Entry |
|
Symbol |
PLCB3, SMDCD
|
Name |
(RefSeq) phospholipase C beta 3
|
KO |
|
Organism |
|
Pathway |
hsa04070 | Phosphatidylinositol signaling system |
hsa04072 | Phospholipase D signaling pathway |
hsa04261 | Adrenergic signaling in cardiomyocytes |
hsa04270 | Vascular smooth muscle contraction |
hsa04613 | Neutrophil extracellular trap formation |
hsa04621 | NOD-like receptor signaling pathway |
hsa04723 | Retrograde endocannabinoid signaling |
hsa04750 | Inflammatory mediator regulation of TRP channels |
hsa04919 | Thyroid hormone signaling pathway |
hsa04925 | Aldosterone synthesis and secretion |
hsa04927 | Cortisol synthesis and secretion |
hsa04928 | Parathyroid hormone synthesis, secretion and action |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
hsa04935 | Growth hormone synthesis, secretion and action |
hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
hsa04973 | Carbohydrate digestion and absorption |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05163 | Human cytomegalovirus infection |
|
Module |
hsa_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Network |
|
Element |
N00291 | CaSR-PTH signaling pathway |
N00301 | Angiotensin-aldosterone signaling pathway |
N00401 | CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway |
N00413 | CXCR4-GNB/G-PLCB-PKC signaling pathway |
N00428 | CCR5-GNB/G-PLCB/G-PKC signaling pathway |
N00546 | CXCL12-CXCR4-PKC-ERK signaling pathaway |
N00793 | TSH-DUOX2-TG signaling pathway |
N00869 | KISS1-KISS1R-PLCB-PKC signaling pathway |
N00873 | GnRH-GnRHR-PLCB-PKC signaling pathway |
N00882 | TAC3-TACR3-PLC-PKC signaling pathway |
N00918 | TRH-TRHR-PLCB-PKC signaling pathway |
N00953 | mGluR1-TRPC3 signaling pathway |
N00954 | Mutation-activated GRM1 to mGluR1-TRPC3 signaling pathway |
N00955 | Mutation-inactivated PRKCG to mGluR1-TRPC3 signaling pathway |
N00956 | Mutation-activated PRKCG to mGluR1-TRPC3 signaling pathway |
N00957 | Mutation-caused abberant ATXN2/3 to mGluR5-Ca2+ -apoptotic pathway |
N00958 | Mutation-activated ITPR1 to mGluR1-TRPC3 signaling pathway |
N00959 | ITPR1-reduced expression to mGluR1-TRPC3 signaling pathway |
N00960 | Mutation-caused aberrant SPTBN2 to mGluR1-TRPC3 signaling pathway |
N00984 | mGluR5-Ca2+ -apoptotic pathway |
N00985 | Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway |
N01000 | mAChR-Ca2+ -apoptotic pathway |
N01001 | Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway |
N01002 | Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway |
N01640 | GPCR-PLCB-ITPR signaling pathway |
N01765 | CXCR4-GNAQ-PLCB/G signaling pathway |
N01769 | CCR5-GNB/G-PLCB/G signaling pathway |
|
Disease |
H02185 | Spondylometaphyseal dysplasia |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
5331 (PLCB3)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
5331 (PLCB3)
04310 Wnt signaling pathway
5331 (PLCB3)
04070 Phosphatidylinositol signaling system
5331 (PLCB3)
04072 Phospholipase D signaling pathway
5331 (PLCB3)
04071 Sphingolipid signaling pathway
5331 (PLCB3)
04022 cGMP-PKG signaling pathway
5331 (PLCB3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5331 (PLCB3)
04613 Neutrophil extracellular trap formation
5331 (PLCB3)
04062 Chemokine signaling pathway
5331 (PLCB3)
09152 Endocrine system
04911 Insulin secretion
5331 (PLCB3)
04922 Glucagon signaling pathway
5331 (PLCB3)
04929 GnRH secretion
5331 (PLCB3)
04915 Estrogen signaling pathway
5331 (PLCB3)
04921 Oxytocin signaling pathway
5331 (PLCB3)
04926 Relaxin signaling pathway
5331 (PLCB3)
04935 Growth hormone synthesis, secretion and action
5331 (PLCB3)
04918 Thyroid hormone synthesis
5331 (PLCB3)
04919 Thyroid hormone signaling pathway
5331 (PLCB3)
04928 Parathyroid hormone synthesis, secretion and action
5331 (PLCB3)
04924 Renin secretion
5331 (PLCB3)
04925 Aldosterone synthesis and secretion
5331 (PLCB3)
04927 Cortisol synthesis and secretion
5331 (PLCB3)
09154 Digestive system
04970 Salivary secretion
5331 (PLCB3)
04971 Gastric acid secretion
5331 (PLCB3)
04972 Pancreatic secretion
5331 (PLCB3)
04973 Carbohydrate digestion and absorption
5331 (PLCB3)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
5331 (PLCB3)
09156 Nervous system
04724 Glutamatergic synapse
5331 (PLCB3)
04725 Cholinergic synapse
5331 (PLCB3)
04728 Dopaminergic synapse
5331 (PLCB3)
04726 Serotonergic synapse
5331 (PLCB3)
04720 Long-term potentiation
5331 (PLCB3)
04730 Long-term depression
5331 (PLCB3)
04723 Retrograde endocannabinoid signaling
5331 (PLCB3)
09157 Sensory system
04742 Taste transduction
5331 (PLCB3)
04750 Inflammatory mediator regulation of TRP channels
5331 (PLCB3)
09159 Environmental adaptation
04713 Circadian entrainment
5331 (PLCB3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5331 (PLCB3)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
5331 (PLCB3)
09171 Infectious disease: bacterial
05131 Shigellosis
5331 (PLCB3)
09174 Infectious disease: parasitic
05146 Amoebiasis
5331 (PLCB3)
05142 Chagas disease
