KEGG   Homo sapiens (human): 4988Help
Entry
4988              CDS       T01001                                 

Gene name
OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Definition
(RefSeq) opioid receptor mu 1
  KO
K04215  mu-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04915  Estrogen signaling pathway
hsa05032  Morphine addiction
Disease
H01611  Alcohol dependence
Drug target
Acetyldihydrocodeine: D07557
Alfentanil (DG00792): D00835 D07122
Alvimopan: D02878
Anileridine (DG00794): D02941 D02942
Axelopran (DG01857): D10690 D10740
Benzhydrocodone (DG01850): D10612 D10692
Bevenopran: D10349
Brifentanil hydrochloride: D03156
Buprenorphine (DG00820): D00836 D07132
Butorphanol (DG00821): D00837 D03197
Carfentanil (DG01339): D03405 D07620
Cebranopadol: D10436
Codeine (DG01076): D00195 D02101 D03579 D03580 D07740
Cyclazocine: D03618
Dextropropoxyphene (DG00818): D00482 D05632 D07809
Dezocine: D00838
Diamorphine (DG01003): D07286 D07810
Difenoxin: D03809
Dihydrocodeine (DG00814): D01481 D03825 D07831 D07832
Diphenoxylate (DG00090): D03860 D07861
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403
Eptazocine (DG01340): D01879 D07904
Ethoheptazine citrate: D01435
Ethylmorphine (DG01074): D02205 D07929
Etorphine: D07937
Fentanyl (DG00791): D00320 D01399 D10811
Hydrocodone (DG01075): D03725 D04461 D08045 D08046
Hydromorphone (DG00811): D00839 D08047
Ketobemidone (DG00815): D08100 D08101
Levacetylmethadol (DG01000): D00840 D04716
Levallorphan tartrate: D02238
Levomethadone (DG01002): D08121 D08122
Levorphanol (DG01341): D00841 D08123
Lofentanil oxalate: D04764
Loperamide (DG00092): D00729 D08144
Loperamide oxide (DG00092): D07113
Meptazinol (DG00825): D04924 D08182
Methadone (DG00999): D02102 D08195
Methadyl acetate: D04973
Methylnaltrexone bromide: D06618
Methylsamidorphan (DG01830): D10371 D10648
Mirfentanil hydrochloride: D05048
Morphine (DG00810): D00842 D02271 D08233 D08234
Nalbuphine (DG00822): D00843 D08246
Naldemedine (DG01342): D10188 D10478
Nalmefene (DG00998): D02104 D05111 D10812
Nalorphine (DG01151): D08247 D08248
Naloxegol (DG00078): D10375 D10479
Naloxone (DG01155): D01340 D08249
Naltrexone (DG00997): D02095 D05113
Nicomorphine (DG00812): D07285 D08273
Ocfentanil hydrochloride: D05217
Oxycodone (DG00813): D00847 D03783 D05312 D05462
Oxymorphone (DG01343): D00844 D08323
Pentazocine (DG00819): D00498 D02111 D02227
Pethidine (DG00816): D01383 D08343
Pholcodine: D07385
Quadazocine mesylate: D05667
Remifentanil (DG00795): D01177 D08473
Samidorphan (DG01538): D10162 D10163
Sufentanil (DG00793): D00845 D05938
Tapentadol (DG00826): D06007 D10199
Tilidine (DG00823): D06147 D08597
Tramadol (DG00824): D01355 D08623
Trefentanil hydrochloride: D06208
Trimebutine (DG00031): D01500 D08639
Trimeperidine: D06268
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4988 (OPRM1)
 Organismal Systems
  Endocrine system
   04915 Estrogen signaling pathway
    4988 (OPRM1)
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    4988 (OPRM1)
G protein-coupled receptors [BR:hsa04030]
 Class A. Rhodopsin family
  Neuropeptide
   Opioid
    4988 (OPRM1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 4988
NCBI-ProteinID: NP_000905
OMIM: 600018
HGNC: 8156
Ensembl: ENSG00000112038
Vega: OTTHUMG00000015870
Pharos: P35372(Tclin)
UniProt: P35372 G8XRH5
Position
6q25.2
AA seq 400 aa AA seqDB search
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
NT seq 1203 nt NT seq  +upstreamnt  +downstreamnt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa

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