KEGG   Homo sapiens (human): 5265
Entry
5265              CDS       T01001                                 

Symbol
SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF
Name
(RefSeq) serpin family A member 1
  KO
K03984  alpha-1-antitrypsin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Disease
H01103  Alpha-1-antitrypsin deficiency
H01714  Chronic obstructive pulmonary disease (COPD)
Drug target
alfa1 Antitrypsin: D11965<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5265 (SERPINA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5265 (SERPINA1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5265 (SERPINA1)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I4: serpin family
   5265 (SERPINA1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   5265 (SERPINA1)
SSDB
Motif
Pfam: Serpin
Other DBs
NCBI-GeneID: 5265
NCBI-ProteinID: NP_000286
OMIM: 107400
HGNC: 8941
Ensembl: ENSG00000197249
Vega: OTTHUMG00000150355
Pharos: P01009(Tbio)
UniProt: P01009 E9KL23
Structure
PDB: 

Position
14q32.13
AA seq 418 aa
MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFS
LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF
QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQ
INDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTV
KVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFL
ENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKA
VLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
NT seq 1257 nt   +upstreamnt  +downstreamnt
atgccgtcttctgtctcgtggggcatcctcctgctggcaggcctgtgctgcctggtccct
gtctccctggctgaggatccccagggagatgctgcccagaagacagatacatcccaccat
gatcaggatcacccaaccttcaacaagatcacccccaacctggctgagttcgccttcagc
ctataccgccagctggcacaccagtccaacagcaccaatatcttcttctccccagtgagc
atcgctacagcctttgcaatgctctccctggggaccaaggctgacactcacgatgaaatc
ctggagggcctgaatttcaacctcacggagattccggaggctcagatccatgaaggcttc
caggaactcctccgtaccctcaaccagccagacagccagctccagctgaccaccggcaat
ggcctgttcctcagcgagggcctgaagctagtggataagtttttggaggatgttaaaaag
ttgtaccactcagaagccttcactgtcaacttcggggacaccgaagaggccaagaaacag
atcaacgattacgtggagaagggtactcaagggaaaattgtggatttggtcaaggagctt
gacagagacacagtttttgctctggtgaattacatcttctttaaaggcaaatgggagaga
ccctttgaagtcaaggacaccgaggaagaggacttccacgtggaccaggtgaccaccgtg
aaggtgcctatgatgaagcgtttaggcatgtttaacatccagcactgtaagaagctgtcc
agctgggtgctgctgatgaaatacctgggcaatgccaccgccatcttcttcctgcctgat
gaggggaaactacagcacctggaaaatgaactcacccacgatatcatcaccaagttcctg
gaaaatgaagacagaaggtctgccagcttacatttacccaaactgtccattactggaacc
tatgatctgaagagcgtcctgggtcaactgggcatcactaaggtcttcagcaatggggct
gacctctccggggtcacagaggaggcacccctgaagctctccaaggccgtgcataaggct
gtgctgaccatcgacgagaaagggactgaagctgctggggccatgtttttagaggccata
cccatgtctatcccccccgaggtcaagttcaacaaaccctttgtcttcttaatgattgaa
caaaataccaagtctcccctcttcatgggaaaagtggtgaatcccacccaaaaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (114)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
   PHAROS (1)   
   PROTHERM (94)   
   VEGA (1)   
Protein sequence (15)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (106)   
   RefSeq(nuc) (12)   
   GenBank (47)   
   EMBL (47)   
Protein domain (1)   
   Pfam (1)   
All databases (246)   

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