KEGG   Homo sapiens (human): 5422
Entry
5422              CDS       T01001                                 

Symbol
POLA1, NSX, POLA, VEODS, p180
Name
(RefSeq) DNA polymerase alpha 1, catalytic subunit
  KO
K02320  DNA polymerase alpha subunit A [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Disease
H00658  Syndromic X-linked mental retardation
H02484  X-linked reticulate pigmentary disorder with systemic manifestations
Drug target
Clofarabine: D03546<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5422 (POLA1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5422 (POLA1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5422 (POLA1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase alpha / primase complex
    5422 (POLA1)
SSDB
Motif
Pfam: DNA_pol_B DNA_pol_B_exo1 zf-DNA_Pol DNA_pol_alpha_N DNA_pol_B_2 DUF1744 rRNA_proc-arch
Other DBs
NCBI-GeneID: 5422
NCBI-ProteinID: NP_058633
OMIM: 312040
HGNC: 9173
Ensembl: ENSG00000101868
Vega: OTTHUMG00000021277
Pharos: P09884(Tclin)
UniProt: P09884
Structure
PDB: 

Position
Xp22.11-p21.3
AA seq 1462 aa
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
LSRSGYSEVNLSKLFAGCAVKS
NT seq 4389 nt   +upstreamnt  +downstreamnt
atggcacctgtgcacggcgacgactctctgtcagattcagggagttttgtatcttctcga
gcccggcgagaaaaaaaatcaaagaaggggcgccaagaagccctagaaagactgaaaaag
gctaaagctggtgagaagtataaatatgaagtcgaggacttcacaggtgtttatgaagaa
gttgatgaagaacagtattcgaagctggttcaggcacgccaggatgatgactggattgtg
gatgatgatggtattggctatgtggaagatggccgagagatttttgatgatgaccttgaa
gatgatgcccttgatgctgatgagaaaggaaaagatggtaaagcacgcaataaagacaag
aggaatgtaaagaagctcgcagtgacaaaaccgaacaacattaagtcaatgttcattgct
tgtgctggaaagaaaactgcagataaagctgtagacttgtccaaggatggtctgctaggt
gacattctacaggatcttaacactgagacacctcaaataactccaccacctgtaatgata
ctgaagaagaaaagatccattggagcttcaccgaatcctttctctgtgcacaccgccacg
gcagttccttcaggaaaaattgcttcccctgtctccagaaaggagcctccattaactcct
gttcctcttaaacgtgctgaatttgctggcgatgatgtacaggtcgagagtacagaagaa
gagcaggagtcaggggcaatggagtttgaagatggtgactttgatgagcccatggaagtt
gaagaggtggacctggagcctatggctgccaaggcttgggacaaagagagtgagccagca
gaggaagtgaaacaagaggcggattctgggaaagggaccgtgtcctacttaggaagtttt
ctcccggatgtctcttgttgggacattgatcaagaaggtgatagcagtttctcagtgcaa
gaagttcaagtggattccagtcacctcccattggtaaaaggggcagatgaggaacaagta
ttccacttttattggttggatgcttatgaggatcagtacaaccaaccaggtgtggtattt
ctgtttgggaaagtttggattgaatcagccgagacccatgtgagctgttgtgtcatggtg
aaaaatatcgagcgaacgctttacttccttccccgtgaaatgaaaattgatctaaatacg
gggaaagaaacaggaactccaatttcaatgaaggatgtttatgaggaatttgatgagaaa
atagcaacaaaatataaaattatgaagttcaagtctaagccagtggaaaagaactatgct
tttgagatacctgatgttccagaaaaatctgagtacttggaagttaaatactcggctgaa
atgccacagcttcctcaagatttgaaaggagaaactttttctcatgtatttgggaccaac
acatctagcctggaactgttcttgatgaacagaaagatcaaaggaccttgttggcttgaa
gtaaaaagtccacagctcttgaatcagccagtcagttggtgtaaagttgaggcaatggct
ttgaaaccagacctggtgaatgtaattaaggatgtcagtccaccaccgcttgtcgtgatg
gctttcagcatgaagacaatgcagaatgcaaagaaccatcaaaatgagattattgctatg
gcagctttggtccatcacagttttgcattggataaagcagccccaaagcctccctttcag
