KEGG   Homo sapiens (human): 5024
Entry
5024              CDS       T01001                                 
Symbol
P2RX3, P2X3
Name
(RefSeq) purinergic receptor P2X 3
  KO
K05217  P2X purinoceptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04742  Taste transduction
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01909  Transport of calcium, P2RX
Drug target
Camlipixant: D12785
Eliapixant: D12323
Gefapixant (DG03083): D11349 D11693<JP>
Sivopixant: D12355
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5024 (P2RX3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5024 (P2RX3)
   04082 Neuroactive ligand signaling
    5024 (P2RX3)
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    5024 (P2RX3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5024 (P2RX3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5024 (P2RX3)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 5024
NCBI-ProteinID: NP_002550
OMIM: 600843
HGNC: 8534
Ensembl: ENSG00000109991
UniProt: P56373
Structure
Position
11:57335950..57372396
AA seq 397 aa
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
NT seq 1194 nt   +upstreamnt  +downstreamnt
atgaactgcatatccgacttcttcacctatgagaccaccaagtcggtggttgtgaagagc
tggaccatcgggatcatcaaccgagtagttcagcttctgatcatctcctactttgtaggg
tgggttttcttgcacgagaaggcttaccaggtacgggacacagccattgagtcctcggtg
gtaaccaaggtgaagggctccggactctacgccaacagagtcatggatgtgtctgattac
gtgacgccacctcagggcacctcggtctttgtcatcatcaccaagatgattgttactgaa
aatcagatgcaaggattctgcccagagagtgaggagaaataccgctgtgtatcagacagc
cagtgcgggcctgagcgcttgccaggtggggggatcctcactggccgctgcgtgaactac
agctctgtgctccggacctgtgagatccagggctggtgccccacggaggtggacacagtg
gaaacgcccatcatgatggaagctgagaacttcactattttcatcaagaacagcatccgt
ttccccctcttcaactttgagaagggaaacctccttcccaacctgacagccagggacatg
aagacctgccgcttccacccggacaaggaccctttctgccccatcttgcgggtaggggac
gtggtcaagtttgcggggcaggattttgccaaactggcgcgcacggggggagttctgggc
attaagatcggctgggtgtgcgacttggacaaggcctgggaccagtgcatccccaaatac
tccttcacccggctcgacagcgtttctgagaaaagcagcgtgtccccaggctacaacttc
aggtttgccaagtactacaaaatggaaaatggcagtgagtaccgcaccctcctgaaggct
tttggcatccgcttcgacgtgctggtatacgggaatgctggcaagttcaacatcatcccc
accatcatcagctctgtggcggcctttacttctgtgggagtgggaactgttctctgtgac
atcatcctgctcaacttcctcaagggggccgaccagtacaaagccaagaagtttgaggag
gtgaatgagactacgctgaaaatcgcggctttgaccaacccagtgtaccccagcgaccag
accacagcggagaagcagtccaccgattcgggggccttctccataggccactag

  All links  
Disease (1)   
   OMIM (1)   
Gene (7)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (29)   
   RefSeq(nuc) (13)   
   GenBank (8)   
   EMBL (8)   
3D Structure (13)   
   PDB (13)   
Protein domain (1)   
   Pfam (1)   
All databases (65)   

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