KEGG   Homo sapiens (human): 51107Help
Entry
51107             CDS       T01001                                 

Gene name
APH1A, 6530402N02Rik, APH-1, APH-1A, CGI-78
Definition
(RefSeq) aph-1 homolog A, gamma-secretase subunit
  KO
K06172  gamma-secretase subunit APH-1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04330  Notch signaling pathway
hsa05010  Alzheimer disease
Module
hsa_M00682  Notch signaling
Drug target
Avagacestat: D09869
Begacestat: D08869
Semagacestat: D09377
Tarenflurbil: D09010
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    51107 (APH1A)
 09160 Human Diseases
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    51107 (APH1A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Aph-1 Peptidase_M3_N
Motif
Other DBs
NCBI-GeneID: 51107
NCBI-ProteinID: NP_001071096
OMIM: 607629
HGNC: 29509
Ensembl: ENSG00000117362
Vega: OTTHUMG00000012545
Pharos: Q96BI3(Tbio)
UniProt: Q96BI3
Structure
PDB: 

Position
1q21.2
AA seq 265 aa AA seqDB search
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
RSLLCRRQEDSRVMVYSALRIPPED
NT seq 798 nt NT seq  +upstreamnt  +downstreamnt
atgggggctgcggtgtttttcggctgcactttcgtcgcgttcggcccggccttcgcgctt
ttcttgatcactgtggctggggacccgcttcgcgttatcatcctggtcgcaggggcattt
ttctggctggtctccctgctcctggcctctgtggtctggttcatcttggtccatgtgacc
gaccggtcagatgcccggctccagtacggcctcctgatttttggtgctgctgtctctgtc
cttctacaggaggtgttccgctttgcctactacaagctgcttaagaaggcagatgagggg
ttagcatcgctgagtgaggacggaagatcacccatctccatccgccagatggcctatgtt
tctggtctctccttcggtatcatcagtggtgtcttctctgttatcaatattttggctgat
gcacttgggccaggtgtggttgggatccatggagactcaccctattacttcctgacttca
gcctttctgacagcagccattatcctgctccataccttttggggagttgtgttctttgat
gcctgtgagaggagacggtactgggctttgggcctggtggttgggagtcacctactgaca
tcgggactgacattcctgaacccctggtatgaggccagcctgctgcccatctatgcagtc
actgtttccatggggctctgggccttcatcacagctggagggtccctccgaagtattcag
cgcagcctcttgtgccgacggcaggaggacagtcgggtgatggtgtattctgccctgcgc
atcccacccgaggactga

DBGET integrated database retrieval system