KEGG   Homo sapiens (human): 4986Help
Entry
4986              CDS       T01001                                 

Gene name
OPRK1, K-OR-1, KOR, KOR-1, OPRK
Definition
(RefSeq) opioid receptor kappa 1
  KO
K04214  kappa-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Buprenorphine (DG00820): D00836 D07132
Butorphanol (DG00821): D00837 D03197
Cyclazocine: D03618
Dezocine: D00838
Difelikefalin (DG02914): D10890 D11111
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403
Enadoline hydrochloride: D06395
Eptazocine (DG01340): D01879 D07904
Etorphine: D07937
Ketazocine: D04649
Ketobemidone (DG00815): D08100 D08101
Levallorphan tartrate: D02238
Loperamide (DG00092): D00729 D08144
Loperamide oxide (DG00092): D07113
Nalbuphine (DG00822): D00843 D08246
Nalfurafine: D06405
Nalmefene (DG00998): D02104 D05111 D10812
Nalorphine (DG01151): D08247 D08248
Naloxone (DG01155): D01340 D08249 D11620
Naltrexone (DG00997): D02095 D05113
Oxilorphan: D05299
Oxycodone (DG00813): D00847 D03783 D05312 D05462
Pentazocine (DG00819): D00498 D02111 D02227
Proxorphan tartrate: D05646
Quadazocine mesylate: D05667
Spiradoline mesylate: D05907
Tonazocine mesylate: D06189
Trimebutine (DG00031): D01500 D08639
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4986 (OPRK1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4986 (OPRK1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4986 (OPRK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 4986
NCBI-ProteinID: NP_000903
OMIM: 165196
HGNC: 8154
Ensembl: ENSG00000082556
Vega: OTTHUMG00000164276
Pharos: P41145(Tclin)
UniProt: P41145
Position
8q11.23
AA seq 380 aa AA seqDB search
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
NT seq 1143 nt NT seq  +upstreamnt  +downstreamnt
atggactccccgatccagatcttccgcggggagccgggccctacctgcgccccgagcgcc
tgcctgccccccaacagcagcgcctggtttcccggctgggccgagcccgacagcaacggc
agcgccggctcggaggacgcgcagctggagcccgcgcacatctccccggccatcccggtc
atcatcacggcggtctactccgtagtgttcgtcgtgggcttggtgggcaactcgctggtc
atgttcgtgatcatccgatacacaaagatgaagacagcaaccaacatttacatatttaac
ctggctttggcagatgctttagttactacaaccatgccctttcagagtacggtctacttg
atgaattcctggccttttggggatgtgctgtgcaagatagtaatttccattgattactac
aacatgttcaccagcatcttcaccttgaccatgatgagcgtggaccgctacattgccgtg
tgccaccccgtgaaggctttggacttccgcacacccttgaaggcaaagatcatcaatatc
tgcatctggctgctgtcgtcatctgttggcatctctgcaatagtccttggaggcaccaaa
gtcagggaagacgtcgatgtcattgagtgctccttgcagttcccagatgatgactactcc
tggtgggacctcttcatgaagatctgcgtcttcatctttgccttcgtgatccctgtcctc
atcatcatcgtctgctacaccctgatgatcctgcgtctcaagagcgtccggctcctttct
ggctcccgagagaaagatcgcaacctgcgtaggatcaccagactggtcctggtggtggtg
gcagtcttcgtcgtctgctggactcccattcacatattcatcctggtggaggctctgggg
agcacctcccacagcacagctgctctctccagctattacttctgcatcgccttaggctat
accaacagtagcctgaatcccattctctacgcctttcttgatgaaaacttcaagcggtgt
ttccgggacttctgctttccactgaagatgaggatggagcggcagagcactagcagagtc
cgaaatacagttcaggatcctgcttacctgagggacatcgatgggatgaataaaccagta
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (50)   
   KEGG DRUG (50)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
Protein domain (5)   
   Pfam (5)   
All databases (109)   

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