KEGG   Homo sapiens (human): 5045
Entry
5045              CDS       T01001                                 
Symbol
FURIN, FUR, PACE, PCSK3, SPC1
Name
(RefSeq) furin, paired basic amino acid cleaving enzyme
  KO
K01349  furin [EC:3.4.21.75]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa04382  Cornified envelope formation
Network
nt06544  Neuroactive ligand signaling
nt06545  Cornified envelope formation
  Element
N01916  Preprohormone cleavage, POMC
N01917  Preprohormone cleavage, PDYN
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    5045 (FURIN)
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    5045 (FURIN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5045 (FURIN)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5045 (FURIN)
   04131 Membrane trafficking [BR:hsa04131]
    5045 (FURIN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.75  furin
     5045 (FURIN)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5045 (FURIN)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5045 (FURIN)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Others
   Others
    5045 (FURIN)
SSDB
Motif
Pfam: Peptidase_S8 S8_pro-domain P_proprotein Furin-like_2 VSP DUF357
Other DBs
NCBI-GeneID: 5045
NCBI-ProteinID: NP_001276752
OMIM: 136950
HGNC: 8568
Ensembl: ENSG00000140564
UniProt: P09958
Structure
Position
15:90868588..90883457
AA seq 794 aa
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
NT seq 2385 nt   +upstreamnt  +downstreamnt
atggagctgaggccctggttgctatgggtggtagcagcaacaggaaccttggtcctgcta
gcagctgatgctcagggccagaaggtcttcaccaacacgtgggctgtgcgcatccctgga
ggcccagcggtggccaacagtgtggcacggaagcatgggttcctcaacctgggccagatc
ttcggggactattaccacttctggcatcgaggagtgacgaagcggtccctgtcgcctcac
cgcccgcggcacagccggctgcagagggagcctcaagtacagtggctggaacagcaggtg
gcaaagcgacggactaaacgggacgtgtaccaggagcccacagaccccaagtttcctcag
cagtggtacctgtctggtgtcactcagcgggacctgaatgtgaaggcggcctgggcgcag
ggctacacagggcacggcattgtggtctccattctggacgatggcatcgagaagaaccac
ccggacttggcaggcaattatgatcctggggccagttttgatgtcaatgaccaggaccct
gacccccagcctcggtacacacagatgaatgacaacaggcacggcacacggtgtgcgggg
gaagtggctgcggtggccaacaacggtgtctgtggtgtaggtgtggcctacaacgcccgc
attggaggggtgcgcatgctggatggcgaggtgacagatgcagtggaggcacgctcgctg
ggcctgaaccccaaccacatccacatctacagtgccagctggggccccgaggatgacggc
aagacagtggatgggccagcccgcctcgccgaggaggccttcttccgtggggttagccag
ggccgaggggggctgggctccatctttgtctgggcctcggggaacgggggccgggaacat
gacagctgcaactgcgacggctacaccaacagtatctacacgctgtccatcagcagcgcc
acgcagtttggcaacgtgccgtggtacagcgaggcctgctcgtccacactggccacgacc
tacagcagtggcaaccagaatgagaagcagatcgtgacgactgacttgcggcagaagtgc
acggagtctcacacgggcacctcagcctctgcccccttagcagccggcatcattgctctc
accctggaggccaataagaacctcacatggcgggacatgcaacacctggtggtacagacc
tcgaagccagcccacctcaatgccaacgactgggccaccaatggtgtgggccggaaagtg
agccactcatatggctacgggcttttggacgcaggcgccatggtggccctggcccagaat
tggaccacagtggccccccagcggaagtgcatcatcgacatcctcaccgagcccaaagac
atcgggaaacggctcgaggtgcggaagaccgtgaccgcgtgcctgggcgagcccaaccac
atcactcggctggagcacgctcaggcgcggctcaccctgtcctataatcgccgtggcgac
ctggccatccacctggtcagccccatgggcacccgctccaccctgctggcagccaggcca
catgactactccgcagatgggtttaatgactgggccttcatgacaactcattcctgggat
gaggatccctctggcgagtgggtcctagagattgaaaacaccagcgaagccaacaactat
gggacgctgaccaagttcaccctcgtactctatggcaccgcccctgaggggctgcccgta
cctccagaaagcagtggctgcaagaccctcacgtccagtcaggcctgtgtggtgtgcgag
gaaggcttctccctgcaccagaagagctgtgtccagcactgccctccagggttcgccccc
caagtcctcgatacgcactatagcaccgagaatgacgtggagaccatccgggccagcgtc
tgcgccccctgccacgcctcatgtgccacatgccaggggccggccctgacagactgcctc
agctgccccagccacgcctccttggaccctgtggagcagacttgctcccggcaaagccag
agcagccgagagtccccgccacagcagcagccacctcggctgcccccggaggtggaggcg
gggcaacggctgcgggcagggctgctgccctcacacctgcctgaggtggtggccggcctc
agctgcgccttcatcgtgctggtcttcgtcactgtcttcctggtcctgcagctgcgctct
ggctttagttttcggggggtgaaggtgtacaccatggaccgtggcctcatctcctacaag
gggctgccccctgaagcctggcaggaggagtgcccgtctgactcagaagaggacgagggc
cggggcgagaggaccgcctttatcaaagaccagagcgccctctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (10)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (28)   
   RefSeq(nuc) (8)   
   GenBank (10)   
   EMBL (10)   
3D Structure (40)   
   PDB (40)   
Protein domain (6)   
   Pfam (6)   
All databases (94)   

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