KEGG T01001: 4988

Homo sapiens (human): 4988

Entry

4988              CDS       T01001

Symbol

OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM

Name

(RefSeq) opioid receptor mu 1

K04215

mu-type opioid receptor

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04081

Hormone signaling

hsa04082

Neuroactive ligand signaling

hsa04915

Estrogen signaling pathway

hsa05032

Morphine addiction

Drug target

Acetorphine:

D12700

Acetyldihydrocodeine:

D07557

Alfentanil (DG00792):

Allylprodine:

Alphacetylmethadol:

Alphameprodine:

Alphamethadol:

Alphaprodine:

Alvimopan:

D02878<US>

Anileridine (DG00794):

D02941 D02942

Asalhydromorphone (DG02967):

D11291 D11292

Axelopran (DG01857):

D10690 D10740

Benzethidine:

D12685

Benzhydrocodone (DG01850):

Betacetylmethadol:

Betameprodine:

Betamethadol:

Betaprodine:

Bevenopran:

Brifentanil hydrochloride:

D03156

Buprenorphine (DG00820):

D00836<JP/US> D07132<JP/US>

Butorphanol (DG00821):

D00837<US> D03197

Carfentanil (DG01339):

D03405 D07620

Cebranopadol:

D10436

Clonitazene:

D12668

Codeine (DG01076):

D00195 D02101<JP> D03579 D03580<US> D07740

Cyclazocine:

D03618

Dextropropoxyphene (DG00818):

D00482<US> D05632 D07809

Dezocine:

D00838

Diamorphine (DG01003):

D07286 D07810

Diampromide:

D12694

Difenoxin (DG03054):

D03809 D11583

Dihydrocodeine (DG00814):

D01481<JP> D03825 D07831 D07832

Diphenoxylate (DG00090):

D03860 D07861

Diprenorphine (DG01273):

D07863 D07864

Eluxadoline:

D10403<US>

Ethoheptazine citrate:

D01435

Ethylmorphine (DG01074):

Etonitazene:

Etorphine:

Etoxeridine:

Fentanyl (DG00791):

D00320<JP/US> D01399<JP/US> D10811

Furethidine:

D12682

Hydrocodone (DG01075):

D03725<US> D04461 D08045 D08046

Hydromorphinol:

D12686

Hydromorphone (DG00811):

D00839<JP/US> D08047

Hydroxypethidine:

D12681

Isomethadone:

D12676

Ketobemidone (DG00815):

D08100 D08101

Levacetylmethadol (DG01000):

D00840 D04716

Levallorphan tartrate:

D02238<JP>

Levomethadone (DG01002):

D08121 D08122

Levomethorphan:

D12696

Levophenacylmorphan:

D12687

Levorphanol (DG01341):

D00841<US> D08123

Lofentanil oxalate:

D04764

Loperamide (DG00092):

D00729<JP/US> D08144

Loperamide oxide (DG00092):

D07113

Meptazinol (DG00825):

D04924 D08182

Methadone (DG00999):

D02102<JP/US> D08195

Methadyl acetate:

D04973

Methyldesorphine:

D12691

Methyldihydromorphine:

D12689

Methylnaltrexone bromide:

D06618<US>

Methylsamidorphan (DG01830):

D10371 D10648

Metopon:

D12690

Mirfentanil hydrochloride:

D05048

Morpheridin:

D12697

Morphine (DG00810):

D00842<JP/US> D02271<JP> D08233 D08234

Nalbuphine (DG00822):

D00843<US> D08246

Naldemedine (DG01342):

D10188 D10478<JP/US>

Nalmefene (DG00998):

D02104<US> D05111 D10812<JP>

Nalorphine (DG01151):

D08247 D08248

Naloxegol (DG00078):

D10375<US> D10479

Naloxone (DG01155):

D01340<JP/US> D08249 D11620<US>

Naltrexone (DG00997):

D02095<US> D05113<US>

Nicomorphine (DG00812):

D07285 D08273

Norlevorphanol:

D12692

Ocfentanil hydrochloride:

D05217

Oliceridine:

D11214<US>

Oxycodegol (DG03013):

D11424 D11425

Oxycodone (DG00813):

D00847<US> D03783 D05312<US> D05462<JP>

Oxymorphone (DG01343):

D00844<US> D08323

Pentazocine (DG00819):

D00498<JP> D02111 D02227<JP>

Pethidine (DG00816):

D01383<JP/US> D08343

Phenampromide:

Phenomorphan:

Pholcodine:

Piminodine:

Properidine:

Propiram fumarate:

Quadazocine mesylate:

D05667

Remifentanil (DG00795):

D01177<JP/US> D08473

Samidorphan (DG01538):

D10162 D10163

Sufentanil (DG00793):

D00845<US> D05938

Tapentadol (DG00826):

D06007 D10199<US>

Tilidine (DG00823):

D06147 D08597

Tonazocine mesylate:

D06189

Tramadol (DG00824):

D01355<JP/US> D08623

Trefentanil hydrochloride:

D06208

Trimebutine (DG00031):

D01500<JP> D08639

Trimeperidine:

D06268

Xorphanol mesylate:

D06342

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4988 (OPRM1)
   04082 Neuroactive ligand signaling
    4988 (OPRM1)
   04081 Hormone signaling
    4988 (OPRM1)
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    4988 (OPRM1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    4988 (OPRM1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4988 (OPRM1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Peptide
   Opioid
    4988 (OPRM1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

6:154010496..154246867

AA seq 400 aa
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

NT seq 1203 nt +upstreamnt +downstreamnt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa

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