KEGG   Homo sapiens (human): 5152
Entry
5152              CDS       T01001                                 
Symbol
PDE9A, HSPDE9A2
Name
(RefSeq) phosphodiesterase 9A
  KO
K13761  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
Drug target
Edelinontrine: D13001
Tovinontrine: D12203
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    5152 (PDE9A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     5152 (PDE9A)
SSDB
Motif
Pfam: PDEase_I HD-CE GcvP2_C
Other DBs
NCBI-GeneID: 5152
NCBI-ProteinID: NP_002597
OMIM: 602973
HGNC: 8795
Ensembl: ENSG00000160191
UniProt: O76083 A0A0S2Z4T6
Structure
Position
21:42653621..42775509
AA seq 593 aa
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgggatccggctcctccagctaccggcccaaggccatctacctggacatcgatggacgc
attcagaaggtaatcttcagcaagtactgcaactccagcgacatcatggacctgttctgc
atcgccaccggcctgcctcggaacacgaccatctccctgctgaccaccgacgacgccatg
gtctccatcgaccccaccatgcccgcgaattcagaacgcactccgtacaaagtgagacct
gtggccatcaagcaactctccgctggtgtcgaggacaagagaaccacaagccgtggccag
tctgctgagagaccactgagggacagacgggttgtgggcctggagcagccccggagggaa
ggagcatttgaaagtggacaggtagagcccaggcccagagagccccagggctgctaccag
gaaggccagcgcatccctccagagagagaagaattaatccagagcgtgctggcgcaggtt
gcagagcagttctcaagagcattcaaaatcaatgaactgaaagctgaagttgcaaatcac
ttggctgtcctagagaaacgcgtggaattggaaggactaaaagtggtggagattgagaaa
tgcaagagtgacattaagaagatgagggaggagctggcggccagaagcagcaggaccaac
tgcccctgtaagtacagttttttggataaccacaagaagttgactcctcgacgcgatgtt
cccacttaccccaagtacctgctctctccagagaccatcgaggccctgcggaagccgacc
tttgacgtctggctttgggagcccaatgagatgctgagctgcctggagcacatgtaccac
gacctcgggctggtcagggacttcagcatcaaccctgtcaccctcaggaggtggctgttc
tgcgtccacgacaactacagaaacaaccccttccacaacttccggcactgcttctgcgtg
gcccagatgatgtacagcatggtctggctctgcagtctccaggagaagttctcacaaacg
gatatcctgatcctaatgacagcggccatctgccacgatctggaccatcccggctacaac
aacacgtaccagatcaatgcccgcacagagctggcggtccgctacaatgacatctcaccg
ctggagaaccaccactgcgccgtggccttccagatcctcgccgagcctgagtgcaacatc
ttctccaacatcccacctgatgggttcaagcagatccgacagggaatgatcacattaatc
ttggccactgacatggcaagacatgcagaaattatggattctttcaaagagaaaatggag
aattttgactacagcaacgaggagcacatgaccctgctgaagatgattttgataaaatgc
tgtgatatctctaacgaggtccgtccaatggaagtcgcagagccttgggtggactgttta
ttagaggaatattttatgcagagcgaccgtgagaagtcagaaggccttcctgtggcaccg
ttcatggaccgagacaaagtgaccaaggccacagcccagattgggttcatcaagtttgtc
ctgatcccaatgtttgaaacagtgaccaagctcttccccatggttgaggagatcatgctg
cagccactttgggaatcccgagatcgctacgaggagctgaagcggatagatgacgccatg
aaagagttacagaagaagactgacagcttgacgtctggggccaccgagaagtccagagag
agaagcagagatgtgaaaaacagtgaaggagactgtgcctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (16)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (31)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (100)   
   RefSeq(nuc) (28)   
   GenBank (36)   
   EMBL (36)   
3D Structure (25)   
   PDB (25)   
Protein domain (3)   
   Pfam (3)   
All databases (176)   

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