KEGG   Homo sapiens (human): 4986
Entry
4986              CDS       T01001                                 
Symbol
OPRK1, K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK
Name
(RefSeq) opioid receptor kappa 1
  KO
K04214  kappa-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
Drug target
Acetorphine: D12700
Aticaprant: D11831
Buprenorphine (DG00820): D00836<JP/US> D07132<JP/US>
Butorphanol (DG00821): D00837<US> D03197
Cyclazocine: D03618
Dezocine: D00838
Difelikefalin (DG02914): D10890<JP/US> D11111
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403<US>
Enadoline hydrochloride: D06395
Eptazocine (DG01340): D01879 D07904
Etorphine: D07937
Icalcaprant: D13002
Ketazocine: D04649
Ketobemidone (DG00815): D08100 D08101
Levallorphan tartrate: D02238<JP>
Loperamide (DG00092): D00729<JP/US> D08144
Loperamide oxide (DG00092): D07113
Nalbuphine (DG00822): D00843<US> D08246
Nalfurafine: D06405<JP>
Nalmefene (DG00998): D02104<US> D05111 D10812<JP>
Nalorphine (DG01151): D08247 D08248
Naloxone (DG01155): D01340<JP/US> D08249 D11620<US>
Naltrexone (DG00997): D02095<US> D05113<US>
Navacaprant (DG03305): D12869 D12870
Oxilorphan: D05299
Oxycodone (DG00813): D00847<US> D03783 D05312<US> D05462<JP>
Pentazocine (DG00819): D00498<JP> D02111 D02227<JP>
Proxorphan tartrate: D05646
Quadazocine mesylate: D05667
Spiradoline mesylate: D05907
Tonazocine mesylate: D06189
Trimebutine (DG00031): D01500<JP> D08639
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4986 (OPRK1)
   04082 Neuroactive ligand signaling
    4986 (OPRK1)
   04081 Hormone signaling
    4986 (OPRK1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4986 (OPRK1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4986 (OPRK1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx V1R
Other DBs
NCBI-GeneID: 4986
NCBI-ProteinID: NP_000903
OMIM: 165196
HGNC: 8154
Ensembl: ENSG00000082556
UniProt: P41145
Structure
Position
8:complement(53225724..53251637)
AA seq 380 aa
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
NT seq 1143 nt   +upstreamnt  +downstreamnt
atggactccccgatccagatcttccgcggggagccgggccctacctgcgccccgagcgcc
tgcctgccccccaacagcagcgcctggtttcccggctgggccgagcccgacagcaacggc
agcgccggctcggaggacgcgcagctggagcccgcgcacatctccccggccatcccggtc
atcatcacggcggtctactccgtagtgttcgtcgtgggcttggtgggcaactcgctggtc
atgttcgtgatcatccgatacacaaagatgaagacagcaaccaacatttacatatttaac
ctggctttggcagatgctttagttactacaaccatgccctttcagagtacggtctacttg
atgaattcctggccttttggggatgtgctgtgcaagatagtaatttccattgattactac
aacatgttcaccagcatcttcaccttgaccatgatgagcgtggaccgctacattgccgtg
tgccaccccgtgaaggctttggacttccgcacacccttgaaggcaaagatcatcaatatc
tgcatctggctgctgtcgtcatctgttggcatctctgcaatagtccttggaggcaccaaa
gtcagggaagacgtcgatgtcattgagtgctccttgcagttcccagatgatgactactcc
tggtgggacctcttcatgaagatctgcgtcttcatctttgccttcgtgatccctgtcctc
atcatcatcgtctgctacaccctgatgatcctgcgtctcaagagcgtccggctcctttct
ggctcccgagagaaagatcgcaacctgcgtaggatcaccagactggtcctggtggtggtg
gcagtcttcgtcgtctgctggactcccattcacatattcatcctggtggaggctctgggg
agcacctcccacagcacagctgctctctccagctattacttctgcatcgccttaggctat
accaacagtagcctgaatcccattctctacgcctttcttgatgaaaacttcaagcggtgt
ttccgggacttctgctttccactgaagatgaggatggagcggcagagcactagcagagtc
cgaaatacagttcaggatcctgcttacctgagggacatcgatgggatgaataaaccagta
tga

  All links  
Disease (1)   
   OMIM (1)   
Gene (8)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
3D Structure (23)   
   PDB (23)   
Protein domain (5)   
   Pfam (5)   
All databases (81)   

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