KEGG T01001: 4988

KEGG

Homo sapiens (human): 4988

Entry

4988 CDS T01001

Gene name

OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM

Definition

(RefSeq) opioid receptor mu 1

KO

mu-type opioid receptor

Organism

hsa Homo sapiens (human)

Pathway

Neuroactive ligand-receptor interaction

Estrogen signaling pathway

Morphine addiction

Disease

Alcohol dependence

Drug target

Acetyldihydrocodeine:

Alfentanil (DG00792):

D00835<US> D07122

Alvimopan:

Anileridine (DG00794):

Asalhydromorphone (DG02967):

Axelopran (DG01857):

Benzhydrocodone (DG01850):

Bevenopran:

Brifentanil hydrochloride:

Buprenorphine (DG00820):

D00836<JP/US> D07132<JP/US>

Butorphanol (DG00821):

D00837<US> D03197

Carfentanil (DG01339):

Cebranopadol:

Codeine (DG01076):

D00195 D02101<JP> D03579 D03580<US> D07740

Cyclazocine:

Dextropropoxyphene (DG00818):

D00482<US> D05632 D07809

Dezocine:

Diamorphine (DG01003):

Difenoxin (DG03054):

Dihydrocodeine (DG00814):

D01481<JP> D03825 D07831 D07832

Diphenoxylate (DG00090):

Diprenorphine (DG01273):

Eluxadoline:

Eptazocine (DG01340):

D01879<JP> D07904

Ethoheptazine citrate:

Ethylmorphine (DG01074):

Etorphine:

Fentanyl (DG00791):

D00320<JP/US> D01399<JP/US> D10811

Hydrocodone (DG01075):

D03725<US> D04461 D08045 D08046

Hydromorphone (DG00811):

D00839<JP/US> D08047

Ketobemidone (DG00815):

Levacetylmethadol (DG01000):

Levallorphan tartrate:

Levomethadone (DG01002):

Levorphanol (DG01341):

D00841<US> D08123

Lofentanil oxalate:

Loperamide (DG00092):

D00729<JP/US> D08144

Loperamide oxide (DG00092):

Meptazinol (DG00825):

Methadone (DG00999):

D02102<JP/US> D08195

Methadyl acetate:

Methylnaltrexone bromide:

Methylsamidorphan (DG01830):

Mirfentanil hydrochloride:

Morphine (DG00810):

D00842<JP/US> D02271<JP> D08233 D08234

Nalbuphine (DG00822):

D00843<US> D08246

Naldemedine (DG01342):

D10188 D10478<JP/US>

Nalmefene (DG00998):

D02104 D05111 D10812<JP>

Nalorphine (DG01151):

Naloxegol (DG00078):

D10375<US> D10479

Naloxone (DG01155):

D01340<JP/US> D08249 D11620<US>

Naltrexone (DG00997):

D02095<US> D05113<US>

Nicomorphine (DG00812):

Ocfentanil hydrochloride:

Oliceridine:

Oxycodegol (DG03013):

Oxycodone (DG00813):

D00847<US> D03783 D05312 D05462<JP>

Oxymorphone (DG01343):

D00844<US> D08323

Pentazocine (DG00819):

D00498<JP> D02111 D02227<JP>

Pethidine (DG00816):

D01383<JP/US> D08343

Pholcodine:

Propiram fumarate:

Quadazocine mesylate:

Remifentanil (DG00795):

D01177<JP/US> D08473

Samidorphan (DG01538):

Sufentanil (DG00793):

D00845<US> D05938

Tapentadol (DG00826):

D06007 D10199<JP/US>

Tilidine (DG00823):

Tonazocine mesylate:

Tramadol (DG00824):

D01355<JP/US> D08623

Trefentanil hydrochloride:

Trimebutine (DG00031):

D01500<JP> D08639

Trimeperidine:

Xorphanol mesylate:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4988 (OPRM1)
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    4988 (OPRM1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    4988 (OPRM1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4988 (OPRM1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Peptide
   Opioid
    4988 (OPRM1)

Motif

Pfam:

7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

ENSG00000112038

Vega:

OTTHUMG00000015870

Pharos:

P35372(Tclin)

UniProt:

Position

6q25.2

AA seq 400 aa
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

NT seq 1203 nt +upstreamnt +downstreamnt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa

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