KEGG   Homo sapiens (human): 4750
Entry
4750              CDS       T01001                                 

Gene name
NEK1, ALS24, NY-REN-55, SRPS2, SRPS2A, SRTD6
Definition
(RefSeq) NIMA related kinase 1
  KO
K08857  NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00511  Short rib-polydactyly syndrome
H02157  Short-rib thoracic dysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4750 (NEK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    4750 (NEK1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    4750 (NEK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     4750 (NEK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  NEK family
   4750 (NEK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other cilium assembly proteins
    4750 (NEK1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    4750 (NEK1)
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like APH Pkinase_fungal
Other DBs
NCBI-GeneID: 4750
NCBI-ProteinID: NP_036356
OMIM: 604588
HGNC: 7744
Ensembl: ENSG00000137601
Vega: OTTHUMG00000160963
Pharos: Q96PY6(Tbio)
UniProt: Q96PY6
Structure
PDB: 
4B9D 4APC

Position
4q33
AA seq 1258 aa
MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH
PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH
DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY
NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK
RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI
SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE
EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE
VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL
PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR
KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM
RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE
TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL
KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS
TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG
EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET
EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD
IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH
LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID
EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP
TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE
KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE
NT seq 3777 nt   +upstreamnt  +downstreamnt
atggagaagtatgttagactacagaagattggagaaggttcatttggaaaagccattctt
gttaaatctacagaagatggcagacagtatgttatcaaggaaattaacatctcaagaatg
tccagtaaagaaagagaagaatcaaggagagaagttgcagtattggcaaacatgaagcat
ccaaatattgtccagtatagagaatcatttgaagaaaatggctctctctacatagtaatg
gattactgtgagggaggggatctgtttaagcgaataaatgctcagaaaggcgttttgttt
caagaggatcagattttggactggtttgtacagatatgtttggccctgaaacatgtacat
gatagaaaaattcttcatcgagacattaaatctcagaacatatttttaactaaagatgga
acagtacaacttggagattttggaattgctagagttcttaatagtactgtagagctggct
cgaacttgcatagggaccccatactacttgtcacctgaaatctgtgaaaacaaaccttac
aataataaaagtgacatttgggctctggggtgtgtcctttatgagctgtgtacacttaaa
catgcttttgaagctggcagtatgaaaaacctggtactgaagataatatctggatctttt
ccacctgtgtctttgcattattcctatgatctccgcagtttggtgtctcagttatttaaa
agaaatcctagggatagaccatcagtcaactccatattggagaaaggttttatagccaaa
cgcattgaaaagtttctctctcctcagcttattgcagaagaattttgtctaaaaacattt
tcgaagtttggatcacagcctataccagctaaaagaccagcttcaggacaaaactcgatt
tctgttatgcctgctcagaaaattacaaagcctgccgctaaatatggaatacctttagca
tataagaaatatggagataaaaaattacacgaaaagaaaccactgcaaaaacataaacag
gcccatcaaactccagagaagagagtgaatactggagaagaaaggaggaaaatatctgag
gaagcagcaagaaagagaaggctggaatttattgaaaaagaaaagaaacaaaaggatcag
attattagtttaatgaaggctgaacaaatgaaaaggcaagaaaaggaaaggttggaaaga
ataaatagggccagggaacaaggatggagaaatgtgctaagtgctggtggaagtggtgaa
gtaaaggctccttttctgggcagtggagggactatagctccatcatctttttcttctcga
ggacagtatgaacattaccatgccatttttgaccaaatgcagcaacaaagagcagaagat
aatgaagctaaatggaaaagagaaatatatggtcgaggtcttccagaaagaggaattctg
cctggagttcgtccaggatttccttatggggctgcaggtcatcaccattttcctgatgct
gatgatattagaaaaactttgaaaagattgaaggcggtgtctaaacaagccaatgcaaac
aggcaaaaagggcagctagctgtagaaagagctaaacaagtagaagagttcctgcagcga
aaacgggaagctatgcagaataaagctcgagccgaaggacatatggtttatctggcaaga
ctgaggcaaataagactacagaatttcaatgagcgccaacagattaaagccaaacttcgt
ggtgaaaagaaagaagctaatcattctgaaggacaagaaggaagtgaagaggctgacatg
aggcgcaaaaaaatcgaatcactgaaggcccatgcaaatgcacgtgctgctgtactaaaa
gaacaactagaacgaaagagaaaggaggcttatgagagagaaaaaaaagtgtgggaagag
catttggtggctaaaggagttaagagttctgatgtttctccacctttgggacagcatgaa
acaggtggctctccatcaaagcaacagatgagatctgttatttctgtaacttcagctttg
aaagaagttggcgtggacagtagtttaactgatacccgggaaacttcagaagagatgcaa
aagaccaacaatgctatttcaagtaagcgagaaatacttcgtagattaaatgaaaatctt
aaagctcaagaagatgaaaaaggaaagcagaatctctctgatacttttgagataaatgtt
catgaagatgccaaagagcatgaaaaagaaaaatcagtttcatctgatcgcaagaagtgg
gaggcaggaggtcaacttgtgattcctctggatgagttaacactagatacatccttctct
acaactgaaagacatacagtgggagaagttattaaattaggtcctaatggatctccaaga
agagcctgggggaaaagtccgacagattctgttctaaagatacttggagaagctgaacta
caacttcagacagaactattagaaaatacaactattagaagtgagatttctcccgaaggg
gaaaagtacaaacccttaattactggagaaaaaaaagtacaatgtatttcacatgaaata
aacccatcagctattgttgattctcctgttgagacaaaaagtcccgagttcagtgaggca
tctccacagatgtcattgaaactggaaggaaatttagaagaacctgatgatttggaaaca
gaaattctacaagagccaagtggaacaaacaaagatgagagcttgccatgcactattact
gatgtgtggattagtgaggaaaaagaaacaaaggaaactcagtcggcagataggatcacc
attcaggaaaatgaagtttctgaagatggagtctcgagtactgtggaccaacttagtgac
attcatatagagcctggaaccaatgattctcagcactctaaatgtgatgtagataagtct
gtgcaaccggaaccatttttccataaggtggttcattctgaacacttgaacttagtccct
caagttcaatcagttcagtgttcaccagaagaatcctttgcatttcgatctcactcgcat
ttaccaccaaaaaataaaaacaagaattccttgctgattggactttcaactggtctgttt
gatgcaaacaacccaaagatgttaaggacatgttcacttccagatctctcaaagctgttc
agaacccttatggatgttcccaccgtaggagatgttcgtcaagacaatcttgaaatagat
gaaattgaagatgaaaacattaaagaaggaccttctgattctgaagacattgtgtttgaa
gaaactgacacagatttacaagagctgcaggcctcgatggaacagttacttagggaacaa
cctggtgaagaatacagtgaagaagaagagtcagtcttgaagaacagtgatgtggagcca
actgcaaatgggacagatgtggcagatgaagatgacaatcccagcagtgaaagtgccctg
aacgaagaatggcactcagataacagtgatggtgaaattgctagtgaatgtgaatgcgat
agtgtctttaaccatttagaggaactgagacttcatctggagcaggaaatgggctttgaa
aaattctttgaggtttatgagaaaataaaggctattcatgaagatgaagatgaaaatatt
gaaatttgttcaaaaatagttcaaaatattttgggaaatgaacatcagcatctttatgcc
aagattcttcatttagtcatggcagatggagcctaccaagaagataatgatgaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (22)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (54)   
   RefSeq(nuc) (24)   
   GenBank (15)   
   EMBL (15)   
Protein domain (5)   
   Pfam (5)   
All databases (118)   

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