KEGG   Homo sapiens (human): 5290Help
Entry
5290              CDS       T01001                                 

Gene name
PIK3CA, CLAPO, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05100  Bacterial invasion of epithelial cells
hsa05135  Yersinia infection
hsa05142  Chagas disease (American trypanosomiasis)
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06114  PI3K signaling (virus)
nt06124  Chemokine signaling (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00159  KSHV K1 to PI3K signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00267  HBV HBx to PI3K signaling pathway
N00272  HCV NS5A to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00368  HPV E5 to PDGFR-PI3K signaling pathway
N00385  HCMV gB to PDGFR-PI3K signaling pathway
N00387  HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00431  HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
N00485  EBV LMP1 to PI3K signaling pathway
N00501  HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00684  MV F/H to CD28-PI3K signaling pathway
N00736  IAV NS1 to PI3K signaling pathway
Disease
H00027  Ovarian cancer
H00031  Breast cancer
H00048  Hepatocellular carcinoma
H01102  Pituitary adenomas
H01222  Cowden syndrome
H01431  Cushing syndrome
H01912  Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
H01985  Desmoplastic small round cell tumor
H02153  Megalencephaly-capillary malformation syndrome
H02297  CLAPO syndrome
Drug target
Alpelisib: D11011
Apitolisib: D10543
Bimiralisib: D11440
Buparlisib (DG01823): D10584 D10609
Copanlisib (DG01926): D10797 D10798 D10867
Dactolisib (DG01826): D10552 D10616
Gedatolisib: D10635
Leniolisib (DG02927): D11158 D11159
Omipalisib: D10718
Pictilisib: D10189
Samotolisib: D11501
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5290 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5290 (PIK3CA)
   04015 Rap1 signaling pathway
    5290 (PIK3CA)
   04012 ErbB signaling pathway
    5290 (PIK3CA)
   04370 VEGF signaling pathway
    5290 (PIK3CA)
   04630 Jak-STAT signaling pathway
    5290 (PIK3CA)
   04668 TNF signaling pathway
    5290 (PIK3CA)
   04066 HIF-1 signaling pathway
    5290 (PIK3CA)
   04068 FoxO signaling pathway
    5290 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    5290 (PIK3CA)
   04072 Phospholipase D signaling pathway
    5290 (PIK3CA)
   04071 Sphingolipid signaling pathway
    5290 (PIK3CA)
   04024 cAMP signaling pathway
    5290 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    5290 (PIK3CA)
   04152 AMPK signaling pathway
    5290 (PIK3CA)
   04150 mTOR signaling pathway
    5290 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5290 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    5290 (PIK3CA)
   04218 Cellular senescence
    5290 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5290 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    5290 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5290 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5290 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    5290 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    5290 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    5290 (PIK3CA)
   04660 T cell receptor signaling pathway
    5290 (PIK3CA)
   04662 B cell receptor signaling pathway
    5290 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    5290 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    5290 (PIK3CA)
   04670 Leukocyte transendothelial migration
    5290 (PIK3CA)
   04062 Chemokine signaling pathway
    5290 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5290 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    5290 (PIK3CA)
   04915 Estrogen signaling pathway
    5290 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    5290 (PIK3CA)
   04917 Prolactin signaling pathway
    5290 (PIK3CA)
   04926 Relaxin signaling pathway
    5290 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    5290 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5290 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5290 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    5290 (PIK3CA)
   04722 Neurotrophin signaling pathway
    5290 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5290 (PIK3CA)
  09158 Development
   04360 Axon guidance
    5290 (PIK3CA)
   04380 Osteoclast differentiation
    5290 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    5290 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    5290 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5290 (PIK3CA)
   05206 MicroRNAs in cancer
    5290 (PIK3CA)
   05205 Proteoglycans in cancer
    5290 (PIK3CA)
   05203 Viral carcinogenesis
    5290 (PIK3CA)
   05230 Central carbon metabolism in cancer
    5290 (PIK3CA)
   05231 Choline metabolism in cancer
    5290 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5290 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5290 (PIK3CA)
   05212 Pancreatic cancer
    5290 (PIK3CA)
   05225 Hepatocellular carcinoma
    5290 (PIK3CA)
   05226 Gastric cancer
