KEGG   Homo sapiens (human): 5168
Entry
5168              CDS       T01001                                 

Gene name
ENPP2, ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
Definition
(RefSeq) ectonucleotide pyrophosphatase/phosphodiesterase 2
  KO
K01122  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [EC:3.1.4.39]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00565  Ether lipid metabolism
Drug target
Ziritaxestat: D11844
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00565 Ether lipid metabolism
    5168 (ENPP2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.39  alkylglycerophosphoethanolamine phosphodiesterase
     5168 (ENPP2)
SSDB
Motif
Pfam: Phosphodiest Somatomedin_B Endonuclease_NS Sulfatase
Other DBs
NCBI-GeneID: 5168
NCBI-ProteinID: NP_001035181
OMIM: 601060
HGNC: 3357
Ensembl: ENSG00000136960
Vega: OTTHUMG00000164995
Pharos: Q13822(Tchem)
UniProt: Q13822
Structure
PDB: 

Position
8q24.12
AA seq 863 aa
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
NT seq 2592 nt   +upstreamnt  +downstreamnt
atggcaaggaggagctcgttccagtcgtgtcagataatatccctgttcacttttgccgtt
ggagtcaatatctgcttaggattcactgcacatcgaattaagagagcagaaggatgggag
gaaggtcctcctacagtgctatcagactccccctggaccaacatctccggatcttgcaag
ggcaggtgctttgaacttcaagaggctggacctcctgattgtcgctgtgacaacttgtgt
aagagctataccagttgctgccatgactttgatgagctgtgtttgaagacagcccgtggc
tgggagtgtactaaggacagatgtggagaagtcagaaatgaagaaaatgcctgtcactgc
tcagaggactgcttggccaggggagactgctgtaccaattaccaagtggtttgcaaagga
gagtcgcattgggttgatgatgactgtgaggaaataaaggccgcagaatgccctgcaggg
tttgttcgccctccattaatcatcttctccgtggatggcttccgtgcatcatacatgaag
aaaggcagcaaagtcatgcctaatattgaaaaactaaggtcttgtggcacacactctccc
tacatgaggccggtgtacccaactaaaacctttcctaacttatacactttggccactggg
ctatatccagaatcacatggaattgttggcaattcaatgtatgatcctgtatttgatgcc
acttttcatctgcgagggcgagagaaatttaatcatagatggtggggaggtcaaccgcta
tggattacagccaccaagcaaggggtgaaagctggaacattcttttggtctgttgtcatc
cctcacgagcggagaatattaaccatattgcagtggctcaccctgccagatcatgagagg
ccttcggtctatgccttctattctgagcaacctgatttctctggacacaaatatggccct
ttcggccctgagatgacaaatcctctgagggaaatcgacaaaattgtggggcaattaatg
gatggactgaaacaactaaaactgcatcggtgtgtcaacgtcatctttgtcggagaccat
ggaatggaagatgtcacatgtgatagaactgagttcttgagtaattacctaactaatgtg
gatgatattactttagtgcctggaactctaggaagaattcgatccaaatttagcaacaat
gctaaatatgaccccaaagccattattgccaatctcacgtgtaaaaaaccagatcagcac
tttaagccttacttgaaacagcaccttcccaaacgtttgcactatgccaacaacagaaga
attgaggatatccatttattggtggaacgcagatggcatgttgcaaggaaacctttggat
gtttataagaaaccatcaggaaaatgctttttccagggagaccacggatttgataacaag
gtcaacagcatgcagactgtttttgtaggttatggctcaacatttaagtacaagactaaa
gtgcctccatttgaaaacattgaactttacaatgttatgtgtgatctcctgggattgaag
ccagctcctaataatgggacccatggaagtttgaatcatctcctgcgcactaataccttc
aggccaaccatgccagaggaagttaccagacccaattatccagggattatgtaccttcag
tctgattttgacctgggctgcacttgtgatgataaggtagagccaaagaacaagttggat
gaactcaacaaacggcttcatacaaaagggtctacagaagagagacacctcctctatggg
cgacctgcagtgctttatcggactagatatgatatcttatatcacactgactttgaaagt
ggttatagtgaaatattcctaatgccactctggacatcatatactgtttccaaacaggct
gaggtttccagcgttcctgaccatctgaccagttgcgtccggcctgatgtccgtgtttct
ccgagtttcagtcagaactgtttggcctacaaaaatgataagcagatgtcctacggattc
ctctttcctccttatctgagctcttcaccagaggctaaatatgatgcattccttgtaacc
aatatggttccaatgtatcctgctttcaaacgggtctggaattatttccaaagggtattg
gtgaagaaatatgcttcggaaagaaatggagttaacgtgataagtggaccaatcttcgac
tatgactatgatggcttacatgacacagaagacaaaataaaacagtacgtggaaggcagt
tccattcctgttccaactcactactacagcatcatcaccagctgtctggatttcactcag
cctgccgacaagtgtgacggccctctctctgtgtcctccttcatcctgcctcaccggcct
gacaacgaggagagctgcaatagctcagaggacgaatcaaaatgggtagaagaactcatg
aagatgcacacagctagggtgcgtgacattgaacatctcaccagcctggacttcttccga
aagaccagccgcagctacccagaaatcctgacactcaagacatacctgcatacatatgag
agcgagatttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (54)   
   RefSeq(nuc) (14)   
   GenBank (20)   
   EMBL (20)   
Protein domain (4)   
   Pfam (4)   
All databases (102)   

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