KEGG   Homo sapiens (human): 4988Help
Entry
4988              CDS       T01001                                 

Gene name
OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Definition
(RefSeq) opioid receptor mu 1
  KO
K04215  mu-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04915  Estrogen signaling pathway
hsa05032  Morphine addiction
Disease
H01611  Alcohol dependence
Drug target
Acetyldihydrocodeine: D07557
Alfentanil (DG00792): D00835 D07122
Alvimopan: D02878
Anileridine (DG00794): D02941 D02942
Asalhydromorphone (DG02967): D11291 D11292
Axelopran (DG01857): D10690 D10740
Benzhydrocodone (DG01850): D10612 D10692
Bevenopran: D10349
Brifentanil hydrochloride: D03156
Buprenorphine (DG00820): D00836 D07132
Butorphanol (DG00821): D00837 D03197
Carfentanil (DG01339): D03405 D07620
Cebranopadol: D10436
Codeine (DG01076): D00195 D02101 D03579 D03580 D07740
Cyclazocine: D03618
Dextropropoxyphene (DG00818): D00482 D05632 D07809
Dezocine: D00838
Diamorphine (DG01003): D07286 D07810
Difenoxin (DG03054): D03809 D11583
Dihydrocodeine (DG00814): D01481 D03825 D07831 D07832
Diphenoxylate (DG00090): D03860 D07861
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403
Eptazocine (DG01340): D01879 D07904
Ethoheptazine citrate: D01435
Ethylmorphine (DG01074): D02205 D07929
Etorphine: D07937
Fentanyl (DG00791): D00320 D01399 D10811
Hydrocodone (DG01075): D03725 D04461 D08045 D08046
Hydromorphone (DG00811): D00839 D08047
Ketobemidone (DG00815): D08100 D08101
Levacetylmethadol (DG01000): D00840 D04716
Levallorphan tartrate: D02238
Levomethadone (DG01002): D08121 D08122
Levorphanol (DG01341): D00841 D08123
Lofentanil oxalate: D04764
Loperamide (DG00092): D00729 D08144
Loperamide oxide (DG00092): D07113
Meptazinol (DG00825): D04924 D08182
Methadone (DG00999): D02102 D08195
Methadyl acetate: D04973
Methylnaltrexone bromide: D06618
Methylsamidorphan (DG01830): D10371 D10648
Mirfentanil hydrochloride: D05048
Morphine (DG00810): D00842 D02271 D08233 D08234
Nalbuphine (DG00822): D00843 D08246
Naldemedine (DG01342): D10188 D10478
Nalmefene (DG00998): D02104 D05111 D10812
Nalorphine (DG01151): D08247 D08248
Naloxegol (DG00078): D10375 D10479
Naloxone (DG01155): D01340 D08249 D11620
Naltrexone (DG00997): D02095 D05113
Nicomorphine (DG00812): D07285 D08273
Ocfentanil hydrochloride: D05217
Oliceridine: D11214
Oxycodegol (DG03013): D11424 D11425
Oxycodone (DG00813): D00847 D03783 D05312 D05462
Oxymorphone (DG01343): D00844 D08323
Pentazocine (DG00819): D00498 D02111 D02227
Pethidine (DG00816): D01383 D08343
Pholcodine: D07385
Propiram fumarate: D05631
Quadazocine mesylate: D05667
Remifentanil (DG00795): D01177 D08473
Samidorphan (DG01538): D10162 D10163
Sufentanil (DG00793): D00845 D05938
Tapentadol (DG00826): D06007 D10199
Tilidine (DG00823): D06147 D08597
Tonazocine mesylate: D06189
Tramadol (DG00824): D01355 D08623
Trefentanil hydrochloride: D06208
Trimebutine (DG00031): D01500 D08639
Trimeperidine: D06268
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4988 (OPRM1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    4988 (OPRM1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    4988 (OPRM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4988 (OPRM1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4988 (OPRM1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Motif
Other DBs
NCBI-GeneID: 4988
NCBI-ProteinID: NP_000905
OMIM: 600018
HGNC: 8156
Ensembl: ENSG00000112038
Vega: OTTHUMG00000015870
Pharos: P35372(Tclin)
UniProt: P35372 G8XRH5
Position
6q25.2
AA seq 400 aa AA seqDB search
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
NT seq 1203 nt NT seq  +upstreamnt  +downstreamnt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (139)   
   KEGG DRUG (139)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (31)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (118)   
   RefSeq(nuc) (32)   
   GenBank (43)   
   EMBL (43)   
Protein domain (4)   
   Pfam (4)   
All databases (314)   

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