KEGG   Homo sapiens (human): 4750
Entry
4750              CDS       T01001                                 
Symbol
NEK1, ALS24, NY-REN-55, OFD2, SRPS2, SRPS2A, SRTD6
Name
(RefSeq) NIMA related kinase 1
  KO
K08857  serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00454  Oral-facial-digital syndrome
H00511  Short rib-polydactyly syndrome
H02157  Short-rib thoracic dysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4750 (NEK1)
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    4750 (NEK1)
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    4750 (NEK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     4750 (NEK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  NEK family
   4750 (NEK1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    4750 (NEK1)
Cilium and associated proteins [BR:hsa03037]
 Primary cilia and associated proteins
  Other primary cilia associated proteins
   4750 (NEK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 4750
NCBI-ProteinID: NP_036356
OMIM: 604588
HGNC: 7744
Ensembl: ENSG00000137601
UniProt: Q96PY6
Structure
Position
4:complement(169392809..169612583)
AA seq 1258 aa
MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH
PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH
DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY
NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK
RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSI
SVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISE
EAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGE
VKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGIL
PGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQR
KREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADM
RRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHE
TGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENL
KAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFS
TTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEG
EKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLET
EILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSD
IHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSH
LPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEID
EIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEP
TANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFE
KFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE
NT seq 3777 nt   +upstreamnt  +downstreamnt
atggagaagtatgttagactacagaagattggagaaggttcatttggaaaagccattctt
gttaaatctacagaagatggcagacagtatgttatcaaggaaattaacatctcaagaatg
tccagtaaagaaagagaagaatcaaggagagaagttgcagtattggcaaacatgaagcat
ccaaatattgtccagtatagagaatcatttgaagaaaatggctctctctacatagtaatg
gattactgtgagggaggggatctgtttaagcgaataaatgctcagaaaggcgttttgttt
caagaggatcagattttggactggtttgtacagatatgtttggccctgaaacatgtacat
gatagaaaaattcttcatcgagacattaaatctcagaacatatttttaactaaagatgga
acagtacaacttggagattttggaattgctagagttcttaatagtactgtagagctggct
cgaacttgcatagggaccccatactacttgtcacctgaaatctgtgaaaacaaaccttac
aataataaaagtgacatttgggctctggggtgtgtcctttatgagctgtgtacacttaaa
catgcttttgaagctggcagtatgaaaaacctggtactgaagataatatctggatctttt
ccacctgtgtctttgcattattcctatgatctccgcagtttggtgtctcagttatttaaa
agaaatcctagggatagaccatcagtcaactccatattggagaaaggttttatagccaaa
cgcattgaaaagtttctctctcctcagcttattgcagaagaattttgtctaaaaacattt
tcgaagtttggatcacagcctataccagctaaaagaccagcttcaggacaaaactcgatt
