KEGG   Homo sapiens (human): 5328
Entry
5328              CDS       T01001                                 
Symbol
PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA
Name
(RefSeq) urokinase-type plasminogen activator isoform 1 preproprotein
  KO
K01348  urokinase plasminogen activator [EC:3.4.21.73]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04610  Complement and coagulation cascades
hsa05202  Transcriptional misregulation in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05215  Prostate cancer
Network
nt06240  Transcription (cancer)
nt06272  Prostate cancer
nt06513  Complement cascade
nt06514  Coagulation cascade
  Element
N00128  TMPRSS2-ERG fusion to transcriptional activation
N00130  TMPRSS2-ETV5 fusion to transcriptional activation
N01518  Fibrinolytic system
N01520  Regulation of fibrinolytic system, C1INH
N01523  Regulation of fibrinolytic system, AAT
N01524  Regulation of fibrinolytic system, PAI
Disease
H01235  Bleeding disorder platelet-type
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    5328 (PLAU)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5328 (PLAU)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    5328 (PLAU)
   05206 MicroRNAs in cancer
    5328 (PLAU)
   05205 Proteoglycans in cancer
    5328 (PLAU)
  09162 Cancer: specific types
   05215 Prostate cancer
    5328 (PLAU)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5328 (PLAU)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    5328 (PLAU)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.73  u-plasminogen activator
     5328 (PLAU)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   5328 (PLAU)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   5328 (PLAU)
SSDB
Motif
Pfam: Trypsin Kringle DUF316 Kringle_2
Other DBs
NCBI-GeneID: 5328
NCBI-ProteinID: NP_001428083
OMIM: 191840
HGNC: 9052
UniProt: P00749
Structure
Position
10:73908832..73917494
AA seq 431 aa
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
NT seq 1296 nt   +upstreamnt  +downstreamnt
atgagagccctgctggcgcgcctgcttctctgcgtcctggtcgtgagcgactccaaaggc
agcaatgaacttcatcaagttccatcgaactgtgactgtctaaatggaggaacatgtgtg
tccaacaagtacttctccaacattcactggtgcaactgcccaaagaaattcggagggcag
cactgtgaaatagataagtcaaaaacctgctatgaggggaatggtcacttttaccgagga
aaggccagcactgacaccatgggccggccctgcctgccctggaactctgccactgtcctt
cagcaaacgtaccatgcccacagatctgatgctcttcagctgggcctggggaaacataat
tactgcaggaacccagacaaccggaggcgaccctggtgctatgtgcaggtgggcctaaag
ctgcttgtccaagagtgcatggtgcatgactgcgcagatggaaaaaagccctcctctcct
ccagaagaattaaaatttcagtgtggccaaaagactctgaggccccgctttaagattatt
gggggagaattcaccaccatcgagaaccagccctggtttgcggccatctacaggaggcac
cgggggggctctgtcacctacgtgtgtggaggcagcctcatcagcccttgctgggtgatc
agcgccacacactgcttcattgattacccaaagaaggaggactacatcgtctacctgggt
cgctcaaggcttaactccaacacgcaaggggagatgaagtttgaggtggaaaacctcatc
ctacacaaggactacagcgctgacacgcttgctcaccacaacgacattgccttgctgaag
atccgttccaaggagggcaggtgtgcgcagccatcccggactatacagaccatctgcctg
ccctcgatgtataacgatccccagtttggcacaagctgtgagatcactggctttggaaaa
gagaattctaccgactatctctatccggagcagctgaaaatgactgttgtgaagctgatt
tcccaccgggagtgtcagcagccccactactacggctctgaagtcaccaccaaaatgctg
tgtgctgctgacccacagtggaaaacagattcctgccagggagactcagggggacccctc
gtctgttccctccaaggccgcatgactttgactggaattgtgagctggggccgtggatgt
gccctgaaggacaagccaggcgtctacacgagagtctcacacttcttaccctggatccgc
agtcacaccaaggaagagaatggcctggccctctga

  All links  
Disease (3)   
   OMIM (3)   
Gene (37)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
   PROTHERM (5)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (59)   
   RefSeq(nuc) (13)   
   GenBank (23)   
   EMBL (23)   
3D Structure (156)   
   PDB (156)   
Protein domain (4)   
   Pfam (4)   
All databases (275)   

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