KEGG   Homo sapiens (human): 5066Help
Entry
5066              CDS       T01001                                 

Gene name
PAM, PAL, PHM
Definition
(RefSeq) peptidylglycine alpha-amidating monooxygenase
  KO
K24006  peptidylglycine monooxygenase / peptidylamidoglycolate lyase [EC:1.14.17.3 4.3.2.5]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99980 Enzymes with EC numbers
    5066 (PAM)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.17  With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.17.3  peptidylglycine monooxygenase
     5066 (PAM)
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.2  Amidine-lyases
    4.3.2.5  peptidylamidoglycolate lyase
     5066 (PAM)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Cu2_monoox_C NHL Cu2_monooxygen SGL Motilin_ghrelin
Motif
Other DBs
NCBI-GeneID: 5066
NCBI-ProteinID: NP_001170777
OMIM: 170270
HGNC: 8596
Ensembl: ENSG00000145730
Vega: OTTHUMG00000128729
Pharos: P19021(Tchem)
UniProt: P19021
Position
5q21.1
AA seq 973 aa AA seqDB search
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS
NT seq 2922 nt NT seq  +upstreamnt  +downstreamnt
atggctggccgcgtccctagcctgctagttctccttgtttttccaagcagctgtttggct
ttccgaagcccactttctgtctttaagaggtttaaagaaactaccagaccattttccaat
gaatgtcttggtaccaccagacccgtagttcctattgattcatcagattttgcattggat
attcgcatgcctggggttacacctaaacagtccgatacatacttctgcatgtctatgcga
ataccagtggatgaggaagccttcgtgattgacttcaagcctcgagccagcatggatact
gtccatcacatgttactttttggatgcaatatgccttcatccactggaagttactggttt
tgtgatgaaggaacctgtacagataaagccaatattctgtatgcctgggcgagaaatgct
ccccctacccggctccccaaaggtgttggattcagagttggaggagagactggaagtaaa
tactttgtactacaggtacactatggggatattagtgcttttagagataataacaaggac
tgttctggtgtgtccttacacctcacacgtctgccacagcctttaattgctggcatgtac
cttatgatgtctgttgacactgttatcccagcaggagaaaaagtggtgaattctgacatt
tcatgccattataaaaattatccaatgcatgtctttgcctatagagttcacactcaccat
ttaggtaaggtagtaagtggatacagagtaagaaatggacagtggacactgattggacgg
cagagccctcagctgccacaggctttctaccctgtggggcatccagttgatgtaagtttt
ggtgacctactggctgcaagatgtgtattcactggtgaaggaaggacagaagccacacac
attggtggcacgtctagtgatgaaatgtgcaacttatacattatgtattacatggaagcc
aagcatgcagtttctttcatgacctgtacccagaatgtagctccagatatgttcagaacc
ataccaccagaggccaacattccaattcccgtgaagtctgatatggttatgatgcatgaa
catcataaagaaacagaatataaagataagattcctttactacagcagccaaaacgagaa
gaagaagaagtgttagaccagggtgatttctattcactactttccaagctgctaggagaa
agggaagatgttgttcatgtgcacaaatataatcctacagaaaaggcagaatcagagtca
gacctggtagctgagattgcaaatgtagtccaaaaaaaggatcttggtcgatctgatgcc
agagagggtgcagaacatgagaggggtaatgctattcttgtcagagacagaattcacaaa
ttccacagactagtatctaccttgaggccaccagagagcagagttttctcattacagcag
cccccacctggtgaaggcacctgggaaccagaacacacaggagatttccacatggaagag
gcactggattggcctggagtatacttgttaccaggccaggtttctggggtggctctagac
cctaagaataacctggtgattttccacagaggtgaccatgtctgggatggaaactcgttt
gacagcaagtttgtttaccagcaaataggactcggaccaattgaagaagacactattctt
gtcatagatccaaataatgctgcagtactccagtccagtggaaaaaatctgttttacttg
ccacatggcttgagtatagataaagatgggaattattgggtcacagacgtggctctccat
caggtgttcaaactggatccaaacaataaagaaggccctgtattaatcctgggaaggagc
atgcaaccaggcagtgaccagaatcacttctgtcaacccactgatgtggctgtggatcca
ggcactggagccatttatgtatcagatggttactgcaacagcaggattgtgcagttttca
ccaagtggaaagttcatcacacagtggggagaagagtcttcagggagcagtcctctgcca
ggccagttcactgttcctcacagcttggctcttgtgcctcttttgggccaattatgtgtg
gcagaccgggaaaatggtcggatccagtgttttaaaactgacaccaaagaatttgtgaga
gagattaagcattcatcatttggaagaaatgtatttgcaatttcatatataccaggcttg
ctctttgcagtgaatgggaagcctcattttggggaccaagaacctgtacaaggatttgtg
atgaacttttccaatggggaaattatagacatcttcaagccagtgcgcaagcactttgat
atgcctcatgatattgttgcatctgaagatgggactgtgtacattggagatgctcatacc
aacaccgtgtggaagttcaccttgactgagaaattggaacatcgatcagttaaaaaggct
ggcattgaggtccaggaaatcaaagaagccgaggcagttgttgaaaccaaaatggagaac
aaacccacctcctcagaattgcagaagatgcaagagaaacagaaactgatcaaagagcca
ggctcgggagtgcctgttgttctcattacaacccttctggttattccggtggttgtcctg
ctggccattgccatatttattcggtggaaaaaatcaagggcctttggagattctgaacac
aaactcgagacgagttcaggaagagtactgggaagatttagaggaaagggaagtggaggc
ttaaaccttggtaatttctttgcaagccgtaagggctacagtcgaaaagggtttgaccgg
cttagcactgagggcagtgaccaagagaaagaggatgatggaagtgaatcagaagaggag
tattcagcacctctgcctgcgctcgcaccttcctcctcctga

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