KEGG   Homo sapiens (human): 5423
Entry
5423              CDS       T01001                                 

Gene name
POLB
Definition
(RefSeq) DNA polymerase beta
  KO
K02330  DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06140  Transcription (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
  Element
N00511  HTLV-1 Tax to E47-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    5423 (POLB)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    5423 (POLB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5423 (POLB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5423 (POLB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5423 (POLB)
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.99  Other carbon-oxygen lyases
    4.2.99.-  
     5423 (POLB)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Short Patch-BER factors
     5423 (POLB)
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    X-family DNA polymerases
     5423 (POLB)
SSDB
Motif
Pfam: DNA_pol_B_palm DNA_pol_lambd_f HHH_8 DNA_pol_B_thumb HHH_5 HHH Cdd1 HHH_2 NTP_transf_2
Other DBs
NCBI-GeneID: 5423
NCBI-ProteinID: NP_002681
OMIM: 174760
HGNC: 9174
Ensembl: ENSG00000070501
Vega: OTTHUMG00000164093
Pharos: P06746(Tchem)
UniProt: P06746
Structure
PDB: 
5WO0 4KLI 2FMP 5VS3 4KLG 6BTF 4KLM 5U2T 6CR4 5V1G 5V1O 5U2R 4TUP 4KLJ 4F5N 4KLL 6CTR 5U9H 5TBC 4R63 4KLF 4KLO 4F5P 3OGU 6CTQ 5VS4 6BEM 4UAZ 4KLH 6MR8 6CTU 6BEL 5VRY 5UGO 4RPX 4RPY 4UBB 4UAW 3JPQ 6CTN 4RT2 4RT3 4KLD 3RH4 6CPQ 6CR3 5V1H 4R65 4UB4 4GXI 4DOC 6E3V 6CR9 5UGP 6DIA 5DBA 4KLE 4KLU 6CTW 6CR5 5BOL 4UAY 4KLS 4KLT 6DIC 5V1P 4P2H 6CTI 6CTL 6CTT 5UGN 5TZV 5TB8 5J0O 5J0Q 5J0R 5J0S 5J0T 5J0X 5J0Y 5BPC 5BOM 4RQ3 4RQ7 4RQ8 4UBC 4LVS 4KLQ 4JWM 4GXK 4F5O 3TFR 3TFS 3RJG 3RJJ 3MBY 3JPO 3JPS 3ISB 3ISC 2FMS 1TV9 5V1N 4M9G 6E3W 6CTV 6CTX 6CU9 6CTO 5VEZ 5V1I 4M9J 6CUB 6CR8 5VRZ 4DO9 4DOA 4DOB 3RH6 4UB3 4O5K 5V1R 4PGX 4PPX 5EOZ 4M9L 6N2R 6CTJ 6CTM 6CR6 5WNY 5VS0 5J2C 5J2D 5J2E 5J2F 5J2G 5J2K 5J0U 4RQ4 3RJE 3RJK 3RH5 3JPP 3JPR 2PXI 2ISO 2I9G 1ZJM 4MFC 6MR7 6CTK 6G2Q 6CRB 4YMO 4UB5 4PHE 3JPN 3JPT 3C2M 5U8H 6CUA 5U8G 4TUR 5V1F 6CLY 4RPZ 6CTP 6BTE 5WNZ 5VRX 5J29 5J2J 5J0P 4YMM 4RQ0 4RQ2 4R64 4GXJ 4F5R 3RJH 3GDX 2ISP 2FMQ 1BPY 5DB7 4PHD 4YN4 5DBB 4RQ6 4R66 4NY8 4F5Q 6E3R 4PGY 4NLN 4MFA 4M9N 4M2Y 6CR7 4O9M 6CRC 5U2S 5J2H 4PGQ 3RJF 3RJI 4RQ5 4MF8 6CRH 5VS2 4UB1 5HHH 4O5C 4TUQ 4M47 5TBB 4M9H 4JWN 5J2I 5J0W 5DBC 4MF2 3C2K 1BPX 4TUS 4NM1 4Z6F 5U8I 5DB9 6N2S 5TB9 5TBA 4NLK 5VS1 5J2A 5J2B 3LK9 2P66 4Z6D 4UB2 5HHI 4PHA 4NM2 4O5E 5WNX 5DB8 4PH5 4MFF 4NXZ 5VRW 4YMN 6N2T 4PHP 3ISD 3C2L 1TVA 1BPZ 9ICX 9ICW 1ZJN 5V1J 6E3X 4Z6C 4NLZ 4RQ1 8ICK 1ZQI 9ICK 9ICV 8ICO 4Z6E 1MQ3 7ICV 7ICE 7ICI 7ICN 7ICS 7ICT 8ICC 8ICI 1ZQP 9ICL 8ICN 5DB6 7ICH 7ICK 7ICQ 8ICF 1ZQF 8ICM 8ICR 9ICQ 9ICM 9ICO 9ICS 9ICU 8ICP 8ICS 9ICH 9ICY 7ICG 7ICM 7ICP 7ICR 1ZQN 8ICQ 9ICR 9ICN 9ICT 8ICA 8ICU 8ICX 9ICA 9ICF 9ICG 1MQ2 7ICF 7ICL 8ICB 1ZQG 1ZQH 8ICZ 9ICP 8ICL 8ICT 8ICY 9ICC 9ICI 9ICJ 8ICE 8ICJ 1ZQA 1ZQB 1ZQC 1ZQK 1ZQM 1ZQO 8ICV 9ICB 7ICO 7ICU 8ICG 8ICH 1ZQJ 1ZQL 1ZQQ 1ZQS 8ICW 9ICE 1ZQT 7ICJ 1ZQD 1ZQE 1ZQR

