KEGG   Homo sapiens (human): 4751
Entry
4751              CDS       T01001                                 
Symbol
NEK2, HsPK21, NEK2A, NLK1, PPP1R111, RP67
Name
(RefSeq) serine/threonine-protein kinase Nek2 isoform 1
  KO
K20872  serine/threonine-protein kinase Nek2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4751 (NEK2)
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    4751 (NEK2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    4751 (NEK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     4751 (NEK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  NEK family
   4751 (NEK2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     4751 (NEK2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     4751 (NEK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 APH
Other DBs
NCBI-GeneID: 4751
NCBI-ProteinID: NP_002488
OMIM: 604043
HGNC: 7745
Ensembl: ENSP00000355966.4
UniProt: P51955
Structure
Position
1:complement(211658256..211675621)
AA seq 445 aa
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
NT seq 1338 nt   +upstreamnt  +downstreamnt
atgccttcccgggctgaggactatgaagtgttgtacaccattggcacaggctcctacggc
cgctgccagaagatccggaggaagagtgatggcaagatattagtttggaaagaacttgac
tatggctccatgacagaagctgagaaacagatgcttgtttctgaagtgaatttgcttcgt
gaactgaaacatccaaacatcgttcgttactatgatcggattattgaccggaccaataca
acactgtacattgtaatggaatattgtgaaggaggggatctggctagtgtaattacaaag
ggaaccaaggaaaggcaatacttagatgaagagtttgttcttcgagtgatgactcagttg
actctggccctgaaggaatgccacagacgaagtgatggtggtcataccgtattgcatcgg
gatctgaaaccagccaatgttttcctggatggcaagcaaaacgtcaagcttggagacttt
gggctagctagaatattaaaccatgacacgagttttgcaaaaacatttgttggcacacct
tattacatgtctcctgaacaaatgaatcgcatgtcctacaatgagaaatcagatatctgg
tcattgggctgcttgctgtatgagttatgtgcattaatgcctccatttacagcttttagc
cagaaagaactcgctgggaaaatcagagaaggcaaattcaggcgaattccataccgttac
tctgatgaattgaatgaaattattacgaggatgttaaacttaaaggattaccatcgacct
tctgttgaagaaattcttgagaaccctttaatagcagatttggttgcagacgagcaaaga
agaaatcttgagagaagagggcgacaattaggagagccagaaaaatcgcaggattccagc
cctgtattgagtgagctgaaactgaaggaaattcagttacaggagcgagagcgagctctc
aaagcaagagaagaaagattggagcagaaagaacaggagctttgtgttcgtgagagacta
gcagaggacaaactggctagagcagaaaatctgttgaagaactacagcttgctaaaggaa
cggaagttcctgtctctggcaagtaatccagaacttcttaatcttccatcctcagtaatt
aagaagaaagttcatttcagtggggaaagtaaagagaacatcatgaggagtgagaattct
gagagtcagctcacatctaagtccaagtgcaaggacctgaagaaaaggcttcacgctgcc
cagctgcgggctcaagccctgtcagatattgagaaaaattaccaactgaaaagcagacag
atcctgggcatgcgctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (17)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (35)   
   RefSeq(nuc) (3)   
   GenBank (16)   
   EMBL (16)   
3D Structure (30)   
   PDB (30)   
Protein domain (5)   
   Pfam (5)   
All databases (94)   

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