KEGG   Homo sapiens (human): 4860
Entry
4860              CDS       T01001                                 

Gene name
PNP, NP, PRO1837, PUNP
Definition
(RefSeq) purine nucleoside phosphorylase
  KO
K03783  purine-nucleoside phosphorylase [EC:2.4.2.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
Disease
H00093  Combined immunodeficiency
Drug target
Forodesine (DG01392): D04245<JP> D06596
Peldesine: D05396
Ulodesine (DG01881): D10431 D10432
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    4860 (PNP)
   00240 Pyrimidine metabolism
    4860 (PNP)
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    4860 (PNP)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.1  purine-nucleoside phosphorylase
     4860 (PNP)
SSDB
Motif
Pfam: PNP_UDP_1
Other DBs
NCBI-GeneID: 4860
NCBI-ProteinID: NP_000261
OMIM: 164050
HGNC: 7892
Ensembl: ENSG00000198805
Vega: OTTHUMG00000029546
Pharos: P00491(Tchem)
UniProt: P00491 V9HWH6
Structure
PDB: 

Position
14q11.2
AA seq 289 aa
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
NT seq 870 nt   +upstreamnt  +downstreamnt
atggagaacggatacacctatgaagattataagaacactgcagaatggcttctgtctcac
actaagcaccgacctcaagttgcaataatctgtggttctggattaggaggtctgactgat
aaattaactcaggcccagatctttgactacggtgaaatccccaactttccccgaagtaca
gtgccaggtcatgctggccgactggtgtttgggttcctgaatggcagggcctgtgtgatg
atgcagggcaggttccacatgtatgaagggtacccactctggaaggtgacattcccagtg
agggttttccaccttctgggtgtggacaccctggtagtcaccaatgcagcaggagggctg
aaccccaagtttgaggttggagatatcatgctgatccgtgaccatatcaacctacctggt
ttcagtggtcagaaccctctcagagggcccaatgatgaaaggtttggagatcgtttccct
gccatgtctgatgcctacgaccggactatgaggcagagggctctcagtacctggaaacaa
atgggggagcaacgtgagctacaggaaggcacctatgtgatggtggcaggccccagcttt
gagactgtggcagaatgtcgtgtgctgcagaagctgggagcagacgctgttggcatgagt
acagtaccagaagttatcgttgcacggcactgtggacttcgagtctttggcttctcactc
atcactaacaaggtcatcatggattatgaaagcctggagaaggccaaccatgaagaagtc
ttagcagctggcaaacaagctgcacagaaattggaacagtttgtctccattcttatggcc
agcattccactccctgacaaagccagttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (5)   
   KEGG DRUG (5)   
Chemical substance (24)   
   KEGG COMPOUND (24)   
Chemical reaction (13)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
Protein domain (1)   
   Pfam (1)   
All databases (99)   

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