KEGG   Homo sapiens (human): 4916
Entry
4916              CDS       T01001                                 
Symbol
NTRK3, GP145-TrkC, TRKC, gp145(trkC)
Name
(RefSeq) neurotrophic receptor tyrosine kinase 3
  KO
K05101  neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa05230  Central carbon metabolism in cancer
Network
nt06528  Calcium signaling
  Element
N01641  RTK-PLCG-ITPR signaling pathway
Disease
H00043  Neuroblastoma
H01508  Salivary gland cancer
Drug target
Entrectinib: D10926<JP/US>
Larotrectinib (DG02923): D11137 D11138<JP/US>
Paltimatrectinib: D12646
Repotrectinib: D11454<JP/US>
Taletrectinib (DG03226): D12363 D12364
Zurletrectinib: D12432
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    4916 (NTRK3)
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    4916 (NTRK3)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    4916 (NTRK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4916 (NTRK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     4916 (NTRK3)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   4916 (NTRK3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase I-set LRRCT_2 ig Ig_3 LRR_8 Ig_2 C2-set_2 LRRNT LRR_4 LRR_5 TrkA_TMD Haspin_kinase LRR_NXF1-5 LRR_6 C2-set_3
Other DBs
NCBI-GeneID: 4916
NCBI-ProteinID: NP_001012338
OMIM: 191316
HGNC: 8033
Ensembl: ENSG00000140538
UniProt: Q16288 X5D2R1
Structure
Position
15:complement(87859751..88256739)
AA seq 839 aa
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
NT seq 2520 nt   +upstreamnt  +downstreamnt
atggatgtctctctttgcccagccaagtgtagtttctggcggattttcttgctgggaagc
gtctggctggactatgtgggctccgtgctggcttgccctgcaaattgtgtctgcagcaag
actgagatcaattgccggcggccggacgatgggaacctcttccccctcctggaagggcag
gattcagggaacagcaatgggaacgccagtatcaacatcacggacatctcaaggaatatc
acttccatacacatagagaactggcgcagtcttcacacgctcaacgccgtggacatggag
ctctacaccggacttcaaaagctgaccatcaagaactcaggacttcggagcattcagccc
agagcctttgccaagaacccccatttgcgttatataaacctgtcaagtaaccggctcacc
acactctcgtggcagctcttccagacgctgagtcttcgggaattgcagttggagcagaac
tttttcaactgcagctgtgacatccgctggatgcagctctggcaggagcagggggaggcc
aagctcaacagccagaacctctactgcatcaacgctgatggctcccagcttcctctcttc
cgcatgaacatcagtcagtgtgaccttcctgagatcagcgtgagccacgtcaacctgacc
gtacgagagggtgacaacgctgttatcacttgcaatggctctggatcaccccttcctgat
gtggactggatagtcactgggctgcagtccatcaacactcaccagaccaatctgaactgg
accaatgttcatgccatcaacttgacgctggtgaatgtgacgagtgaggacaatggcttc
accctgacgtgcattgcagagaacgtggtgggcatgagcaatgccagtgttgccctcact
gtctactatcccccacgtgtggtgagcctggaggagcctgagctgcgcctggagcactgc
atcgagtttgtggtgcgtggcaaccccccaccaacgctgcactggctgcacaatgggcag
cctctgcgggagtccaagatcatccatgtggaatactaccaagagggagagatttccgag
ggctgcctgctcttcaacaagcccacccactacaacaatggcaactataccctcattgcc
aaaaacccactgggcacagccaaccagaccatcaatggccacttcctcaaggagcccttt
ccagagagcacggataactttatcttgtttgacgaagtgagtcccacacctcctatcact
gtgacccacaaaccagaagaagacacttttggggtatccatagcagttggacttgctgct
tttgcctgtgtcctgttggtggttctcttcgtcatgatcaacaaatatggtcgacggtcc
aaatttggaatgaagggtcccgtggctgtcatcagtggtgaggaggactcagccagccca
ctgcaccacatcaaccacggcatcaccacgccctcgtcactggatgccgggcccgacact
gtggtcattggcatgactcgcatccctgtcattgagaacccccagtacttccgtcaggga
cacaactgccacaagccggacacgtatgtgcagcacattaagaggagagacatcgtgctg
aagcgagaactgggtgagggagcctttggaaaggtcttcctggccgagtgctacaacctc
agcccgaccaaggacaagatgcttgtggctgtgaaggccctgaaggatcccaccctggct
gcccggaaggatttccagagggaggccgagctgctcaccaacctgcagcatgagcacatt
gtcaagttctatggagtgtgcggcgatggggaccccctcatcatggtctttgaatacatg
aagcatggagacctgaataagttcctcagggcccatgggccagatgcaatgatccttgtg
gatggacagccacgccaggccaagggtgagctggggctctcccaaatgctccacattgcc
agtcagatcgcctcgggtatggtgtacctggcctcccagcactttgtgcaccgagacctg
gccaccaggaactgcctggttggagcgaatctgctagtgaagattggggacttcggcatg
tccagagatgtctacagcacggattattacaggctctttaatccatctggaaatgatttt
tgtatatggtgtgaggtgggaggacacaccatgctccccattcgctggatgcctcctgaa
agcatcatgtaccggaagttcactacagagagtgatgtatggagcttcggggtgatcctc
tgggagatcttcacctatggaaagcagccatggttccaactctcaaacacggaggtcatt
gagtgcattacccaaggtcgtgttttggagcggccccgagtctgccccaaagaggtgtac
gatgtcatgctggggtgctggcagagggaaccacagcagcggttgaacatcaaggagatc
tacaaaatcctccatgctttggggaaggccaccccaatctacctggacattcttggctag

  All links  
Disease (1)   
   OMIM (1)   
Gene (22)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (54)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (51)   
DNA sequence (125)   
   RefSeq(nuc) (57)   
   GenBank (34)   
   EMBL (34)   
3D Structure (5)   
   PDB (5)   
Protein domain (17)   
   Pfam (17)   
All databases (224)   

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