    5290 (PIK3CA)
   05214 Glioma
    5290 (PIK3CA)
   05221 Acute myeloid leukemia
    5290 (PIK3CA)
   05220 Chronic myeloid leukemia
    5290 (PIK3CA)
   05218 Melanoma
    5290 (PIK3CA)
   05211 Renal cell carcinoma
    5290 (PIK3CA)
   05215 Prostate cancer
    5290 (PIK3CA)
   05213 Endometrial cancer
    5290 (PIK3CA)
   05224 Breast cancer
    5290 (PIK3CA)
   05222 Small cell lung cancer
    5290 (PIK3CA)
   05223 Non-small cell lung cancer
    5290 (PIK3CA)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    5290 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5290 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5290 (PIK3CA)
   04931 Insulin resistance
    5290 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5290 (PIK3CA)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    5290 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    5290 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5290 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    5290 (PIK3CA)
   05162 Measles
    5290 (PIK3CA)
   05164 Influenza A
    5290 (PIK3CA)
   05161 Hepatitis B
    5290 (PIK3CA)
   05160 Hepatitis C
    5290 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    5290 (PIK3CA)
   05163 Human cytomegalovirus infection
    5290 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5290 (PIK3CA)
   05169 Epstein-Barr virus infection
    5290 (PIK3CA)
   05165 Human papillomavirus infection
    5290 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5290 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    5290 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5290 (PIK3CA)
   01524 Platinum drug resistance
    5290 (PIK3CA)
   01522 Endocrine resistance
    5290 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5290 (PIK3CA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5290 (PIK3CA)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5290 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 ASC DUF4135
Motif
Other DBs
NCBI-GeneID: 5290
NCBI-ProteinID: NP_006209
OMIM: 171834
HGNC: 8975
Ensembl: ENSG00000121879
Vega: OTTHUMG00000157311
Pharos: P42336(Tchem)
UniProt: P42336 Q4LE51
Structure
PDB: 

Position
3q26.32
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagtcacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

KEGG   Homo sapiens (human): 5291Help
Entry
5291              CDS       T01001                                 

Gene name
PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05100  Bacterial invasion of epithelial cells
hsa05135  Yersinia infection
hsa05142  Chagas disease (American trypanosomiasis)
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06114  PI3K signaling (virus)
nt06124  Chemokine signaling (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00159  KSHV K1 to PI3K signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00267  HBV HBx to PI3K signaling pathway
N00272  HCV NS5A to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00368  HPV E5 to PDGFR-PI3K signaling pathway
N00385  HCMV gB to PDGFR-PI3K signaling pathway
N00387  HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00431  HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
N00485  EBV LMP1 to PI3K signaling pathway
N00501  HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00684  MV F/H to CD28-PI3K signaling pathway
N00736  IAV NS1 to PI3K signaling pathway
Drug target
Apitolisib: D10543
Bimiralisib: D11440
Buparlisib (DG01823): D10584 D10609
Dactolisib (DG01826): D10552 D10616
Gedatolisib: D10635
Leniolisib (DG02927): D11158 D11159
Omipalisib: D10718
Pictilisib: D10189
Samotolisib: D11501
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5291 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5291 (PIK3CB)
   04015 Rap1 signaling pathway
    5291 (PIK3CB)
   04012 ErbB signaling pathway
    5291 (PIK3CB)
   04370 VEGF signaling pathway
    5291 (PIK3CB)
   04630 Jak-STAT signaling pathway
    5291 (PIK3CB)
   04668 TNF signaling pathway
    5291 (PIK3CB)
   04066 HIF-1 signaling pathway
    5291 (PIK3CB)
   04068 FoxO signaling pathway
    5291 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    5291 (PIK3CB)
   04072 Phospholipase D signaling pathway
    5291 (PIK3CB)
   04071 Sphingolipid signaling pathway
    5291 (PIK3CB)
   04024 cAMP signaling pathway
    5291 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    5291 (PIK3CB)
   04152 AMPK signaling pathway
    5291 (PIK3CB)
   04150 mTOR signaling pathway
    5291 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5291 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    5291 (PIK3CB)
   04218 Cellular senescence
    5291 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5291 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    5291 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5291 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5291 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    5291 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    5291 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    5291 (PIK3CB)
