KEGG   Homo sapiens (human): 4988
Entry
4988              CDS       T01001                                 
Symbol
OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Name
(RefSeq) opioid receptor mu 1
  KO
K04215  mu-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
hsa04915  Estrogen signaling pathway
hsa05032  Morphine addiction
Drug target
Acetorphine: D12700
Acetyldihydrocodeine: D07557
Alfentanil (DG00792): D00835 D07122
Allylprodine: D12662
Alphacetylmethadol: D12660
Alphameprodine: D12666
Alphamethadol: D12674
Alphaprodine: D12678
Alvimopan: D02878<US>
Anileridine (DG00794): D02941 D02942
Asalhydromorphone (DG02967): D11291 D11292
Axelopran (DG01857): D10690 D10740
Benzethidine: D12685
Benzhydrocodone (DG01850): D10612 D10692
Betacetylmethadol: D12661
Betameprodine: D12667
Betamethadol: D12675
Betaprodine: D12679
Bevenopran: D10349
Brifentanil hydrochloride: D03156
Buprenorphine (DG00820): D00836<JP/US> D07132<JP/US>
Butorphanol (DG00821): D00837<US> D03197
Carfentanil (DG01339): D03405 D07620
Cebranopadol: D10436
Clonitazene: D12668
Codeine (DG01076): D00195 D02101<JP> D03579 D03580<US> D07740
Cyclazocine: D03618
Dextropropoxyphene (DG00818): D00482<US> D05632 D07809
Dezocine: D00838
Diamorphine (DG01003): D07286 D07810
Diampromide: D12694
Difenoxin (DG03054): D03809 D11583
Dihydrocodeine (DG00814): D01481<JP> D03825 D07831 D07832
Diphenoxylate (DG00090): D03860 D07861
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403<US>
Ethoheptazine citrate: D01435
Ethylmorphine (DG01074): D02205 D07929
Etonitazene: D12669
Etorphine: D07937
Etoxeridine: D12680
Fentanyl (DG00791): D00320<JP/US> D01399<JP/US> D10811
Furethidine: D12682
Hydrocodone (DG01075): D03725<US> D04461 D08045 D08046
Hydromorphinol: D12686
Hydromorphone (DG00811): D00839<JP/US> D08047
Hydroxypethidine: D12681
Isomethadone: D12676
Ketobemidone (DG00815): D08100 D08101
Levacetylmethadol (DG01000): D00840 D04716
Levallorphan tartrate: D02238<JP>
Levomethadone (DG01002): D08121 D08122
Levomethorphan: D12696
Levophenacylmorphan: D12687
Levorphanol (DG01341): D00841<US> D08123
Lofentanil oxalate: D04764
Loperamide (DG00092): D00729<JP/US> D08144
Loperamide oxide (DG00092): D07113
Meptazinol (DG00825): D04924 D08182
Methadone (DG00999): D02102<JP/US> D08195
Methadyl acetate: D04973
Methyldesorphine: D12691
Methyldihydromorphine: D12689
Methylnaltrexone bromide: D06618<US>
Methylsamidorphan (DG01830): D10371 D10648
Metopon: D12690
Mirfentanil hydrochloride: D05048
Morpheridin: D12697
Morphine (DG00810): D00842<JP/US> D02271<JP> D08233 D08234
Nalbuphine (DG00822): D00843<US> D08246
Naldemedine (DG01342): D10188 D10478<JP/US>
Nalmefene (DG00998): D02104<US> D05111 D10812<JP>
Nalorphine (DG01151): D08247 D08248
Naloxegol (DG00078): D10375<US> D10479
Naloxone (DG01155): D01340<JP/US> D08249 D11620<US>
Naltrexone (DG00997): D02095<US> D05113<US>
Nicomorphine (DG00812): D07285 D08273
Norlevorphanol: D12692
Ocfentanil hydrochloride: D05217
Oliceridine: D11214<US>
Oxycodegol (DG03013): D11424 D11425
Oxycodone (DG00813): D00847<US> D03783 D05312<US> D05462<JP>
Oxymorphone (DG01343): D00844<US> D08323
Pentazocine (DG00819): D00498<JP> D02111 D02227<JP>
Pethidine (DG00816): D01383<JP/US> D08343
Phenampromide: D12693
Phenomorphan: D12688
Pholcodine: D07385
Piminodine: D12683
Properidine: D13025
Propiram fumarate: D05631
Quadazocine mesylate: D05667
Remifentanil (DG00795): D01177<JP/US> D08473
Samidorphan (DG01538): D10162 D10163
Sufentanil (DG00793): D00845<US> D05938
Tapentadol (DG00826): D06007 D10199<US>
Tilidine (DG00823): D06147 D08597
Tonazocine mesylate: D06189
Tramadol (DG00824): D01355<JP/US> D08623
Trefentanil hydrochloride: D06208
Trimebutine (DG00031): D01500<JP> D08639
Trimeperidine: D06268
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4988 (OPRM1)
   04082 Neuroactive ligand signaling
    4988 (OPRM1)
   04081 Hormone signaling
    4988 (OPRM1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    4988 (OPRM1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    4988 (OPRM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4988 (OPRM1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4988 (OPRM1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 4988
NCBI-ProteinID: NP_000905
OMIM: 600018
HGNC: 8156
Ensembl: ENSG00000112038
UniProt: P35372 G8XRH5
Structure
Position
6:154010496..154246867
AA seq 400 aa
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
NT seq 1203 nt   +upstreamnt  +downstreamnt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa

  All links  
Disease (1)   
   OMIM (1)   
Gene (11)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (30)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (27)   
DNA sequence (117)   
   RefSeq(nuc) (31)   
   GenBank (43)   
   EMBL (43)   
3D Structure (10)   
   PDB (10)   
Protein domain (3)   
   Pfam (3)   
All databases (172)   

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