KEGG   Homo sapiens (human): 4772Help
Entry
4772              CDS       T01001                                 

Gene name
NFATC1, NF-ATC, NF-ATc1.2, NFAT2, NFATc
Definition
(RefSeq) nuclear factor of activated T cells 1
  KO
K04446  nuclear factor of activated T-cells, cytoplasmic 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04380  Osteoclast differentiation
hsa04625  C-type lectin receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05321  Inflammatory bowel disease (IBD)
Network
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00172  KSHV K15 to PLCG-calcineurin signaling pathway
N00180  KSHV K1 to PLCG-calcineurin signaling pathway
N00401  CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
N00402  HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway
N00432  HIV gp120 to CXCR4-GNAQ-PLCB/G-calcineurin
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4772 (NFATC1)
   04310 Wnt signaling pathway
    4772 (NFATC1)
   04024 cAMP signaling pathway
    4772 (NFATC1)
   04022 cGMP - PKG signaling pathway
    4772 (NFATC1)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    4772 (NFATC1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    4772 (NFATC1)
   04650 Natural killer cell mediated cytotoxicity
    4772 (NFATC1)
   04660 T cell receptor signaling pathway
    4772 (NFATC1)
   04658 Th1 and Th2 cell differentiation
    4772 (NFATC1)
   04659 Th17 cell differentiation
    4772 (NFATC1)
   04662 B cell receptor signaling pathway
    4772 (NFATC1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    4772 (NFATC1)
  09158 Development
   04380 Osteoclast differentiation
    4772 (NFATC1)
 09160 Human Diseases
  09162 Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    4772 (NFATC1)
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    4772 (NFATC1)
  09167 Infectious diseases
   05166 HTLV-I infection
    4772 (NFATC1)
   05161 Hepatitis B
    4772 (NFATC1)
   05163 Human cytomegalovirus infection
    4772 (NFATC1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    4772 (NFATC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4772 (NFATC1)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) NF-AT
    4772 (NFATC1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RHD_DNA_bind RHD_dimer TIG
Motif
Other DBs
NCBI-GeneID: 4772
NCBI-ProteinID: NP_001265598
OMIM: 600489
HGNC: 7775
Ensembl: ENSG00000131196
Vega: OTTHUMG00000132897
Pharos: O95644(Tbio)
UniProt: O95644
Structure
PDB: 

Position
18q23
AA seq 943 aa AA seqDB search
MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPT
AHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRI
EITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSR
SCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPST
SPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSW
LGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSP
PPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLP
SHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGT
ADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLR
NSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEK
QSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEI
PPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQ
GLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGV
ASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEH
SLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHE
DGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
NT seq 2832 nt NT seq  +upstreamnt  +downstreamnt
atgccaagcaccagctttccagtcccttccaagtttccacttggccctgcggctgcggtc
ttcgggagaggagaaactttggggcccgcgccgcgcgccggcggcaccatgaagtcagcg
gaggaagaacactatggctatgcatcctccaacgtcagccccgccctgccgctccccacg
gcgcactccaccctgccggccccgtgccacaaccttcagacctccacaccgggcatcatc
ccgccggcggatcacccctcggggtacggagcagctttggacggtgggcccgcgggctac
ttcctctcctccggccacaccaggcctgatggggcccctgccctggagagtcctcgcatc
gagataacctcgtgcttgggcctgtaccacaacaataaccagtttttccacgatgtggag
gtggaagacgtcctccctagctccaaacggtccccctccacggccacgctgagtctgccc
agcctggaggcctacagagacccctcgtgcctgagcccggccagcagcctgtcctcccgg
agctgcaactcagaggcctcctcctacgagtccaactactcgtacccgtacgcgtccccc
cagacgtcgccatggcagtctccctgcgtgtctcccaagaccacggaccccgaggagggc
tttccccgcgggctgggggcctgcacactgctgggttccccgcggcactccccctccacc
tcgccccgcgccagcgtcactgaggagagctggctgggtgcccgctcctccagacccgcg
tccccttgcaacaagaggaagtacagcctcaacggccggcagccgccctactcaccccac
cactcgcccacgccgtccccgcacggctccccgcgggtcagcgtgaccgacgactcgtgg
ttgggcaacaccacccagtacaccagctcggccatcgtggccgccatcaacgcgctgacc
accgacagcagcctggacctgggagatggcgtccctgtcaagtcccgcaagaccaccctg
gagcagccgccctcagtggcgctcaaggtggagcccgtcggggaggacctgggcagcccc
ccgcccccggccgacttcgcgcccgaagactactcctctttccagcacatcaggaagggc
ggcttctgcgaccagtacctggcggtgccgcagcacccctaccagtgggcgaagcccaag
cccctgtcccctacgtcctacatgagcccgaccctgcccgccctggactggcagctgccg
tcccactcaggcccgtatgagcttcggattgaggtgcagcccaagtcccaccaccgagcc
cactacgagacggagggcagccggggggccgtgaaggcgtcggccggaggacaccccatc
gtgcagctgcatggctacttggagaatgagccgctgatgctgcagcttttcattgggacg
gcggacgaccgcctgctgcgcccgcacgccttctaccaggtgcaccgcatcacagggaag
accgtgtccaccaccagccacgaggccatcctctccaacaccaaagtcctggagatccca
ctcctgccggagaacagcatgcgagccgtcattgactgtgccggaatcctgaaactcaga
aactccgacattgaacttcggaaaggagagacggacatcgggaggaagaacacacgggta
cggctggtgttccgcgttcacgtcccgcaacccagcggccgcacgctgtccctgcaggtg
gcctccaaccccatcgaatgctcccagcgctcagctcaggagctgcctctggtggagaag
cagagcacggacagctatccggtcgtgggcgggaagaagatggtcctgtctggccacaac
ttcctgcaggactccaaggtcattttcgtggagaaagccccagatggccaccatgtctgg
gagatggaagcgaaaactgaccgggacctgtgcaagccgaattctctggtggttgagatc
ccgccatttcggaatcagaggataaccagccccgttcacgtcagtttctacgtctgcaac
gggaagagaaagcgaagccagtaccagcgtttcacctaccttcccgccaacgttccaatt
ataaaaacagaacccactgatgattatgagcctgctccaacctgtggaccggtgagccag
gggttaagtcctctcccaagaccatactacagccagcagctcgcgatgccacccgacccc
agctcctgcctcgtggccggcttcccgccctgtccgcagagaagcaccctgatgccagcg
gcccctggcgtgagccccaagctccacgacctttctcccgctgcctacaccaagggcgtt
gccagcccgggccactgtcacctcggactcccgcagccggccggagaggcccccgccgtc
caggacgtgcccaggccagtggccacgcaccccggctcgcccgggcagccacccccggcc
ctgctgccacagcaggtgagtgcgcctccaagcagtagctgcccccctggtctcgaacac
tcgctctgccccagcagcccctctcctccactcccgcctgccacccaagagccgacctgc
ctgcagccctgcagcccagcgtgcccgcccgccacgggccgcccgcagcacctgccgtcc
acggtccgcagggacgagtctccgactgccgggccacggctgctgccagaggtgcatgag
gacggtagtcctaatttggcccctattcctgtaacggtcaagcgagagcctgaagagttg
gaccagttgtacctggatgacgtaaatgaaataatacgaaatgacctctccagcacgagc
acccactcctag

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