KEGG   Homo sapiens (human): 5145
Entry
5145              CDS       T01001                                 

Gene name
PDE6A, CGPR-A, PDEA, RP43
Definition
(RefSeq) phosphodiesterase 6A
  KO
K08718  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04744  Phototransduction
Disease
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    5145 (PDE6A)
 09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    5145 (PDE6A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     5145 (PDE6A)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3 SpoVT_C
Other DBs
NCBI-GeneID: 5145
NCBI-ProteinID: NP_000431
OMIM: 180071
HGNC: 8785
Ensembl: ENSG00000132915
Vega: OTTHUMG00000130047
Pharos: P16499(Tclin)
UniProt: P16499
Position
5q32
AA seq 860 aa
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ
NT seq 2583 nt   +upstreamnt  +downstreamnt
atgggcgaggtgacagcagaggaggtggagaagttcctggactcgaatattggctttgcc
aaacagtactacaacctccactaccgggccaagctcatctccgacctccttggggccaag
gaggctgccgtggacttcagcaactaccactccccgagcagcatggaggagagcgaaatc
atctttgatctcctgcgggactttcaggagaatttacagacagagaaatgcatcttcaat
gtcatgaagaagctgtgcttcctcctgcaggcagaccgcatgagcctgttcatgtaccgg
acccgcaatggcatcgcagagctggccaccaggcttttcaatgtccacaaggatgctgtc
ctcgaggactgcctggtgatgcccgaccaagagatcgtcttccctttggacatgggcatc
gtgggccatgtcgcacactctaagaagattgctaacgtccccaacacagaggaggatgag
catttctgtgactttgtggacatcctcacagagtacaagaccaagaacatcttggcttcc
cccataatgaatgggaaggatgtggtggccataatcatggctgtgaataaagtggatgga
tcccacttcaccaagagagatgaagagattcttctcaagtacctcaattttgcaaatcta
atcatgaaggtgtaccacctgagttacctgcacaactgtgaaactcgacgtggccagata
ctgctgtggtctgggagcaaagtctttgaagaacttacggacatcgaacgacagttccac
aaagccctgtacacagtccgtgctttcctcaactgtgacagatactctgtgggtctctta
gacatgaccaagcagaaggaattttttgatgtgtggccggttctgatgggtgaagttcca
ccttactctggtcccaggactccggatggaagagaaattaacttttacaaggtcattgac
tacatcctgcatggcaaagaggacatcaaagtcatcccgaatccacctcctgaccattgg
gctttagtaagcggtctcccagcttatgttgcccagaatggcctgatttgcaacatcatg
aatgcgcctgcggaggacttttttgcatttcagaaagaacctctggatgagtctggatgg
atgattaaaaatgtgctttcaatgccgattgtgaacaagaaggaagaaattgttggagtg
gccacattttacaatcgtaaagatgggaagccctttgatgaaatggatgagacgctcatg
gagtctttgactcaatttctgggctggtctgtcttaaatcctgacacctatgagtcaatg
aataaacttgaaaataggaaggatattttccaggacatagtaaaatatcatgtgaagtgt
gacaatgaagaaattcagaaaatcttgaaaaccagagaggtgtatgggaaggagccatgg
gagtgtgaggaagaggagctggctgagatcctgcaagcggagctgccagatgcagataaa
tacgaaattaataaatttcacttcagtgacttacccctaacagaactggagctggtaaaa
tgtggaatacagatgtattatgagctcaaagtggtggataaatttcacattccacaagag
gccctggtgcggttcatgtactccctgagtaagggctaccgcaagatcacctaccacaac
tggcggcacggcttcaacgtggggcagaccatgttctccctgctggtgacgggaaagctg
aagcgctacttcacggacctagaggccttggccatggtcactgctgctttctgccatgac
attgaccacagaggcaccaataacctctaccagatgaaatcccagaacccactggccaag
ctccatgggtcctctatcttggaaagacaccacttggagtttggcaaaacactgctcaga
gacgagagcctgaatatctttcaaaacctcaatcgtcgacagcatgagcatgccatccac
atgatggacattgcaatcattgccacagacctcgccctgtatttcaagaagaggacgatg
ttccaaaagatcgtggatcagtctaagacatatgagagtgaacaggagtggacacagtac
atgatgctggagcagacacggaaggaaatcgttatggccatgatgatgaccgcctgtgat
ctctcagccatcaccaaaccctgggaggtgcagagccaggtagctctgctggtggctgct
gaattctgggaacaaggtgacctggagcgcacggtgctgcaacagaatcccattcccatg
atggacagaaacaaagcagatgaactccctaagcttcaagtcggcttcattgactttgtt
tgcaccttcgtctacaaggaattctcccgtttccacgaggagatcaccccaatgttggac
gggatcaccaacaatcgcaaggagtggaaggcgcttgctgatgagtacgatgccaagatg
aaggtgcaggaggagaagaagcagaaacagcagtcggccaagtcagcagccgcaggaaat
cagccggggggaaaccccagcccagggggtgcaactacatccaagtcctgctgcatccag
taa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (21)   
   RefSeq(nuc) (7)   
   GenBank (7)   
   EMBL (7)   
Protein domain (5)   
   Pfam (5)   
All databases (62)   

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