KEGG   Homo sapiens (human): 51311
Entry
51311             CDS       T01001                                 
Symbol
TLR8, CD288, IMD98, TLR-8, hTLR8
Name
(RefSeq) toll like receptor 8
  KO
K10170  toll-like receptor 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa05171  Coronavirus disease - COVID-19
Network
nt06517  TLR signaling
  Element
N01543  TLR7/8/9-IRF5 signaling pathway
Disease
H00096  Defects of toll-like receptor signaling
Drug target
Enpatoran: D12261
Motolimod: D10716
Resiquimod sulfate: D13051
Selgantolimod: D11871
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    51311 (TLR8)
   04620 Toll-like receptor signaling pathway
    51311 (TLR8)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    51311 (TLR8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    51311 (TLR8)
   04090 CD molecules [BR:hsa04090]
    51311 (TLR8)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   51311 (TLR8)
CD molecules [BR:hsa04090]
 Proteins
  51311 (TLR8)
SSDB
Motif
Pfam: LRR_8 LRR_4 TIR LRR_14 LRR_5 TIR_2 LRR_NXF1-5 LRR_12 LRR_LRWD1 LRR_9
Other DBs
NCBI-GeneID: 51311
NCBI-ProteinID: NP_619542
OMIM: 300366
HGNC: 15632
Ensembl: ENSG00000101916
UniProt: Q9NR97
Structure
Position
X:12906620..12923169
AA seq 1041 aa
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
NT seq 3126 nt   +upstreamnt  +downstreamnt
atggaaaacatgttccttcagtcgtcaatgctgacctgcattttcctgctaatatctggt
tcctgtgagttatgcgccgaagaaaatttttctagaagctatccttgtgatgagaaaaag
caaaatgactcagttattgcagagtgcagcaatcgtcgactacaggaagttccccaaacg
gtgggcaaatatgtgacagaactagacctgtctgataatttcatcacacacataacgaat
gaatcatttcaagggctgcaaaatctcactaaaataaatctaaaccacaaccccaatgta
cagcaccagaacggaaatcccggtatacaatcaaatggcttgaatatcacagacggggca
ttcctcaacctaaaaaacctaagggagttactgcttgaagacaaccagttaccccaaata
ccctctggtttgccagagtctttgacagaacttagtctaattcaaaacaatatatacaac
ataactaaagagggcatttcaagacttataaacttgaaaaatctctatttggcctggaac
tgctattttaacaaagtttgcgagaaaactaacatagaagatggagtatttgaaacgctg
acaaatttggagttgctatcactatctttcaattctctttcacacgtgccacccaaactg
ccaagctccctacgcaaactttttctgagcaacacccagatcaaatacattagtgaagaa
gatttcaagggattgataaatttaacattactagatttaagcgggaactgtccgaggtgc
ttcaatgccccatttccatgcgtgccttgtgatggtggtgcttcaattaatatagatcgt
tttgcttttcaaaacttgacccaacttcgatacctaaacctctctagcacttccctcagg
aagattaatgctgcctggtttaaaaatatgcctcatctgaaggtgctggatcttgaattc
aactatttagtgggagaaatagcctctggggcatttttaacgatgctgccccgcttagaa
atacttgacttgtcttttaactatataaaggggagttatccacagcatattaatatttcc
agaaacttctctaaacttttgtctctacgggcattgcatttaagaggttatgtgttccag
gaactcagagaagatgatttccagcccctgatgcagcttccaaacttatcgactatcaac
ttgggtattaattttattaagcaaatcgatttcaaacttttccaaaatttctccaatctg
gaaattatttacttgtcagaaaacagaatatcaccgttggtaaaagatacccggcagagt
tatgcaaatagttcctcttttcaacgtcatatccggaaacgacgctcaacagattttgag
tttgacccacattcgaacttttatcatttcacccgtcctttaataaagccacaatgtgct
gcttatggaaaagccttagatttaagcctcaacagtattttcttcattgggccaaaccaa
tttgaaaatcttcctgacattgcctgtttaaatctgtctgcaaatagcaatgctcaagtg
ttaagtggaactgaattttcagccattcctcatgtcaaatatttggatttgacaaacaat
agactagactttgataatgctagtgctcttactgaattgtccgacttggaagttctagat
ctcagctataattcacactatttcagaatagcaggcgtaacacatcatctagaatttatt
caaaatttcacaaatctaaaagttttaaacttgagccacaacaacatttatactttaaca
gataagtataacctggaaagcaagtccctggtagaattagttttcagtggcaatcgcctt
gacattttgtggaatgatgatgacaacaggtatatctccattttcaaaggtctcaagaat
ctgacacgtctggatttatcccttaataggctgaagcacatcccaaatgaagcattcctt
aatttgccagcgagtctcactgaactacatataaatgataatatgttaaagttttttaac
tggacattactccagcagtttcctcgtctcgagttgcttgacttacgtggaaacaaacta
ctctttttaactgatagcctatctgactttacatcttcccttcggacactgctgctgagt
cataacaggatttcccacctaccctctggctttctttctgaagtcagtagtctgaagcac
ctcgatttaagttccaatctgctaaaaacaatcaacaaatccgcacttgaaactaagacc
accaccaaattatctatgttggaactacacggaaacccctttgaatgcacctgtgacatt
ggagatttccgaagatggatggatgaacatctgaatgtcaaaattcccagactggtagat
gtcatttgtgccagtcctggggatcaaagagggaagagtattgtgagtctggagctaaca
acttgtgtttcagatgtcactgcagtgatattatttttcttcacgttctttatcaccacc
atggttatgttggctgccctggctcaccatttgttttactgggatgtttggtttatatat
aatgtgtgtttagctaaggtaaaaggctacaggtctctttccacatcccaaactttctat
gatgcttacatttcttatgacaccaaagatgcctctgttactgactgggtgataaatgag
ctgcgctaccaccttgaagagagccgagacaaaaacgttctcctttgtctagaggagagg
gattgggacccgggattggccatcatcgacaacctcatgcagagcatcaaccaaagcaag
aaaacagtatttgttttaaccaaaaaatatgcaaaaagctggaactttaaaacagctttt
tacttggctttgcagaggctaatggatgagaacatggatgtgattatatttatcctgctg
gagccagtgttacagcattctcagtatttgaggctacggcagcggatctgtaagagctcc
atcctccagtggcctgacaacccgaaggcagaaggcttgttttggcaaactctgagaaat
gtggtcttgactgaaaatgattcacggtataacaatatgtatgtcgattccattaagcaa
tactaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (30)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (30)   
   RefSeq(nuc) (2)   
   GenBank (14)   
   EMBL (14)   
3D Structure (39)   
   PDB (39)   
Protein domain (10)   
   Pfam (10)   
All databases (115)   

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