KEGG   Homo sapiens (human): 4705
Entry
4705              CDS       T01001                                 
Symbol
NDUFA10, CI-42KD, CI-42k, MC1DN22
Name
(RefSeq) NADH:ubiquinone oxidoreductase subunit A10
  KO
K03954  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04714  Thermogenesis
hsa04723  Retrograde endocannabinoid signaling
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex
Network
nt06460  Alzheimer disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00995  Electron transfer in Complex I
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01042  Mutation-caused aberrant SNCA to electron transfer in Complex I
N01043  Mutation-inactivated PINK1 to electron transfer in Complex I
N01044  MPP+ to electron transfer in Complex I
N01045  Rotenone to electron transfer in Complex I
N01136  Mutation-caused aberrant TDP43 to electron transfer in Complex I
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H00473  Mitochondrial complex I deficiency
H01354  Leigh syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4705 (NDUFA10)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    4705 (NDUFA10)
  09159 Environmental adaptation
   04714 Thermogenesis
    4705 (NDUFA10)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4705 (NDUFA10)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4705 (NDUFA10)
   05012 Parkinson disease
    4705 (NDUFA10)
   05014 Amyotrophic lateral sclerosis
    4705 (NDUFA10)
   05016 Huntington disease
    4705 (NDUFA10)
   05020 Prion disease
    4705 (NDUFA10)
   05022 Pathways of neurodegeneration - multiple diseases
    4705 (NDUFA10)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4705 (NDUFA10)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4705 (NDUFA10)
SSDB
Motif
Pfam: dNK AAA_17 AAA_28 Thymidylate_kin Cytidylate_kin AAA_18 Cytidylate_kin2 TsaE
Other DBs
NCBI-GeneID: 4705
NCBI-ProteinID: NP_004535
OMIM: 603835
HGNC: 7684
Ensembl: ENSG00000130414
UniProt: O95299
Position
2:complement(239892442..240025342)
AA seq 355 aa
MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVI
TVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDD
PRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIR
KQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENA
YKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQD
KFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFRELPGRKYSPGYNTEVGDKWIWLK
NT seq 1068 nt   +upstreamnt  +downstreamnt
atggccttgcggctcctgaagctggcagcgacgtccgcgtccgcccgggtcgtggcggcg
ggcgcccagcgcgtgagaggaattcatagcagtgtgcagtgcaaactgcgctatggaatg
tggcatttcctacttggggataaagcaagcaaaagactgacagaacgcagcagagtgata
actgtagatggcaatatatgtactggaaaaggcaaacttgcaaaagaaatagcagagaaa
ctaggcttcaagcactttcctgaagcggggattcattatccagacagtaccacaggagat
gggaagcccctcgccaccgactataatggcaactgtagtttggagaaattttacgatgat
ccgagaagcaatgatggcaacagttaccgcctgcagtcctggttgtacagcagtcgcctg
ctgcagtactcagatgccttggagcacttgctgaccacaggacaaggtgttgtgttggag
cgctccatcttcagtgactttgtgttcctggaggcgatgtacaaccagggattcatccga
aagcagtgtgtggaccactacaacgaggtgaagagcgtcaccatctgcgattacctgccc
ccccacctggtgatttacatcgatgtgcccgttccagaggtccagaggcggattcagaag
aaaggagatccacatgaaatgaagatcacctctgcctatctacaggacattgagaatgcc
tataagaaaacctttctccctgagatgagtgaaaaatgtgaggttttacaatattctgca
agggaagctcaagattcaaaaaaggtggtagaggacattgaatacctgaagttcgataaa
gggccgtggctcaagcaggacaatcgcactttataccacctgcgattactggttcaggat
aagtttgaggtgctgaattacacaagcattcctatctttctcccggaagtcaccattgga
gctcatcagactgaccgtgtcttacatcagttcagagagctgccgggccgcaagtacagc
cctgggtacaacaccgaggtgggagacaagtggatctggctgaagtga

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