5331 (PLCB3)
05143 African trypanosomiasis
5331 (PLCB3)
09164 Neurodegenerative disease
05010 Alzheimer disease
5331 (PLCB3)
05016 Huntington disease
5331 (PLCB3)
05017 Spinocerebellar ataxia
5331 (PLCB3)
05022 Pathways of neurodegeneration - multiple diseases
5331 (PLCB3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5331 (PLCB3)
05415 Diabetic cardiomyopathy
5331 (PLCB3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
5331 (PLCB3)
04934 Cushing syndrome
5331 (PLCB3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:hsa04131]
5331 (PLCB3)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
5331 (PLCB3)
Membrane trafficking [BR:hsa04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
5331 (PLCB3)
Endocytosis
Macropinocytosis
Phospholipase C
5331 (PLCB3)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
11:64251530..64269452
|
AA seq |
1234 aa
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS
AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD
EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL
GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH
KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG
DGPLVACASNGHAPGSSGHLSGADSESQEENTQL |
NT seq |
3705 nt +upstreamnt +downstreamnt
atggcgggcgcccagcccggcgtccacgcgctgcagttggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtgaccctgcgtgtggaccccaatggcttcttcttgtactggacgggccccaacatggag
gtggacacactggacatcagttccatcagggacacacggacaggccggtacgcccgcctg
cccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccggctggag
gagaagctgatgacggtggtgtctgggccagacccagtgaacacagtgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggtctgaggagctattcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgcaaagcatacacgaagctg
aagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtggagactgcgctggaatcctgtggcctcaaattcaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcggttcctgaacaagctg
tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaagccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgcgacccgagactcaac
gaagtgctgtacccgcccctgcggccctcccaggcccggctgctcatcgaaaagtatgag
cccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgctacctg
ggaggcgaggagaatggcatcctgcccctggaagccctggatctgagcacggacatgacc
cagccactgagtgcctacttcatcaactcctcgcataacacctatctcactgcggggcag
ctggctgggacctcgtcggtggagatgtaccgccaggcactactatggggctgccgctgc
gtggagctggacgtgtggaagggacggccgcctgaggaggaacccttcattacccacggc
ttcaccatgaccacagaggtgcctctgcgcgacgtgctggaggccattgccgagactgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccatgtggactcggcaaag
caacaggcaaagatggctgagtactgccgctccatctttggagacgcgctactcatcgag
cctctggacaagtacccgctggccccaggcgttcccctgcccagcccccaggacctgatg
ggccgtatcctggtgaagaacaagaagcggcaccgacccagcgcaggtggcccagacagc
gccgggcgcaagcggcccctggagcagagcaattctgccctgagcgagagctccgcggcc
accgagccctcctccccgcagctggggtctcccagctctgacagctgcccaggcctgagc
aatggggaggaggtagggcttgagaagcccagcctggagcctcagaagtctctgggtgac
gagggcctgaaccgaggcccctatgttcttggacctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaggaacagacagaccccaaaaagccaactacagatgagggcacagcc
agcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacatcgaacctgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcgtccttt
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcctccaactacatg
ccccagctcttctggaacgtagggtgccagcttgttgcgctcaacttccagaccctcgat
gtggcgatgcagctcaacgcgggcgtttttgagtacaacgggcgcagcgggtacctgctc
aagccggagttcatgcggcggccggacaagtccttcgaccccttcactgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcagggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgatacgcggcgc
aagtaccgcacccggacctctcaggggaactcgttcaaccccgtgtgggacgaagagccc
ttcgacttccccaaggtggtgctgcccacgctggcttcacttcgcattgcagcctttgag
gaggggggtaaattcgtagggcaccggatcctgcctgtctctgccatccgctccggatac
cactacgtctgcctgcggaacgaggccaaccaaccgctgtgcctgccggccctgctcatc
tacaccgaagcctcggactacattcctgacgaccaccaggactatgcggaggccctgatc
aaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgccctcatt
ggggagagtgaggctcaggctggccaagagacgtgccaggacacccagtctcagcagctg
gggtctcagccgtcctcaaaccccacccccagcccactggatgcctccccccgccggccc
cctggccccaccacctcccctgccagcacctccctcagcagcccagggcagcgtgatgat
ctcatcgccagcatcctctcagaggtggcccccaccccgctggatgagctccgaggtcac
aaggctctggtcaagctccggagccggcaagagcgagacctgcgggagctgcgcaagaag
catcagcggaaggcagtcaccctcacccgccgcctgctggatggcctggctcaggcacag
gctgagggcaggtgccggctgcggccaggtgccctaggtggggccgctgatgtggaggac
acgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcag
agcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctggaacac
ctgagacaggctctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttc
aagaggctgaaagagatgaacgagagggagaagaaggagctgcagaagatcctggacaga
aagcgccataacagcatctcggaggccaagatgagggacaagcataagaaggaggcggaa
ctgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag
gaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacag
ctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgg
gcgaggctcccccaggagatccgccggagcctgctgggcgagatgccggaggggctgggg
gacgggcctctggtggcctgtgccagcaacggtcacgcacccgggagcagcgggcacctg
tcgggcgctgactcggagagccaggaggagaacacgcagctctga |