KEGG   Homo sapiens (human): 4771
Entry
4771              CDS       T01001                                 
Symbol
NF2, ACN, BANF, SCH, SWNV, merlin-1
Name
(RefSeq) NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
  KO
K16684  merlin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04390  Hippo signaling pathway
hsa04392  Hippo signaling pathway - multiple species
hsa04530  Tight junction
Disease
H00015  Malignant pleural mesothelioma
H01438  Neurofibromatosis type 2
H01556  Meningioma
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    4771 (NF2)
   04392 Hippo signaling pathway - multiple species
    4771 (NF2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    4771 (NF2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4771 (NF2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Ezrin/Radixin/Moesin
     4771 (NF2)
SSDB
Motif
Pfam: FERM_M ERM_C FERM_C ERM_helical FERM_N
Other DBs
NCBI-GeneID: 4771
NCBI-ProteinID: NP_000259
OMIM: 607379
HGNC: 7773
Ensembl: ENSG00000186575
UniProt: P35240
Structure
Position
22:29603556..29698600
AA seq 595 aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL
NT seq 1788 nt   +upstreamnt  +downstreamnt
atggccggggccatcgcttcccgcatgagcttcagctctctcaagaggaagcaacccaag
acgttcaccgtgaggatcgtcaccatggacgccgagatggagttcaattgcgagatgaag
tggaaagggaaggacctctttgatttggtgtgccggactctggggctccgagaaacctgg
ttctttggactgcagtacacaatcaaggacacagtggcctggctcaaaatggacaagaag
gtactggatcatgatgtttcaaaggaagaaccagtcacctttcacttcttggccaaattt
tatcctgagaatgctgaagaggagctggttcaggagatcacacaacatttattcttctta
caggtaaagaagcagattttagatgaaaagatctactgccctcctgaggcttctgtgctc
ctggcttcttacgccgtccaggccaagtatggtgactacgaccccagtgttcacaagcgg
ggatttttggcccaagaggaattgcttccaaaaagggtaataaatctgtatcagatgact
ccggaaatgtgggaggagagaattactgcttggtacgcagagcaccgaggccgagccagg
gatgaagctgaaatggaatatctgaagatagctcaggacctggagatgtacggtgtgaac
tactttgcaatccggaataaaaagggcacagagctgctgcttggagtggatgccctgggg
cttcacatttatgaccctgagaacagactgacccccaagatctccttcccgtggaatgaa
atccgaaacatctcgtacagtgacaaggagtttactattaaaccactggataagaaaatt
gatgtcttcaagtttaactcctcaaagcttcgtgttaataagctgattctccagctatgt
atcgggaaccatgatctatttatgaggagaaggaaagccgattctttggaagttcagcag
atgaaagcccaggccagggaggagaaggctagaaagcagatggagcggcagcgcctcgct
cgagagaagcagatgagggaggaggctgaacgcacgagggatgagttggagaggaggctg
ctgcagatgaaagaagaagcaacaatggccaacgaagcactgatgcggtctgaggagaca
gctgacctgttggctgaaaaggcccagatcaccgaggaggaggcaaaacttctggcccag
aaggccgcagaggctgagcaggaaatgcagcgcatcaaggccacagcgattcgcacggag
gaggagaagcgcctgatggagcagaaggtgctggaagccgaggtgctggcactgaagatg
gctgaggagtcagagaggagggccaaagaggcagatcagctgaagcaggacctgcaggaa
gcacgcgaggcggagcgaagagccaagcagaagctcctggagattgccaccaagcccacg
tacccgcccatgaacccaattccagcaccgttgcctcctgacataccaagcttcaacctc
attggtgacagcctgtctttcgacttcaaagatactgacatgaagcggctttccatggag
atagagaaagaaaaagtggaatacatggaaaagagcaagcatctgcaggagcagctcaat
gaactcaagacagaaatcgaggccttgaaactgaaagagagggagacagctctggatatt
ctgcacaatgagaactccgacaggggtggcagcagcaagcacaataccattaaaaagctc
accttgcagagcgccaagtcccgagtggccttctttgaagagctctag

  All links  
Disease (3)   
   OMIM (3)   
Gene (15)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (29)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (27)   
DNA sequence (116)   
   RefSeq(nuc) (32)   
   GenBank (42)   
   EMBL (42)   
3D Structure (6)   
   PDB (6)   
Protein domain (5)   
   Pfam (5)   
All databases (174)   

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