KEGG   Homo sapiens (human): 5054Help
Entry
5054              CDS       T01001                                 

Gene name
SERPINE1, PAI, PAI-1, PAI1, PLANH1
Definition
(RefSeq) serpin family E member 1
  KO
K03982  plasminogen activator inhibitor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04371  Apelin signaling pathway
hsa04390  Hippo signaling pathway
hsa04610  Complement and coagulation cascades
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05142  Chagas disease (American trypanosomiasis)
Disease
H00223  Inherited thrombophilia
H01106  Plasminogen activator inhibitor type 1 (PAI-1) deficiency
H01529  Avascular necrosis of femoral head
H01709  Glucocorticoid-induced osteonecrosis
Drug target
Aleplasinin: D08656
Diaplasinin: D03766
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    5054 (SERPINE1)
   04371 Apelin signaling pathway
    5054 (SERPINE1)
   04066 HIF-1 signaling pathway
    5054 (SERPINE1)
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    5054 (SERPINE1)
   04218 Cellular senescence
    5054 (SERPINE1)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5054 (SERPINE1)
 09160 Human Diseases
  09166 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    5054 (SERPINE1)
  09167 Infectious diseases
   05142 Chagas disease (American trypanosomiasis)
    5054 (SERPINE1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5054 (SERPINE1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    5054 (SERPINE1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   5054 (SERPINE1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate/Haparin
  Coagulation and fibrinolysis
   5054 (SERPINE1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Serpin DUF5038
Motif
Other DBs
NCBI-GeneID: 5054
NCBI-ProteinID: NP_000593
OMIM: 173360
HGNC: 8583
Ensembl: ENSG00000106366
Vega: OTTHUMG00000157107
Pharos: P05121(Tchem)
UniProt: P05121 A0A024QYT5
Structure
PDB: 

Position
7q22.1
AA seq 402 aa AA seqDB search
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
NT seq 1209 nt NT seq  +upstreamnt  +downstreamnt
atgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaa
gggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtg
agggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctat
ggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcag
attcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcat
ctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatc
ttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttc
cggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaat
gactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtg
gaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagact
cccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtc
tctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgat
ggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcatt
gctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccag
ctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaag
ttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgac
atgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtc
gcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctca
tccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagaccc
ttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatg
gaaccctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Disease (6)   
   KEGG DISEASE (4)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (53)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (3)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (33)   
   OC (1)   
   PHAROS (1)   
   PROTHERM (8)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (42)   
   RefSeq(nuc) (2)   
   GenBank (20)   
   EMBL (20)   
Protein domain (2)   
   Pfam (2)   
All databases (121)   

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