   04660 T cell receptor signaling pathway
    5291 (PIK3CB)
   04662 B cell receptor signaling pathway
    5291 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    5291 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    5291 (PIK3CB)
   04670 Leukocyte transendothelial migration
    5291 (PIK3CB)
   04062 Chemokine signaling pathway
    5291 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5291 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    5291 (PIK3CB)
   04915 Estrogen signaling pathway
    5291 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    5291 (PIK3CB)
   04917 Prolactin signaling pathway
    5291 (PIK3CB)
   04926 Relaxin signaling pathway
    5291 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    5291 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5291 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5291 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    5291 (PIK3CB)
   04722 Neurotrophin signaling pathway
    5291 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5291 (PIK3CB)
  09158 Development
   04360 Axon guidance
    5291 (PIK3CB)
   04380 Osteoclast differentiation
    5291 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    5291 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    5291 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5291 (PIK3CB)
   05205 Proteoglycans in cancer
    5291 (PIK3CB)
   05203 Viral carcinogenesis
    5291 (PIK3CB)
   05230 Central carbon metabolism in cancer
    5291 (PIK3CB)
   05231 Choline metabolism in cancer
    5291 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5291 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5291 (PIK3CB)
   05212 Pancreatic cancer
    5291 (PIK3CB)
   05225 Hepatocellular carcinoma
    5291 (PIK3CB)
   05226 Gastric cancer
    5291 (PIK3CB)
   05214 Glioma
    5291 (PIK3CB)
   05221 Acute myeloid leukemia
    5291 (PIK3CB)
   05220 Chronic myeloid leukemia
    5291 (PIK3CB)
   05218 Melanoma
    5291 (PIK3CB)
   05211 Renal cell carcinoma
    5291 (PIK3CB)
   05215 Prostate cancer
    5291 (PIK3CB)
   05213 Endometrial cancer
    5291 (PIK3CB)
   05224 Breast cancer
    5291 (PIK3CB)
   05222 Small cell lung cancer
    5291 (PIK3CB)
   05223 Non-small cell lung cancer
    5291 (PIK3CB)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    5291 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5291 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5291 (PIK3CB)
   04931 Insulin resistance
    5291 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5291 (PIK3CB)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    5291 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    5291 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5291 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    5291 (PIK3CB)
   05162 Measles
    5291 (PIK3CB)
   05164 Influenza A
    5291 (PIK3CB)
   05161 Hepatitis B
    5291 (PIK3CB)
   05160 Hepatitis C
    5291 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    5291 (PIK3CB)
   05163 Human cytomegalovirus infection
    5291 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5291 (PIK3CB)
   05169 Epstein-Barr virus infection
    5291 (PIK3CB)
   05165 Human papillomavirus infection
    5291 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5291 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    5291 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5291 (PIK3CB)
   01524 Platinum drug resistance
    5291 (PIK3CB)
   01522 Endocrine resistance
    5291 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5291 (PIK3CB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5291 (PIK3CB)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5291 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381 DUF4135
Motif
Other DBs
NCBI-GeneID: 5291
NCBI-ProteinID: NP_006210
OMIM: 602925
HGNC: 8976
Ensembl: ENSG00000051382
Vega: OTTHUMG00000159893
Pharos: P42338(Tchem)
UniProt: P42338
Position
3q22.3
AA seq 1070 aa AA seqDB search
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcatcgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaacagagccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaagaaatgattgccata
gaggctgccataaatcgaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaactctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcatgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

KEGG   Homo sapiens (human): 5293Help
Entry
5293              CDS       T01001                                 

Gene name
PIK3CD, APDS, IMD14, P110DELTA, PI3K, p110D
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05100  Bacterial invasion of epithelial cells
hsa05135  Yersinia infection
hsa05142  Chagas disease (American trypanosomiasis)
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06114  PI3K signaling (virus)
nt06124  Chemokine signaling (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00159  KSHV K1 to PI3K signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00267  HBV HBx to PI3K signaling pathway
