KEGG   Homo sapiens (human): 4986
Entry
4986              CDS       T01001                                 

Gene name
OPRK1, K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK
Definition
(RefSeq) opioid receptor kappa 1
  KO
K04214  kappa-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Aticaprant: D11831
Buprenorphine (DG00820): D00836<JP/US> D07132<JP/US>
Butorphanol (DG00821): D00837<US> D03197
Cyclazocine: D03618
Dezocine: D00838
Difelikefalin (DG02914): D10890 D11111
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403<US>
Enadoline hydrochloride: D06395
Eptazocine (DG01340): D01879<JP> D07904
Etorphine: D07937
Ketazocine: D04649
Ketobemidone (DG00815): D08100 D08101
Levallorphan tartrate: D02238<JP>
Loperamide (DG00092): D00729<JP/US> D08144
Loperamide oxide (DG00092): D07113
Nalbuphine (DG00822): D00843<US> D08246
Nalfurafine: D06405<JP>
Nalmefene (DG00998): D02104 D05111 D10812<JP>
Nalorphine (DG01151): D08247 D08248
Naloxone (DG01155): D01340<JP/US> D08249 D11620<US>
Naltrexone (DG00997): D02095<US> D05113<US>
Oxilorphan: D05299
Oxycodone (DG00813): D00847<US> D03783 D05312 D05462<JP>
Pentazocine (DG00819): D00498<JP> D02111 D02227<JP>
Proxorphan tartrate: D05646
Quadazocine mesylate: D05667
Spiradoline mesylate: D05907
Tonazocine mesylate: D06189
Trimebutine (DG00031): D01500<JP> D08639
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4986 (OPRK1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4986 (OPRK1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4986 (OPRK1)
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 4986
NCBI-ProteinID: NP_000903
OMIM: 165196
HGNC: 8154
Ensembl: ENSG00000082556
Vega: OTTHUMG00000164276
Pharos: P41145(Tclin)
UniProt: P41145
Position
8q11.23
AA seq 380 aa
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
NT seq 1143 nt   +upstreamnt  +downstreamnt
atggactccccgatccagatcttccgcggggagccgggccctacctgcgccccgagcgcc
tgcctgccccccaacagcagcgcctggtttcccggctgggccgagcccgacagcaacggc
agcgccggctcggaggacgcgcagctggagcccgcgcacatctccccggccatcccggtc
atcatcacggcggtctactccgtagtgttcgtcgtgggcttggtgggcaactcgctggtc
atgttcgtgatcatccgatacacaaagatgaagacagcaaccaacatttacatatttaac
ctggctttggcagatgctttagttactacaaccatgccctttcagagtacggtctacttg
atgaattcctggccttttggggatgtgctgtgcaagatagtaatttccattgattactac
aacatgttcaccagcatcttcaccttgaccatgatgagcgtggaccgctacattgccgtg
tgccaccccgtgaaggctttggacttccgcacacccttgaaggcaaagatcatcaatatc
tgcatctggctgctgtcgtcatctgttggcatctctgcaatagtccttggaggcaccaaa
gtcagggaagacgtcgatgtcattgagtgctccttgcagttcccagatgatgactactcc
tggtgggacctcttcatgaagatctgcgtcttcatctttgccttcgtgatccctgtcctc
atcatcatcgtctgctacaccctgatgatcctgcgtctcaagagcgtccggctcctttct
ggctcccgagagaaagatcgcaacctgcgtaggatcaccagactggtcctggtggtggtg
gcagtcttcgtcgtctgctggactcccattcacatattcatcctggtggaggctctgggg
agcacctcccacagcacagctgctctctccagctattacttctgcatcgccttaggctat
accaacagtagcctgaatcccattctctacgcctttcttgatgaaaacttcaagcggtgt
ttccgggacttctgctttccactgaagatgaggatggagcggcagagcactagcagagtc
cgaaatacagttcaggatcctgcttacctgagggacatcgatgggatgaataaaccagta
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (51)   
   KEGG DRUG (51)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
Protein domain (4)   
   Pfam (4)   
All databases (115)   

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