KEGG   Homo sapiens (human): 5340
Entry
5340              CDS       T01001                                 
Symbol
PLG, HAE4
Name
(RefSeq) plasminogen
  KO
K01315  plasminogen [EC:3.4.21.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
hsa05164  Influenza A
Network
nt06507  TGFB signaling
nt06514  Coagulation cascade
  Element
N01460  Plasmin mediated activation of latent TGF-beta
N01518  Fibrinolytic system
Disease
H01006  Hereditary angioedema
H01206  Plasminogen deficiency
Drug target
Aminocaproic acid: D00160<US>
Aminomethylbenzoic acid: D07568
Plasminogen: D12149
Tranexamic acid: D01136<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5340 (PLG)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5340 (PLG)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    5340 (PLG)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    5340 (PLG)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5340 (PLG)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5340 (PLG)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.7  plasmin
     5340 (PLG)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   5340 (PLG)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   5340 (PLG)
SSDB
Motif
Pfam: Kringle Trypsin PAN_1 DUF1986 Trypsin_2 DUF3719
Other DBs
NCBI-GeneID: 5340
NCBI-ProteinID: NP_000292
OMIM: 173350
HGNC: 9071
Ensembl: ENSG00000122194
CPD: C00471
UniProt: P00747
Structure
Position
6:160702193..160754097
AA seq 810 aa
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT
CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN
GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE
CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE
LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS
AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE
QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG
LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED
CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG
PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT
RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE
PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ
LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW
GLGCARPNKPGVYVRVSRFVTWIEGVMRNN
NT seq 2433 nt   +upstreamnt  +downstreamnt
atggaacataaggaagtggttcttctacttcttttatttctgaaatcaggtcaaggagag
cctctggatgactatgtgaatacccagggggcttcactgttcagtgtcactaagaagcag
ctgggagcaggaagtatagaagaatgtgcagcaaaatgtgaggaggacgaagaattcacc
tgcagggcattccaatatcacagtaaagagcaacaatgtgtgataatggctgaaaacagg
aagtcctccataatcattaggatgagagatgtagttttatttgaaaagaaagtgtatctc
tcagagtgcaagactgggaatggaaagaactacagagggacgatgtccaaaacaaaaaat
ggcatcacctgtcaaaaatggagttccacttctccccacagacctagattctcacctgct
acacacccctcagagggactggaggagaactactgcaggaatccagacaacgatccgcag
gggccctggtgctatactactgatccagaaaagagatatgactactgcgacattcttgag
tgtgaagaggaatgtatgcattgcagtggagaaaactatgacggcaaaatttccaagacc
atgtctggactggaatgccaggcctgggactctcagagcccacacgctcatggatacatt
ccttccaaatttccaaacaagaacctgaagaagaattactgtcgtaaccccgatagggag
ctgcggccttggtgtttcaccaccgaccccaacaagcgctgggaactttgtgacatcccc
cgctgcacaacacctccaccatcttctggtcccacctaccagtgtctgaagggaacaggt
gaaaactatcgcgggaatgtggctgttaccgtgtccgggcacacctgtcagcactggagt
gcacagacccctcacacacataacaggacaccagaaaacttcccctgcaaaaatttggat
gaaaactactgccgcaatcctgacggaaaaagggccccatggtgccatacaaccaacagc
caagtgcggtgggagtactgtaagataccgtcctgtgactcctccccagtatccacggaa
caattggctcccacagcaccacctgagctaacccctgtggtccaggactgctaccatggt
gatggacagagctaccgaggcacatcctccaccaccaccacaggaaagaagtgtcagtct
tggtcatctatgacaccacaccggcaccagaagaccccagaaaactacccaaatgctggc
ctgacaatgaactactgcaggaatccagatgccgataaaggcccctggtgttttaccaca
gaccccagcgtcaggtgggagtactgcaacctgaaaaaatgctcaggaacagaagcgagt
gttgtagcacctccgcctgttgtcctgcttccagatgtagagactccttccgaagaagac
tgtatgtttgggaatgggaaaggataccgaggcaagagggcgaccactgttactgggacg
ccatgccaggactgggctgcccaggagccccatagacacagcattttcactccagagaca
aatccacgggcgggtctggaaaaaaattactgccgtaaccctgatggtgatgtaggtggt
ccctggtgctacacgacaaatccaagaaaactttacgactactgtgatgtccctcagtgt
gcggccccttcatttgattgtgggaagcctcaagtggagccgaagaaatgtcctggaagg
gttgtaggggggtgtgtggcccacccacattcctggccctggcaagtcagtcttagaaca
aggtttggaatgcacttctgtggaggcaccttgatatccccagagtgggtgttgactgct
gcccactgcttggagaagtccccaaggccttcatcctacaaggtcatcctgggtgcacac
caagaagtgaatctcgaaccgcatgttcaggaaatagaagtgtctaggctgttcttggag
cccacacgaaaagatattgccttgctaaagctaagcagtcctgccgtcatcactgacaaa
gtaatcccagcttgtctgccatccccaaattatgtggtcgctgaccggaccgaatgtttc
atcactggctggggagaaacccaaggtacttttggagctggccttctcaaggaagcccag
ctccctgtgattgagaataaagtgtgcaatcgctatgagtttctgaatggaagagtccaa
tccaccgaactctgtgctgggcatttggccggaggcactgacagttgccagggtgacagt
ggaggtcctctggtttgcttcgagaaggacaaatacattttacaaggagtcacttcttgg
ggtcttggctgtgcacgccccaataagcctggtgtctatgttcgtgtttcaaggtttgtt
acttggattgagggagtgatgagaaataattaa

  All links  
Disease (3)   
   OMIM (3)   
Gene (74)   
   RefGene (67)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PROTHERM (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
3D Structure (49)   
   PDB (49)   
Protein domain (6)   
   Pfam (6)   
All databases (158)   

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