tcacacttctgtgttgtgtctaaaccaaaggactgtatttttccatatgctttcaaagaa
gtcattgagaaaaagaatgtgaaggttgaggttgctgcaacagaaagaacactgctaggt
tttttccttgcaaaagttcacaaaattgatcctgatatcattgtgggtcataatatttat
gggtttgaactggaagtactactgcagagaattaatgtgtgcaaagctcctcactggtcc
aagataggtcgactgaagcgatccaacatgccaaagcttgggggccggagtggatttggt
gaaagaaatgctacctgtggtcgaatgatctgtgatgtggaaatttcagcaaaggaattg
attcgttgtaaaagctaccatctgtctgaacttgttcagcagattctaaaaactgaaagg
gttgtaatcccaatggaaaatatacaaaatatgtacagtgaatcttctcaactgttatac
ctgttggaacacacctggaaagatgccaagttcattttgcagatcatgtgtgagctaaat
gttcttccattagcattgcagatcactaacatcgctgggaacattatgtccaggacgctg
atgggtggacgatccgagcgtaacgagttcttgttgcttcatgcattttacgaaaacaac
tatattgtgcctgacaagcagattttcagaaagcctcagcaaaaactgggagatgaagat
gaagaaattgatggagataccaataaatacaagaaaggacgtaagaaagcagcttatgct
ggaggcttggttttggaccccaaagttggtttttatgataagttcattttgcttctggac
ttcaacagtctatatccttccatcattcaggaatttaacatttgttttacaacagtacaa
agagttgcttcagaggcacagaaagttacagaggatggagaacaagaacagatccctgag
ttgccagatccaagcttagaaatgggcattttgcccagagagatccggaaactggtagaa
cggagaaaacaagtcaaacagctaatgaaacagcaagacttaaatccagaccttattctt
cagtatgacattcgacagaaggctttgaagctcacagcgaacagtatgtatggttgcctg
ggattttcctatagcagattttacgccaaaccactggctgccttggtgacatacaaagga
agggagattttgatgcatacgaaagagatggtacaaaagatgaatcttgaagttatttat
ggagatacagattcaattatgataaacaccaatagcaccaatctggaagaagtatttaag
ttgggaaacaaggtaaaaagtgaagtgaataagttgtacaaactgcttgaaatagacatt
gatggggttttcaagtctctgctactgctgaaaaaaaagaagtacgctgctctggttgtt
gagccaacgtcggatgggaattatgtcaccaaacaggagctcaaaggattagatatagtt
agaagagattggtgtgatcttgctaaagacactggaaactttgtgattggccagattctt
tctgatcaaagccgggacactatagtggaaaacattcagaagaggctgatagaaattgga
gaaaatgtgctaaatggcagtgtcccagtgagccagtttgaaattaacaaggcattgaca
aaggatccccaggattaccctgataaaaaaagcctacctcatgtacatgttgccctctgg
ataaattctcaaggaggcagaaaggtgaaagctggagatactgtgtcatatgtcatctgt
caggatggatcaaacctcactgcaagtcagagggcctatgcgcctgagcagctgcagaaa
caggataatctaaccattgacacccagtactacctggcccagcagatccacccagtcgtg
gctcggatctgtgaaccaatagacggaattgatgctgtcctcattgcaacgtggttggga
cttgaccccacccaatttagagttcatcattatcataaagatgaagagaatgatgctcta
cttggtggcccagcacagctcactgatgaagagaaatacagggactgtgaaagattcaaa
tgtccatgccctacatgtggaactgagaatatttatgataatgtctttgatggttcggga
acagatatggagcccagcttgtatcgttgcagtaacatcgattgtaaggcttcacctctg
acctttacagtacaactgagcaacaaattgatcatggacattagacgtttcattaaaaag
tactatgatggctggttgatatgtgaagagccaacctgtcgcaatcgaactcgtcacctt
ccccttcaattctcccgaactgggcctctttgcccagcctgcatgaaagctacacttcaa
ccagagtattctgacaagtccctgtacacccagctgtgcttttaccggtacatttttgat
gcggagtgtgcactggagaaacttactaccgatcatgagaaagataaattgaagaagcaa
ttttttacccccaaagttctgcaggactacagaaaactcaagaacacagcagagcaattc
ttgtcccgaagtggctactccgaagtgaatctgagcaaactcttcgctggttgtgccgtg
aaatcctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (24)   
   RefSeq(nuc) (12)   
   GenBank (6)   
   EMBL (6)   
Protein domain (7)   
   Pfam (7)   
All databases (71)   

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