KEGG   Homo sapiens (human): 5054
Entry
5054              CDS       T01001                                 
Symbol
SERPINE1, PAI, PAI-1, PAI1, PLANH1
Name
(RefSeq) serpin family E member 1
  KO
K03982  plasminogen activator inhibitor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04371  Apelin signaling pathway
hsa04390  Hippo signaling pathway
hsa04610  Complement and coagulation cascades
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05142  Chagas disease
Network
nt06514  Coagulation cascade
  Element
N01524  Regulation of fibrinolytic system, PAI
Disease
H01106  Plasminogen activator inhibitor type 1 deficiency
H01529  Avascular necrosis of femoral head
Drug target
Aleplasinin: D08656
Diaplasinin: D03766
Tiplasinin: D06160
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    5054 (SERPINE1)
   04371 Apelin signaling pathway
    5054 (SERPINE1)
   04066 HIF-1 signaling pathway
    5054 (SERPINE1)
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    5054 (SERPINE1)
   04218 Cellular senescence
    5054 (SERPINE1)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5054 (SERPINE1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05142 Chagas disease
    5054 (SERPINE1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    5054 (SERPINE1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5054 (SERPINE1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5054 (SERPINE1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    5054 (SERPINE1)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I4: serpin family
   5054 (SERPINE1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   5054 (SERPINE1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   5054 (SERPINE1)
SSDB
Motif
Pfam: Serpin
Other DBs
NCBI-GeneID: 5054
NCBI-ProteinID: NP_000593
OMIM: 173360
HGNC: 8583
Ensembl: ENSG00000106366
UniProt: P05121
Structure
Position
7:101127104..101139247
AA seq 402 aa
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
NT seq 1209 nt   +upstreamnt  +downstreamnt
atgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaa
gggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtg
agggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctat
ggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcag
attcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcat
ctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatc
ttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttc
cggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaat
gactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtg
gaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagact
cccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtc
tctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgat
ggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcatt
gctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccag
ctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaag
ttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgac
atgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtc
gcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctca
tccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagaccc
ttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatg
gaaccctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (47)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (33)   
   OC (1)   
   PROTHERM (8)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (53)   
   RefSeq(nuc) (13)   
   GenBank (20)   
   EMBL (20)   
3D Structure (29)   
   PDB (29)   
Protein domain (1)   
   Pfam (1)   
All databases (146)   

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