N00272  HCV NS5A to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00368  HPV E5 to PDGFR-PI3K signaling pathway
N00385  HCMV gB to PDGFR-PI3K signaling pathway
N00387  HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00431  HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
N00485  EBV LMP1 to PI3K signaling pathway
N00501  HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00684  MV F/H to CD28-PI3K signaling pathway
N00736  IAV NS1 to PI3K signaling pathway
Disease
H01387  Activated PI3K-delta syndrome
Drug target
Apitolisib: D10543
Bimiralisib: D11440
Buparlisib (DG01823): D10584 D10609
Copanlisib (DG01926): D10797 D10798 D10867
Dactolisib (DG01826): D10552 D10616
Dezapelisib: D10924
Duvelisib: D10555
Gedatolisib: D10635
Idelalisib: D10560
Leniolisib (DG02927): D11158 D11159
Nemiralisib (DG02995): D11267 D11354
Omipalisib: D10718
Parsaclisib (DG03025): D11437 D11506
Pictilisib: D10189
Samotolisib: D11501
Umbralisib (DG02988): D11322 D11323
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5293 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5293 (PIK3CD)
   04015 Rap1 signaling pathway
    5293 (PIK3CD)
   04012 ErbB signaling pathway
    5293 (PIK3CD)
   04370 VEGF signaling pathway
    5293 (PIK3CD)
   04630 Jak-STAT signaling pathway
    5293 (PIK3CD)
   04668 TNF signaling pathway
    5293 (PIK3CD)
   04066 HIF-1 signaling pathway
    5293 (PIK3CD)
   04068 FoxO signaling pathway
    5293 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    5293 (PIK3CD)
   04072 Phospholipase D signaling pathway
    5293 (PIK3CD)
   04071 Sphingolipid signaling pathway
    5293 (PIK3CD)
   04024 cAMP signaling pathway
    5293 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    5293 (PIK3CD)
   04152 AMPK signaling pathway
    5293 (PIK3CD)
   04150 mTOR signaling pathway
    5293 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5293 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    5293 (PIK3CD)
   04218 Cellular senescence
    5293 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5293 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    5293 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5293 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5293 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    5293 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    5293 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    5293 (PIK3CD)
   04660 T cell receptor signaling pathway
    5293 (PIK3CD)
   04662 B cell receptor signaling pathway
    5293 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    5293 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    5293 (PIK3CD)
   04670 Leukocyte transendothelial migration
    5293 (PIK3CD)
   04062 Chemokine signaling pathway
    5293 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5293 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    5293 (PIK3CD)
   04915 Estrogen signaling pathway
    5293 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    5293 (PIK3CD)
   04917 Prolactin signaling pathway
    5293 (PIK3CD)
   04926 Relaxin signaling pathway
    5293 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    5293 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5293 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5293 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    5293 (PIK3CD)
   04722 Neurotrophin signaling pathway
    5293 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5293 (PIK3CD)
  09158 Development
   04360 Axon guidance
    5293 (PIK3CD)
   04380 Osteoclast differentiation
    5293 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    5293 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    5293 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5293 (PIK3CD)
   05205 Proteoglycans in cancer
    5293 (PIK3CD)
   05203 Viral carcinogenesis
    5293 (PIK3CD)
   05230 Central carbon metabolism in cancer
    5293 (PIK3CD)
   05231 Choline metabolism in cancer
    5293 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5293 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5293 (PIK3CD)
   05212 Pancreatic cancer
    5293 (PIK3CD)
   05225 Hepatocellular carcinoma
    5293 (PIK3CD)
   05226 Gastric cancer
    5293 (PIK3CD)
   05214 Glioma
    5293 (PIK3CD)
   05221 Acute myeloid leukemia
    5293 (PIK3CD)
   05220 Chronic myeloid leukemia
    5293 (PIK3CD)
   05218 Melanoma
    5293 (PIK3CD)
   05211 Renal cell carcinoma
    5293 (PIK3CD)
   05215 Prostate cancer
    5293 (PIK3CD)
   05213 Endometrial cancer
    5293 (PIK3CD)
   05224 Breast cancer
    5293 (PIK3CD)
   05222 Small cell lung cancer
    5293 (PIK3CD)
   05223 Non-small cell lung cancer
    5293 (PIK3CD)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    5293 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5293 (PIK3CD)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5293 (PIK3CD)
   04931 Insulin resistance
