProteinID: NP_000249
OMIM: 160790
HGNC: 7584
Ensembl: ENSG00000160808
UniProt: P08590
Structure
Position
3:complement(46857872..46882182)
AA seq 195 aa
MAPKKPEPKKDDAKAAPKAAPAPAPPPEPERPKEVEFDASKIKIEFTPEQIEEFKEAFML
FDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPMLQH
ISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSN
GCINYEAFVKHIMSS
NT seq 588 nt   +upstreamnt  +downstreamnt
atggcccccaaaaagccagagcccaagaaggatgatgccaaggcagcccccaaggcagct
ccagctcccgcacctccccctgagcctgagcgccctaaggaggtcgagtttgatgcttcc
aagatcaagattgagttcacacctgagcagattgaagagttcaaggaagccttcatgctg
ttcgaccgcacacccaagtgtgagatgaagatcacctacgggcagtgtggggatgtcctg
cgggcgctgggccagaaccccacacaggcagaagtgctccgtgtcctggggaagccaaga
caggaagagctcaataccaagatgatggactttgaaactttcctgcctatgctccagcac
atttccaagaacaaggacacaggcacctatgaggacttcgtggaggggctgcgggtcttc
gacaaggagggcaatggcactgtcatgggtgctgagcttcgccacgtgctggccacgctg
ggtgagaggctgacagaagacgaagtggagaagttgatggctgggcaagaggactccaat
ggctgcatcaactatgaagcatttgtgaagcacatcatgtccagctaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (7)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (20)   
   RefSeq(nuc) (6)   
   GenBank (7)   
   EMBL (7)   
3D Structure (9)   
   PDB (9)   
Protein domain (6)   
   Pfam (6)   
All databases (52)   

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