KEGG   Homo sapiens (human): 5133
Entry
5133              CDS       T01001                                 
Symbol
PDCD1, AIMTBS, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Name
(RefSeq) programmed cell death 1
  KO
K06744  programmed cell death protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
Disease
H01232  Syndromic multisystem autoimmune disease
H01490  Multiple sclerosis
H01812  Rasmussen encephalitis
H02540  Infantile-onset multisystem autoimmune disease
Drug target
Balstilimab: D11820
Budigalimab: D11643
Cadonilimab: D12190
Cemiplimab: D11108<JP/US>
Cetrelimab: D11488
Dostarlimab: D11366<US>
Eciskafusp alfa: D12791
Ivonescimab: D12808
Izuralimab: D12195
Nivolumab: D10316<JP/US>
Pacmilimab: D11948
Pembrolizumab: D10574<JP/US>
Penpulimab: D12198<US>
Peresolimab: D12231
Pidilizumab: D10390
Retifanlimab: D11827<US>
Rilvegostomig: D12764
Rosnilimab: D12223
Sasanlimab: D12839
Serplulimab: D12751
Sintilimab: D12119
Spartalizumab: D11605
Tislelizumab: D11487<JP/US>
Tobemstomig: D12961
Toripalimab: D12202<US>
Volrustomig: D12347
Vudalimab: D12186
Zeluvalimab: D12332
Zimberelimab: D12063
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    5133 (PDCD1)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5133 (PDCD1)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5133 (PDCD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    5133 (PDCD1)
CD molecules [BR:hsa04090]
 Proteins
  5133 (PDCD1)
SSDB
Motif
Pfam: V-set ig Ig_3 Ig_2 I-set DUF2550
Other DBs
NCBI-GeneID: 5133
NCBI-ProteinID: NP_005009
OMIM: 600244
HGNC: 8760
Ensembl: ENSG00000188389
UniProt: Q15116 A0A0M3M0G7
Structure
Position
2:complement(241849884..241858894)
AA seq 288 aa
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTS
ESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGT
YLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGS
LVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVP
CVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
NT seq 867 nt   +upstreamnt  +downstreamnt
atgcagatcccacaggcgccctggccagtcgtctgggcggtgctacaactgggctggcgg
ccaggatggttcttagactccccagacaggccctggaacccccccaccttctccccagcc
ctgctcgtggtgaccgaaggggacaacgccaccttcacctgcagcttctccaacacatcg
gagagcttcgtgctaaactggtaccgcatgagccccagcaaccagacggacaagctggcc
gccttccccgaggaccgcagccagcccggccaggactgccgcttccgtgtcacacaactg
cccaacgggcgtgacttccacatgagcgtggtcagggcccggcgcaatgacagcggcacc
tacctctgtggggccatctccctggcccccaaggcgcagatcaaagagagcctgcgggca
gagctcagggtgacagagagaagggcagaagtgcccacagcccaccccagcccctcaccc
aggccagccggccagttccaaaccctggtggttggtgtcgtgggcggcctgctgggcagc
ctggtgctgctagtctgggtcctggccgtcatctgctcccgggccgcacgagggacaata
ggagccaggcgcaccggccagcccctgaaggaggacccctcagccgtgcctgtgttctct
gtggactatggggagctggatttccagtggcgagagaagaccccggagccccccgtgccc
tgtgtccctgagcagacggagtatgccaccattgtctttcctagcggaatgggcacctca
tcccccgcccgcaggggctcagctgacggccctcggagtgcccagccactgaggcctgag
gatggacactgctcttggcccctctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (13)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (40)   
   RefSeq(nuc) (4)   
   GenBank (18)   
   EMBL (18)   
3D Structure (35)   
   PDB (35)   
Protein domain (6)   
   Pfam (6)   
All databases (103)   

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