    5293 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5293 (PIK3CD)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    5293 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    5293 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5293 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    5293 (PIK3CD)
   05162 Measles
    5293 (PIK3CD)
   05164 Influenza A
    5293 (PIK3CD)
   05161 Hepatitis B
    5293 (PIK3CD)
   05160 Hepatitis C
    5293 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    5293 (PIK3CD)
   05163 Human cytomegalovirus infection
    5293 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5293 (PIK3CD)
   05169 Epstein-Barr virus infection
    5293 (PIK3CD)
   05165 Human papillomavirus infection
    5293 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5293 (PIK3CD)
   05142 Chagas disease (American trypanosomiasis)
    5293 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5293 (PIK3CD)
   01524 Platinum drug resistance
    5293 (PIK3CD)
   01522 Endocrine resistance
    5293 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5293 (PIK3CD)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5293 (PIK3CD)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5293 (PIK3CD)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4135 DOCK-C2
Motif
Other DBs
NCBI-GeneID: 5293
NCBI-ProteinID: NP_005017
OMIM: 602839
HGNC: 8977
Ensembl: ENSG00000171608
Vega: OTTHUMG00000001450
Pharos: O00329(Tclin)
UniProt: O00329 A0A2K8FKV1
Structure
PDB: 

Position
1p36.22
AA seq 1044 aa AA seqDB search
MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH
MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP
GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP
HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR
QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt NT seq  +upstreamnt  +downstreamnt
atgccccctggggtggactgccccatggaattctggaccaaggaggagaatcagagcgtt
gtggttgacttcctgctgcccacaggggtctacctgaacttccctgtgtcccgcaatgcc
aacctcagcaccatcaagcagctgctgtggcaccgcgcccagtatgagccgctcttccac
atgctcagtggccccgaggcctatgtgttcacctgcatcaaccagacagcggagcagcaa
gagctggaggacgagcaacggcgtctgtgtgacgtgcagcccttcctgcccgtcctgcgc
ctggtggcccgtgagggcgaccgcgtgaagaagctcatcaactcacagatcagcctcctc
atcggcaaaggcctccacgagtttgactccttgtgcgacccagaagtgaacgactttcgc
gccaagatgtgccaattctgcgaggaggcggccgcccgccggcagcagctgggctgggag
gcctggctgcagtacagtttccccctgcagctggagccctcggctcaaacctgggggcct
ggtaccctgcggctcccgaaccgggcccttctggtcaacgttaagtttgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggacgtgccgctggcgctgatggcctgtgcc
ctgcggaagaaggccacagtgttccggcagccgctggtggagcagccggaagactacacg
ctgcaggtgaacggcaggcatgagtacctgtatggcagctacccgctctgccagttccag
tacatctgcagctgcctgcacagtgggttgacccctcacctgaccatggtccattcctcc
tccatcctcgccatgcgggatgagcagagcaaccctgccccccaggtccagaaaccgcgt
gccaaaccacctcccattcctgcgaagaagccttcctctgtgtccctgtggtccctggag
cagccgttccgcatcgagctcatccagggcagcaaagtgaacgccgacgagcggatgaag
ctggtggtgcaggccgggcttttccacggcaacgagatgctgtgcaagacggtgtccagc
tcggaggtgagcgtgtgctcggagcccgtgtggaagcagcggctggagttcgacatcaac
atctgcgacctgccccgcatggcccgtctctgctttgcgctgtacgccgtgatcgagaaa
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg
gccaacctcatgctgtttgactacaaggaccagcttaagaccggggaacgctgcctctac
atgtggccctccgtcccagatgagaagggcgagctgctgaaccccacgggcactgtgcgc
agtaaccccaacacggatagcgccgctgccctgctcatctgcctgcccgaggtggccccg
caccccgtgtactaccccgccctggagaagatcttggagctggggcgacacagcgagtgt
gtgcatgtcaccgaggaggagcagctgcagctgcgggaaatcctggagcggcgggggtct
ggggagctgtatgagcacgagaaggacctggtgtggaagctgcggcatgaagtccaggag
cacttcccggaggcgctagcccggctgctgctggtcaccaagtggaacaagcatgaggat
gtggcccagatgctctacctgctgtgctcctggccggagctgcccgtcctgagcgccctg
gagctgctagacttcagcttccccgattgccacgtaggctccttcgccatcaagtcgctg
cggaaactgacggacgatgagctgttccagtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctggactgcgagctgaccaaattcctgctggaccgggccctggccaac
cgcaagatcggccacttccttttctggcacctccgctccgagatgcacgtgccgtcggtg
gccctgcgcttcggcctcatcctggaggcctactgcaggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagcactgagcaaactgaaggccctgaatgacttcgtcaag
ctgagctctcagaagacccccaagccccagaccaaggagctgatgcacttgtgcatgcgg
caggaggcctacctagaggccctctcccacctgcagtccccactcgaccccagcaccctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
atcatgtacagcaacgaggaggcaggcagcggcggcagcgtgggcatcatctttaagaac
ggggatgacctccggcaggacatgctgaccctgcagatgatccagctcatggacgtcctg
tggaagcaggaggggctggacctgaggatgaccccctatggctgcctccccaccggggac
cgcacaggcctcattgaggtggtactccgttcagacaccatcgccaacatccaactcaac
aagagcaacatggcagccacagccgccttcaacaaggatgccctgctcaactggctgaag
tccaagaacccgggggaggccctggatcgagccattgaggagttcaccctctcctgtgct
ggctattgtgtggccacatatgtgctgggcattggcgatcggcacagcgacaacatcatg
atccgagagagtgggcagctgttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgcgagcgtgtcccattcatcctcacctacgactttgtccat
gtgattcagcaggggaagactaataatagtgagaaatttgaacggttccggggctactgt
gaaagggcctacaccatcctgcggcgccacgggcttctcttcctccacctctttgccctg
atgcgggcggcaggcctgcctgagctcagctgctccaaagacatccagtatctcaaggac
tccctggcactggggaaaacagaggaggaggcactgaagcacttccgagtgaagtttaac
gaagccctccgtgagagctggaaaaccaaagtgaactggctggcccacaacgtgtccaaa
gacaacaggcagtag

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