Position
8p11.21
AA seq 335 aa
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
NT seq 1008 nt   +upstreamnt  +downstreamnt
atgagcaaacggaaggcgccgcaggagactctcaacgggggaatcaccgacatgctcaca
gaactcgcaaactttgagaagaacgtgagccaagctatccacaagtacaatgcttacaga
aaagcagcatctgttatagcaaaatacccacacaaaataaagagtggagctgaagctaag
aaattgcctggagtaggaacaaaaattgctgaaaagattgatgagtttttagcaactgga
aaattacgtaaactggaaaagattcggcaggatgatacgagttcatccatcaatttcctg
actcgagttagtggcattggtccatctgctgcaaggaagtttgtagatgaaggaattaaa
acactagaagatctcagaaaaaatgaagataaattgaaccatcatcagcgaattgggctg
aaatattttggggactttgaaaaaagaattcctcgtgaagagatgttacaaatgcaagat
attgtactaaatgaagttaaaaaagtggattctgaatacattgctacagtctgtggcagt
ttcagaagaggtgcagagtccagtggtgacatggatgttctcctgacccatcccagcttc
acttcagaatcaaccaaacagccaaaactgttacatcaggttgtggagcagttacaaaag
gttcattttatcacagataccctgtcaaagggtgagacaaagttcatgggtgtttgccag
cttcccagtaaaaatgatgaaaaagaatatccacacagaagaattgatatcaggttgata
cccaaagatcagtattactgtggtgttctctatttcactgggagtgatattttcaataag
aatatgagggctcatgccctagaaaagggtttcacaatcaatgagtacaccatccgtccc
ttgggagtcactggagttgcaggagaacccctgccagtggatagtgaaaaagacatcttt
gattacatccagtggaaataccgggaacccaaggaccggagcgaatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   PRONIT (19)   
   VEGA (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (42)   
   RefSeq(nuc) (12)   
   GenBank (15)   
   EMBL (15)   
Protein domain (9)   
   Pfam (9)   
All databases (107)   

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