KEGG   Homo sapiens (human): 5046
Entry
5046              CDS       T01001                                 
Symbol
PCSK6, PACE4, SPC4
Name
(RefSeq) proprotein convertase subtilisin/kexin type 6
  KO
K08672  proprotein convertase subtilisin/kexin type 6 [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
Network
nt06545  Cornified envelope formation
  Element
N01930  Processing of profilaggrin to filaggrin and binding to keratin filaments
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    5046 (PCSK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5046 (PCSK6)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5046 (PCSK6)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5046 (PCSK6)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5046 (PCSK6)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain GF_recep_IV Furin-like_2 PLAC VSP
Other DBs
NCBI-GeneID: 5046
NCBI-ProteinID: NP_002561
OMIM: 167405
HGNC: 8569
Ensembl: ENSG00000140479
UniProt: P29122 A2RQD9
Position
15:complement(101303933..101489707)
AA seq 969 aa
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
CCRTCLLAG
NT seq 2910 nt   +upstreamnt  +downstreamnt
atgcctccgcgcgcgccgcctgcgcccgggccccggccgccgccccgggccgccgccgcc
accgacaccgccgcgggcgcggggggcgcggggggcgcggggggcgccggcgggcccggg
ttccggccgctcgcgccgcgtccctggcgctggctgctgctgctggcgctgcctgccgcc
tgctccgcgcccccgccgcgccccgtctacaccaaccactgggcggtgcaagtgctgggc
ggcccggccgaggcggaccgcgtggcggcggcgcacgggtacctcaacttgggccagatt
ggaaacctggaagattactaccatttttatcacagcaaaacctttaaaagatcaaccttg
agtagcagaggccctcacaccttcctcagaatggacccccaggtgaaatggctccagcaa
caggaagtgaaacgaagggtgaagagacaggtgcgaagtgacccgcaggccctttacttc
aacgaccccatttggtccaacatgtggtacctgcattgtggcgacaagaacagtcgctgc
cggtcggaaatgaatgtccaggcagcgtggaagaggggctacacaggaaaaaacgtggtg
gtcaccatccttgatgatggcatagagagaaatcaccctgacctggccccaaattatgat
tcctacgccagctacgacgtgaacggcaatgattatgacccatctccacgatatgatgcc
agcaatgaaaataaacacggcactcgttgtgcgggagaagttgctgcttcagcaaacaat
tcctactgcatcgtgggcatagcgtacaatgccaaaataggaggcatccgcatgctggac
ggcgatgtcacagatgtggtcgaggcaaagtcgctgggcatcagacccaactacatcgac
atttacagtgccagctgggggccggacgacgacggcaagacggtggacgggcccggccga
ctggctaagcaggctttcgagtatggcattaaaaagggccggcagggcctgggctccatt
ttcgtctgggcatctgggaatggcgggagagagggggactactgctcgtgcgatggctac
accaacagcatctacaccatctccgtcagcagcgccaccgagaatggctacaagccctgg
tacctggaagagtgtgcctccaccctggccaccacctacagcagtggggccttttatgag
cgaaaaatcgtcaccacggatctgcgtcagcgctgtaccgatggccacactgggacctca
gtctctgcccccatggtggcgggcatcatcgccttggctctagaagcaaacagccagtta
acctggagggacgtccagcacctgctagtgaagacatcccggccggcccacctgaaagcg
agcgactggaaagtgaacggcgcgggtcataaagttagccatttctatggatttggtttg
gtggacgcagaagctctcgttgtggaggcaaagaagtggacagcagtgccatcgcagcac
atgtgtgtggccgcctcggacaagagacccaggagcatccccttagtgcaggtgctgcgg
actacggccctgaccagcgcctgcgcggagcactcggaccagcgggtggtctacttggag
cacgtggtggttcgcacctccatctcacacccacgccgaggagacctccagatctacctg
gtttctccctcgggaaccaagtctcaacttctggcaaagaggttgctggatctttccaat
gaagggtttacaaactgggaattcatgactgtccactgctggggagaaaaggctgaaggg
cagtggaccttggaaatccaagatctgccatcccaggtccgcaacccggagaagcaaggg
aagttgaaagaatggagcctcatactgtatggcacagcagagcacccgtaccacaccttc
agtgcccatcagtcccgctcgcggatgctggagctctcagccccagagctggagccaccc
aaggctgccctgtcaccctcccaggtggaagttcctgaagatgaggaagattacacagct
caatccaccccaggctctgctaatattttacagaccagtgtgtgccatccggagtgtggt
gacaaaggctgtgatggccccaatgcagaccagtgcttgaactgcgtccacttcagcctg
gggagtgtcaagaccagcaggaagtgcgtgagtgtgtgccccttgggctactttggggac
acagcagcaagacgctgtcgccggtgccacaaggggtgtgagacctgctccagcagagct
gcgacgcagtgcctgtcttgccgccgcgggttctatcaccaccaggagatgaacacctgt
gtgaccctctgtcctgcaggattttatgctgatgaaagtcagaaaaattgccttaaatgc
cacccaagctgtaaaaagtgcgtggatgaacctgagaaatgtactgtctgtaaagaagga
ttcagccttgcacggggcagctgcattcctgactgtgagccaggcacctactttgactca
gagctgatcagatgtggggaatgccatcacacctgcggaacctgcgtggggccaggcaga
gaagagtgcattcactgtgcgaaaaacttccacttccacgactggaagtgtgtgccagcc
tgtggtgagggcttctacccagaagagatgccgggcttgccccacaaagtgtgtcgaagg
tgtgacgagaactgcttgagctgtgcaggctccagcaggaactgtagcaggtgtaagacg
ggcttcacacagctggggacctcctgcatcaccaaccacacgtgcagcaacgctgacgag
acattctgcgagatggtgaagtccaaccggctgtgcgaacggaagctcttcattcagttc
tgctgccgcacgtgcctcctggccgggtaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (41)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (45)   
   RefSeq(nuc) (9)   
   GenBank (18)   
   EMBL (18)   
Protein domain (7)   
   Pfam (7)   
All databases (104)   

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