KEGG   Homo sapiens (human): 50507
Entry
50507             CDS       T01001                                 

Symbol
NOX4, KOX, KOX-1, RENOX
Name
(RefSeq) NADPH oxidase 4
  KO
K21423  NADPH oxidase 4 [EC:1.6.3.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    50507 (NOX4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    50507 (NOX4)
   05022 Pathways of neurodegeneration - multiple diseases
    50507 (NOX4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    50507 (NOX4)
   04933 AGE-RAGE signaling pathway in diabetic complications
    50507 (NOX4)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.3  With oxygen as acceptor
    1.6.3.-  
     50507 (NOX4)
SSDB
Motif
Pfam: Ferric_reduct NAD_binding_6 FAD_binding_8 NAD_binding_1 Autoind_bind
Other DBs
NCBI-GeneID: 50507
NCBI-ProteinID: NP_058627
OMIM: 605261
HGNC: 7891
Ensembl: ENSG00000086991
Vega: OTTHUMG00000167298
Pharos: Q9NPH5(Tchem)
UniProt: Q9NPH5
Position
11:complement(89324353..89589557)
AA seq 578 aa
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
NT seq 1737 nt   +upstreamnt  +downstreamnt
atggctgtgtcctggaggagctggctcgccaacgaaggggttaaacacctctgcctgttc
atctggctctccatgaatgtcctgcttttctggaaaaccttcttgctgtataaccaaggg
ccagagtatcactacctccaccagatgttggggctaggattgtgtctaagcagagcctca
gcatctgttcttaacctcaactgcagccttatccttttacccatgtgccgaacactcttg
gcttacctccgaggatcacagaaggttccaagcaggagaaccaggagattgttggataaa
agcagaacattccatattacctgtggtgttactatctgtattttctcaggcgtgcatgtg
gctgcccatctggtgaatgccctcaacttctcagtgaattacagtgaagactttgttgaa
ctgaatgcagcaagataccgagatgaggatcctagaaaacttctcttcacaactgttcct
ggcctgacaggggtctgcatggtggtggtgctattcctcatgatcacagcctctacatat
gcaataagagtttctaactatgatatcttctggtatactcataacctcttctttgtcttc
tacatgctgctgacgttgcatgtttcaggagggctgctgaagtatcaaactaatttagat
acccaccctcccggctgcatcagtcttaaccgaaccagctctcagaatatttccttacca
gagtatttctcagaacattttcatgaacctttccctgaaggattttcaaaaccggcagag
tttacccagcacaaatttgtgaagatttgtatggaagagcccagattccaagctaatttt
ccacagacttggctttggatttctggacctttgtgcctgtactgtgccgaaagactttac
aggtatatccggagcaataagccagtcaccatcatttcggtcatgagtcatccctcagat
gtcatggaaatccgaatggtcaaagaaaattttaaagcaagacctggtcagtatattact
ctacattgtcccagtgtatctgcattagaaaatcatccatttaccctcacaatgtgtcca
actgaaaccaaagcaacatttggggttcatcttaaaatagtaggagactggacagaacga
tttcgagatttactactgcctccatctagtcaagactccgaaattctgcccttcattcaa
tctagaaattatcccaagctgtatattgatggtccttttggaagtccatttgaggaatca
ctgaactatgaggtcagcctctgcgtggctggaggcattggagtaactccatttgcatca
atactcaacaccctgttggatgactggaaaccatacaagcttagaagactatactttatt
tgggtatgcagagatatccagtccttccgttggtttgcagatttactctgtatgttgcat
aacaagttttggcaagagaacagacctgactatgtcaacatccagctgtacctcagtcaa
acagatgggatacagaagataattggagaaaaatatcatgcactgaattcaagactgttt
ataggacgtcctcggtggaaacttttgtttgatgaaatagcaaaatataacagaggaaaa
acagttggtgttttctgttgtggacccaattcactatccaagactcttcataaactgagt
aaccagaacaactcatatgggacaagatttgaatacaataaagagtctttcagctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (61)   
   RefSeq(nuc) (15)   
   GenBank (23)   
   EMBL (23)   
Protein domain (5)   
   Pfam (5)   
All databases (123)   

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