tctgttatgcctgctcagaaaattacaaagcctgccgctaaatatggaatacctttagca
tataagaaatatggagataaaaaattacacgaaaagaaaccactgcaaaaacataaacag
gcccatcaaactccagagaagagagtgaatactggagaagaaaggaggaaaatatctgag
gaagcagcaagaaagagaaggctggaatttattgaaaaagaaaagaaacaaaaggatcag
attattagtttaatgaaggctgaacaaatgaaaaggcaagaaaaggaaaggttggaaaga
ataaatagggccagggaacaaggatggagaaatgtgctaagtgctggtggaagtggtgaa
gtaaaggctccttttctgggcagtggagggactatagctccatcatctttttcttctcga
ggacagtatgaacattaccatgccatttttgaccaaatgcagcaacaaagagcagaagat
aatgaagctaaatggaaaagagaaatatatggtcgaggtcttccagaaagaggaattctg
cctggagttcgtccaggatttccttatggggctgcaggtcatcaccattttcctgatgct
gatgatattagaaaaactttgaaaagattgaaggcggtgtctaaacaagccaatgcaaac
aggcaaaaagggcagctagctgtagaaagagctaaacaagtagaagagttcctgcagcga
aaacgggaagctatgcagaataaagctcgagccgaaggacatatggtttatctggcaaga
ctgaggcaaataagactacagaatttcaatgagcgccaacagattaaagccaaacttcgt
ggtgaaaagaaagaagctaatcattctgaaggacaagaaggaagtgaagaggctgacatg
aggcgcaaaaaaatcgaatcactgaaggcccatgcaaatgcacgtgctgctgtactaaaa
gaacaactagaacgaaagagaaaggaggcttatgagagagaaaaaaaagtgtgggaagag
catttggtggctaaaggagttaagagttctgatgtttctccacctttgggacagcatgaa
acaggtggctctccatcaaagcaacagatgagatctgttatttctgtaacttcagctttg
aaagaagttggcgtggacagtagtttaactgatacccgggaaacttcagaagagatgcaa
aagaccaacaatgctatttcaagtaagcgagaaatacttcgtagattaaatgaaaatctt
aaagctcaagaagatgaaaaaggaaagcagaatctctctgatacttttgagataaatgtt
catgaagatgccaaagagcatgaaaaagaaaaatcagtttcatctgatcgcaagaagtgg
gaggcaggaggtcaacttgtgattcctctggatgagttaacactagatacatccttctct
acaactgaaagacatacagtgggagaagttattaaattaggtcctaatggatctccaaga
agagcctgggggaaaagtccgacagattctgttctaaagatacttggagaagctgaacta
caacttcagacagaactattagaaaatacaactattagaagtgagatttctcccgaaggg
gaaaagtacaaacccttaattactggagaaaaaaaagtacaatgtatttcacatgaaata
aacccatcagctattgttgattctcctgttgagacaaaaagtcccgagttcagtgaggca
tctccacagatgtcattgaaactggaaggaaatttagaagaacctgatgatttggaaaca
gaaattctacaagagccaagtggaacaaacaaagatgagagcttgccatgcactattact
gatgtgtggattagtgaggaaaaagaaacaaaggaaactcagtcggcagataggatcacc
attcaggaaaatgaagtttctgaagatggagtctcgagtactgtggaccaacttagtgac
attcatatagagcctggaaccaatgattctcagcactctaaatgtgatgtagataagtct
gtgcaaccggaaccatttttccataaggtggttcattctgaacacttgaacttagtccct
caagttcaatcagttcagtgttcaccagaagaatcctttgcatttcgatctcactcgcat
ttaccaccaaaaaataaaaacaagaattccttgctgattggactttcaactggtctgttt
gatgcaaacaacccaaagatgttaaggacatgttcacttccagatctctcaaagctgttc
agaacccttatggatgttcccaccgtaggagatgttcgtcaagacaatcttgaaatagat
gaaattgaagatgaaaacattaaagaaggaccttctgattctgaagacattgtgtttgaa
gaaactgacacagatttacaagagctgcaggcctcgatggaacagttacttagggaacaa
cctggtgaagaatacagtgaagaagaagagtcagtcttgaagaacagtgatgtggagcca
actgcaaatgggacagatgtggcagatgaagatgacaatcccagcagtgaaagtgccctg
aacgaagaatggcactcagataacagtgatggtgaaattgctagtgaatgtgaatgcgat
agtgtctttaaccatttagaggaactgagacttcatctggagcaggaaatgggctttgaa
aaattctttgaggtttatgagaaaataaaggctattcatgaagatgaagatgaaaatatt
gaaatttgttcaaaaatagttcaaaatattttgggaaatgaacatcagcatctttatgcc
aagattcttcatttagtcatggcagatggagcctaccaagaagataatgatgaataa

  All links  
Disease (4)   
   OMIM (4)   
Gene (22)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (45)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (43)   
DNA sequence (75)   
   RefSeq(nuc) (45)   
   GenBank (15)   
   EMBL (15)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (153)   

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